OptiMelt Automated Melting Point System - Stanford Research ...

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10 Getting Started Chapter 18. Preheat the oven to the Start TemperatureTouch the Heat button on the Melt screen to rapidly preheat the oven to the StartTemperature.An audible tone is heard and the Ready LED is turned on as soon as the Start temperatureis reached and becomes stable.OptiMelt is now ready for a melting point determination.9. Insert the sample capillariesInsert the capillary sample tube(s) into the oven and wait a few seconds for thetemperature of the oven to stabilize (thermal soak).Tips• Never force a capillary into the heating block! Once the capillary is inserted into asample hole, it should literally drop down to the bottom of the heating stand.• Introducing the capillaries at this time minimizes sample exposure to hightemperatures. This is a very important consideration for labile samples which meltwith decomposition.10. Initiate Heating RampTouch the Start Button on the Melt Screen to initiate the temperature ramp and theautomated melt determination process. After a brief delay the oven temperature willcommence to rise at the specified ramp Rate. The capillary tubes must not be disturbedwhile the ramping takes place. The heating ramp is terminated when (1) the Stoptemperature is reached or (2) when the Halt button is touched.Touch the Graph button at any time to view the evolution of the Melt Graph generated bythe Digital Image Processor during the ramping process.Touch the Halt button at any time to terminate the heating process before the Stoptemperature is reached.TipUse the Halt button if the sample(s) is observed to completely melt before the Stoptemperature is reached. The actual Halt temperature is recorded in the test report.11. View the MeltVisualization of the melt during the heating ramp is via the observation window locatedon the front panel of OptiMelt. All three capillaries can be observed simultaneously.All important changes that take place in the capillary tubes can be manually flagged bytouching the individual “sample buttons” located at the bottom of the Melt screen. Thethree samples are identified as Left, Center and Right according to their physical locationin the heating block.OptiMelt Automated Melting Point System
Chapter 1 Getting Started 11Figure 9. Use the Sample Buttons to flag important changes in the samples during the analysis.At the end of the analysis, all manual and automated results are saved in a report and theheater stand is automatically cooled back down to the Start temperature in preparation forthe next determination. A hard copy of the Report is also printed out if an optional printeris connected and OptiMelt is configured for automated print out of results (See “PrinterConfiguration” section later in this manual).A distinct audible alarm and a blinking Ready LED prompt the availability of a newReport.Important!Samples cannot be remelted! All melted capillaries MUST BE DISCARDED at the endof the analysis.12. Recall the informationTouch the Report button to display a summary Report for the melting point determinationperformed. The Newest Report is displayed on the screen.Compare the results to the known melting point(s) of the substance(s) analyzed.Figure 10. Melt Report screen.TipOptiMelt stores the last eight Melt Point Reports in memory. Touch the Select button tochoose a Report to display.OptiMelt Automated Melting Point System
Page 4 and 5: iiSafety and Preparation For Use•
Page 6 and 7: ivSafety and Preparation For UseOpt
Page 8 and 9: viContentsMelting Point Range 57Mel
Page 10 and 11: viiiFront Panel OverviewReady LEDA
Page 12 and 13: xBack Panel OverviewPrinterOptiMelt
Page 14 and 15: xiiSpecificationsOptiMelt Automated
Page 16 and 17: 2 Getting Started Chapter 1• Repl
Page 18 and 19: 4 Getting Started Chapter 1Ceramic
Page 20 and 21: 6 Getting Started Chapter 1Principl
Page 22 and 23: 8 Getting Started Chapter 1Quick St
Page 26 and 27: 12 Getting Started Chapter 1Touch t
Page 28 and 29: 14 Getting Started Chapter 1If none
Page 30 and 31: 16 Getting Started Chapter 1• Tou
Page 32 and 33: 18 Getting Started Chapter 1OptiMel
Page 34 and 35: 20 Displays and Menus Chapter 2Nume
Page 36: 22 Melt Screen Chapter 2Melt Screen
Page 39 and 40: Chapter 2 Melt Screen 25Touch the T
Page 41 and 42: Chapter 2 Melt Screen 27Select Newe
Page 43 and 44: Chapter 2 Melt Screen 29Select Came
Page 45 and 46: Chapter 2 Melt Screen 31Options Men
Page 47 and 48: Chapter 2 Melt Screen 33The thermod
Page 49 and 50: Chapter 2 Timer Screen 35ResetTouch
Page 51 and 52: Chapter 2 T Meter Screen 37Alarm Lo
Page 53 and 54: Chapter 2 System Screen 39System Sc
Page 55 and 56: Chapter 2 System Screen 41The Print
Page 57 and 58: Chapter 2 System Screen 43Screen Me
Page 59 and 60: Melting Point Determination 45Chapt
Page 61 and 62: Chapter 3 Melting Point Determinati
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Chapter 3 Melting Point Determinati
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Maintenance and Calibration 63Chapt
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Chapter 4 Maintenance and Calibrati
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Pharmacopeia vs. Thermodynamic Melt
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Appendix A Pharmacopeia vs. Thermod
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Melting Point Certified Reference S
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Appendix B Melting Point Certified
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Appendix B Melting Point Certified
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Using Melt Graphs 91Appendix CUsing
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Appendix C Using Melt Graphs 93The
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OptiMelt Remote Programming 95Appen
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Appendix D OptiMelt Remote Programm
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