CURRICULUM VITAE ADRIAN S. WOOLF - Oxford Journals

CURRICULUM VITAE
ADRIAN S. WOOLF
Biomedical Research Centre Professor of Paediatric Science,
Updated 17 August 2011
Developmental Biomedicine Research Group,
School of Biomedicine,
University of Manchester, UK

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1. SELF ASSESSMENT - PERSONAL STATEMENT
Overview – Main Achievements
● In 2010 I took up a new Chair, Biomedical Research Centre Professor of Paediatric Science
(http://www.medicine.manchester.ac.uk/staff/AdrianWoolf) in the Developmental Biomedicine
Research Group, within the School of Biomedicine in the Faculty of Medical and Human Sciences
at the University of Manchester.
● In 1998 I established an academic Unit for Nephrology and Urology at the UCL Institute of
Child Health, London, UK, which I headed until the end of 2009.
● My research and development work unites Nephrology, Urology, Genetics, Fetal Medicine and
Histopathology clinical services with perspectives from Developmental and Cell Biology and
Molecular Genetics science.
● I have published over 100 original research publications, and over 60 review articles/chapters,
with the main focus on normal and abnormal kidney and urinary tract development.
● According Harzing‟s Publish or Perish web-tool, my „h index‟ is 38, with nine of my publications
having been cited at least 100 times, and 29 others having been cited at least 38 times.
● I have supervised clinical and science students leading to eleven PhD, three MD and two MSc
awarded theses.
● I have been awarded over £4 million through peer-reviewed grants, a figure which excludes
numerous Fellowship awarded to my students.
● From 2006-2009 a clinic at Great Ormond Street Hospital, focusing on kidney and urinary tract
malformations, which has an impact on clinical management and genetic counseling.
● I was a Trustee and Honorary Secretary of The Renal Association (2000-2004)
● I was the Research Secretary of the British Association for Paediatric Nephrology (2000-2002).
● I served on the National Kidney Research Fund (now called Kidney Research UK) grants
committee (1997-2002).
Service delivery
● I have undertaken a Paediatric Nephrology clinic at Great Ormond Street Hospital (1997present),
initially following-up children seen by Professor Martin Barratt.
● In 2006, I established a clinic with Raoul Henenkam, Professor of Clinical Genetics, to make
genetic diagnoses in families with congenital kidney and urinary tract malformations. As of May
2009, we had assessed 86 index cases from 62 families at this special NHS clinic.
Service development
● I established (1997) and chaired a forum for senior academic and clinical Nephrology and
Urology staff to bring together academic and clinical issues.
● I performed two UK-wide surveys (2000) on behalf of the British Society for Paediatric
Nephrology, targeting trainees and Consultants, to establish a „state-of-the-nation‟ picture of
academic training in UK Paediatric Nephrology.
● I took on a newly-formed role (2000-2002), that of academic advisor in annual College
Speciality Advisory Committee assessments of all UK Paediatric Nephrology SpRs.
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1. SELF ASSESSMENT - PERSONAL STATEMENT (continued)
Management
● In 2010 I took up a new Chair, Professor of Paediatric Science at the University of Manchester,
UK, (http://www.medicine.manchester.ac.uk/staff/AdrianWoolf) with a remit to establish a new
research group.
● In 1998 I established an academic Unit for Nephrology and Urology at the UCL Institute of
Child Health, London, UK, which I headed until the end of 2009.
● I forged interactive links between Nephrology, Urology, Clinical Genetics, Fetal Medicine and
Histopathology clinical services, with Developmental Biology and Molecular Genetics science
laboratories.
● My management strategy established an internationally-competitive academic centre for clinical
and laboratory science. Creating an active research and development milieu has positive
implications for clinical services, especially for Paediatric Nephrology and Urology.
● I was Honorary Secretary (2000-2004) to the Renal Association, the main society for all UK
Nephrologists and scientists interested in kidney disease. I was also a Renal Association
Trustee/Director. In these roles, I managed thrice-yearly Executive Committee and Trustee
meetings, twice-yearly Clinical Conferences, the Annual General Meeting and made reports to
Companies House and the Charity Commission.
● I was Research Secretary of the British Association for Paediatric Nephrology (2000-2003),
organising the Annual Research Conference with the Royal College of Paediatrics and Child
Health, also serving at that time on the Executive Committee and acting as Academic Advisor at
College Speciality Advisory Committee assessments for Paediatric Nephrology Specialist
Registrars.
● I was member of National Kidney Research Fund Research Grants Committee (1997-2002).
● From 2002-2007 I was Editor of a new journal, Nephron Experimental Nephrology, and I have
served on the Editorial Boards of Kidney International (2001-2010) and the Journal of the
American Society of Nephrology (2001-2005), the two highest impact factor Nephrology journals.
Teaching
● I spend a considerable amount of time nurturing academic careers of junior clinicians and
scientists, and have supervised 11 PhD, 3 MD and 2 MSc completed theses, several performed
by Paediatric Nephrologists and Urologists.
● Three of my junior staff became Lecturers at University College London, and one of these is
now Reader and was also Head of Learning and Teaching at UCL Institute of Child Health.
Another of my previous students returned to work with me, having been awarded a five year
Senior Fellowship from Kidney Research UK.
● I was Director of the UCL ICH‟s annual Continuing Education in Paediatric Nephrology Week
(1997-2010)
● I chaired Wednesday Lunchtime Clinical Presentations at Great Ormond Street Hospital (2001-
2009), a teaching forum for clinicians and nurses.
● I helped to initiate, and chaired up to 2009, Nephrology „Bipartite‟ meetings which provide a
forum for exchange of clinical cases and research from Great Ormond Street Hospital, and local
Adult Nephrology centres including University College and Royal Free Hospitals.
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1. SELF ASSESSMENT - PERSONAL STATEMENT (continued)
Research
Overview
● My overall aim is to unravel the pathogenesis of kidney and urinary tract malformations, the
commonest causes of childhood end-stage renal failure.
● I have published over 100 original research publications, most on normal and abnormal kidney
and urinary tract development.
● According Harzing‟s Publish or Perish web-tool, my „h index‟ is 38, with nine of my publications
having been cited at least 100 times, and 29 others having been cited at least 38 times.
● I co-edited a book (2003): The Kidney - from Normal Developmental to Congenital Disease.
● I have been awarded over £4 million through peer-reviewed grants, a figure excluding the
numerous Fellowship grants awarded to my students. Major collaborative grants have included
those from the Wellcome Trust and Medical Research Council to establish and analyse a UK
DNA Bank on from families with vesico-ureteric reflux and reflux nephropathy.
Basic mechanisms of renal differentiation.
● I implicated hepatocyte growth factor and glial cell line-derived neurotrophic factor in ureteric
bud morphogenesis.
● I provided evidence for an endogenous origin of renal capillaries.
● I demonstrated that angiopoietins modulate renal capillary morphogenesis.
● I reported that Teashirt-3, a newly-recognised transcription factor, is needed for smooth muscle
differentiation and peristalsis in the ureter.
Animal models of renal disease.
● I am defining the biology of human nephrogenesis genes in animal models, both in vitro (e.g.
organ and cells culture) and in vivo (genetically-engineered mice and in zebrafish).
● I reported that glial cell line-derived neurotrophic factor rescues renal agenesis in a genetic
animal model of human disease.
● I found deregulated expression of angiopoietins in acute tubular necrosis and
glomerulonephritis, and am exploring potential therapeutic effects of these growth factors.
● I demonstrated that renal cyst formation is inhibited by a microtubule-stabilising drug, Taxol,
and that a cell adhesion molecule, galectin-3, modulates cyst growth.
● I demonstrated that urinary flow impairment deregulates gene expression and cell turnover in
fetal kidneys, providing a model for human kidney dysplasia. I also studied a model of posterior
urethral valves to define aberrations of fetal bladder physiology and cell biology.
● I discovered that maternal low protein diet causes apoptotic deletion of nephron precursor cells
accompanied by altered gene expression at the start of kidney development.
Human renal malformations.
● I described imbalanced cell turnover in human dysplastic kidneys, prime examples of disturbed
epithelial/mesenchymal interaction, correlating this with aberrant gene expression of
● I studied human renal dysplastic cells in culture, showing that TGF�1 downregulates
proliferation and induces a pathological epithelial to mesenchymal transformation.
● I published a randomized, prospective trial comparing renal function in medical and surgical
treatment of vesicoureteric reflux, and also a meta-analysis to determine the value of finding
reflux as a predictor of renal damage in children with urine infection.
● In various collaborations, I facilitated discovery of mutations, and/or explored the expression
and roles of genes, in the Kallmann, Bardet-Biedl, renal cysts and diabetes, Fraser, oral facial
digital and Ochoa syndromes, diseases associated with renal agenesis, dysplasia and cystic
disease.
● I also undertake genetic studies in non-syndromic common renal tract malformations such as
vesicoureteric reflux and pelvi-ureteric junction obstruction, and of rarer severe defects such as
non-syndromic kidney dysplasia, posterior urethral valves and persistent cloaca.
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2. PERSONAL DETAILS
Full Name
Adrian Spencer Woolf
Present Post
2010-present
Manchester Biomedical Research Centre Professor of Paediatric Science,
Developmental and Regenerative Medicine Research Group,
School of Biomedicine, Faculty of Medical and Human Sciences,
University of Manchester
Honorary Positions
2010-present
Honorary Consultant in Paediatric Nephrology, Royal Manchester Children‟s Hospital,
Manchester, UK
2010-present
Honorary Professor of University College London, UK
2010-present
Honorary Consultant in Paediatric Nephrology, Great Ormond Street Hospital for Children,
London, UK
Work address
Room D2515, Michael Smith Building, University of Manchester, Oxford Road, Manchester,
M13 9PT, UK
Email: adrian.woolf@manchester.ac.uk Telephone: +44 (0)161 275 1534
Website: http://www.medicine.manchester.ac.uk/staff/AdrianWoolf
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3. EDUCATION AND QUALIFICATIONS
Education
1968-1974 St Paul's School, London
1975-1978 Corpus Christi College, Cambridge
1978-1981 Westminster Medical School, London
Qualifications
1981 MB BS, University of London
1982 MA, University of Cambridge
1984 MRCP II UK
1989 MD Thesis, University of London
Courses attended in University College London and Great Ormond Street Hospital London
(from 2003)
● UCL Recruitment Training, 8 September 2003.
● GOSH Appraisal Training for Consultants, 12 September 2003.
● GOSH Moving and Handling Course, September 2003.
● UCL Racial Awareness Training, 3 February 2004.
● GOSH Consultants Update Programme (IT, medicines, risk management and clinical
governance, child protection, postmortem and consent, postgraduate medical education, infection
control and blood transfusion), 17 June 2004.
● GOSH Appraisal Training for Consultants, 28 July 2004.
● GOSH Resuscitation Training Update, Great Ormond Street Hospital, 26 August 2004.
● UCL/Imperial College London Senior Leadership Course, 17-18 January and 2 February 2005
● UCL Good Clinical Practice and the EU Clinical Trials Directive, 7 June 2005.
● UCL New Laws about Contract Obligations, 6 September 2005
● GOSH Consultants Update Programme (Information services, Medicines, Risk management,
Health and safety, Protecting together, Postmortem and consent, Blood transfusion, Infection
control), 6 December 2005.
● GOSH Moving and Handling Course, 12 December 2005.
● UCL Staff Development Reviewer/Reviewee Training Course (Dr SE Tarling) 22 June 2006
● GOSH Consultants Update Day; child protection; data protection and freedom of information;
Health, safety and risk management; Q&A with Chief Executive; Infection control; clinical audit;
fire prevention; waste management; glucometer; medicines management; blood products;
PGMA; Moving and Handling update. 27 March 2007
● UCL Essential HR for Research Managers/Principal Investigators (SB1). 12 June 2007
● London Technology Network - Assertiveness, Influencing, Negotiation & Conflict Handling
Workshop 19 July 2007
● GOSH Resuscitation Update – Great Ormond Street Hospital 16 August 2007
● GOSH Consultant update day. Great Ormond Street Hospital. Counter-fraud, Fires, Moving
and Handling, Medicines, Blood products, Bacteriology, Infection control 24 July 2008.
● Royal Veterinary School. Home Office Module 5. 5-6 February 2009.
● GOSH Resuscitation Update – Great Ormond Street Hospital 28 April 2009
● Royal Veterinary School. Home Office Module 4. 13 May 2009.
● University of Cambridge. Home Office Module 2/3 for Amphibia. 21 July 2009.
● University of Cambridge. Home Office Module 2/3 for Fish. 15 September 2009
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● Royal Veterinary School. Home Office Module 1 and Module 2/3 for Rodents. 19-20 October
2009.
● UCL Diversity in the Workforce Certificate. 2 December 2009
Courses attended in University of Manchester
● University of Manchester. Equality and Diversity Issues MS9. 14 January 2010.
● University of Manchester. Home Office Module 1/2 for rodents (talk-only for update) 19 April
2010 and approval for animal handling 23 April 2010.
● University of Manchester, Faculty of Medical and Human Sciences New Academics
Programme: Induction (6 May 2010); Research Excellence 1 (21 May 2010); Inspirational
Teaching 1 (2 June 2010); Personal Development 1 (23 June 2010); Research Excellence 2 (2
July 2010); Inspirational teaching 2 (14 July 2010); Personal and Professional Development 2
(17 September 2010); Media Training (4 October 2010); Research Ethics Applications (21
October 2010); Examinations and Viva of PhD/MD students (21 February 2011); RE7 21 st
Century Research Profiles (3 March 2011).
● University of Manchester, Recruitment and Selection Module 2 – Shortlisting and Interviewing
for Academic, Experienced staff. 4 June 2010.
● University of Manchester Training to be Academic Advisor (for the University of Manchester
medical course). 8 July 2010.
● Performance Development Review Reviewer Briefing (Academic; TAP5). 8 February 2011.
Courses attended in the Central Manchester Foundation Trust
● CMFT General Induction for staff (HR/Counter fraud/Health and Safety/Customer
care/Information governance/Safeguarding vunerable individuals/Equality and diversity/Fire
safety/Infection control/Responding to risk/Acting in emergencies and major
incident/Organisational development and training. 18 January 2010.
● CMFT Clinic Work Station and Medisec Discharge Notification Forms for Doctors Training
Modules and test. April 2010.
● CMFT Clinical Academic Supervisor Training Level 1 e-Learning Modules on: Introduction to
adult learning principles; Ethics and medical education; Mini-CEX and DOPS; Workplace based
teaching – clinical skill teaching; Workplace based teaching – six step microskill method;
Equality and diversity. 10 and 13 September 2010.
● CMFT eLearning Corporate Mandatory Training Programme Fire Safety Infection Prevention
and Control Customer Care Risk Management Security - Dealing with Violence and Aggression
Safeguarding Vulnerable Individuals Health and Safety Awareness Equality and Diversity. 14
September 2010
● CMFT Informed Consent On the Net – ICON. eLearning Modules 1-21 completed 27
September 2010
● Academic Supervision – Maximising Potential. Half day course. 29 September 2010.
● Manchester Children‟s Hospital Resuscitation Training 25 October 2010
● CMFT Patient Safety Training Day 1 November 2010
● CMFT Mandatory elearning Doctors Corporate Induction Programme; hospital at night; health
and safety awareness; fire safety; risk management; fraud in the NHS; equality and diversity;
customer care; acting in medical emergencies; and major incidents10 November 2010
● CMFT Mandatory Training elearning Consultants Clinical Children's Training Course Infection
Prevention and Control; Safeguarding Adults and Children; Medicines Management; Human
Tissue Act - Introduction/Research/Research Assessment/Human Application/Postmortem;
Early Warning Score; Blood Transfusion; Medical Devices 9 December 2010
● CMFT Good Clinical Practice. Research governance; Applications approvals; Informed
consent; Data management; Safety reporting; Monitoring. 10 January 2011.
● CMFT Mandatory Training Safeguarding Children (level 3). 28 March 2011
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4. PROFESSIONAL HISTORY
House Physician/Surgeon
August 1981 to July 1982 (12 months)
House Physician and House Surgeon, Westminster Hospital, London, UK
Three months in each of the following:
Orthopaedics;
General Surgery;
General Internal Medicine and Cardiology;
General Internal Medicine and Nephrology.
Senior House Officer
August 1982 to July 1984 (24 months)
Senior House Officer at Westminster, Guy's and St Paul's Hospitals, London and Peace
Memorial Hospital, Watford, UK
Six months in each of the following:
General Internal Medicine and Gastroenterology;
General Internal Medicine;
Neurology;
Nephrology (acute and chronic renal failure and renal transplantation)
Registrar
August 1984 to July 1986 (24 months)
Registrar in Medicine, Middlesex Hospital, London, UK
General Internal Medicine with specialist interests in Nephrology (e.g. chronic renal failure),
Calcium Metabolism and Hypertension relating to kidney disease.
Two outpatient clinics/week and 1:5 „on take‟ rota for General Internal Medicine.
August 1986 to June 1988 (23 months)
Research Registrar in Endocrinology, Whittington Hospital, London, UK
MD research on „Atrial Natriuretic Peptide in Renal Disease‟ with studies of patients with
nephrotic syndrome and chronic renal failure
One outpatient clinic/week.
July 1998 (1 month)
Locum Registrar in Nephrology, St Mary‟s Hospital, London, UK
Included all aspects of Acute Nephrology
Senior Registrar
August 1988 - January 1989 (6 months)
Locum Senior Registrar, University College Hospital, London, UK
General Internal Medicine and Nephrology
Two outpatient clinics/week
Care of patients with acute renal failure (e.g. In Intensive Care) and chronic renal failure,
nephrotic syndrome and performed renal biopsies
1:5 „on take‟ rota for General Internal Medicine
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4. PROFESSIONAL HISTORY (continued)
Senior Registrar (continued)
February 1989 to August 1989 (6 months)
Registrar in Nephrology, St Paul's and St Philip's Hospitals, London, UK
Included all aspects of Nephrology including biopsy, transplantation, peritoneal and
haemodialysis.
Two outpatient clinics/week.
September 1989 to September 1991 (25 months)
Research Fellow in Nephrology, Division of Nephrology, University of California in Los Angeles,
USA.
Extensive research experience in Nephrology as well as lecturing on renal physiology and
medicine.
October 1991 to March 1993 (18 months) Honorary Senior Registrar in Medicine, University
College Hospital, London, UK
General Internal Medicine with special interest in Hypertension
Two clinics/week and 1:5 „on take‟ rota for General Internal Medicine
Clinical Senior Lecturer and Honorary Senior Registrar
April 1993 to September 1994 (18 months)
Lecturer in Developmental Biology, Institute of Child Health, London and Honorary Senior
Registrar in Paediatric Nephrology, Great Ormond Street Hospital, London, UK.
Included three months as acting Paediatric Nephrology Registrar (acute and chronic renal failure,
dialysis, renal transplantation)
February 1994 to September 1994 (8 months)
Honorary Registrar, Royal Free Hospital
Undertook 1:5 „on call‟ rota covering the Paediatric Nephrology Unit (acute and chronic renal
failure, dialysis, renal transplantation)
Honorary Consultant
October 1994 to present
Honorary Consultant in Paediatric Nephrology, Great Ormond Street Hospital for Children NHS
Trust, London, UK.
Clinical Senior Lecturer
October 1994 to September 1997
Senior Lecturer in Developmental Biology, Institute of Child Health, London, UK
Reader
October 1997 to September 2000
Reader in Nephrology and Developmental Biology, Institute of Child Health, University College
London, London, UK.
Professor
October 2000 to December 2009
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Professor of Nephrology (and from 1998 Head of the) Nephro-Urology Unit, Institute of Child
Health, University College London, London, UK.
5. OTHER APPOINTMENTS AND AFFILIATIONS
Journal editorial experience
1996-2002 Assistant Editor of Pediatric Nephrology
1996-2001 Associate Editor of Experimental Nephrology
2001-2002 Deputy Editor of Experimental Nephrology
2001-2005 Editorial Board member of Journal of the American Society of Nephrology
2001-2010 Editorial Board member of Kidney International
2002-2007 Editor of Nephron Experimental Nephrology
2005-2007 Member of Faculty of 1000 – Medicine (Nephrology Section)
2005-present Editorial Board member of Journal of Paediatric Urology
2007-present Subject Editor for Paediatric Nephrology in Nephrology Dialysis and
Transplantation
Responsibilities in national societies
2000-2003 Research Secretary of the British Association of Paediatric Nephrology.
2000-2004 Honorary Secretary of The Renal Association, and Trustee/Director of The Renal
Association - this is the major society for all UK Nephrologists and I was the first Paediatric
Nephrologist to hold these positions. I manage thrice-yearly Executive Committee,
Trustees/Directors and Renal Registry Management meetings, twice-yearly Clinical Conferences,
and Annual General Meetings.
2004 Served on Working Party to re-configure Training, Education and Research in The Renal
Association.
2003 Renal Association Working Party for Training, Education and Research
2004 Renal Association/National Kidney Research Fund UK Renal Genetics Group
Member of professional bodies
American Society of Nephrology
Association of Physicians of Great Britain and Ireland
British Association for Pediatric Nephrology
European Society of Paediatric Nephrology
International Society of Nephrology
Royal College of Paediatrics and Child Health
The Renal Association
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5. OTHER APPOINTMENTS AND AFFILIATIONS (continued)
Academic review bodies
● 1996-2002 National Kidney Research Fund project grants and research fellowship committees.
● 2001 INSERM (National French Institute of Health) expert advisor.
● 2006 and 2007 Academy of Finland research grants external committee in Biomedicine.
● I have reviewed grant applications for charities including: Action Research, Biotechnology and
Biosciences Research Council, Dutch Kidney Foundation, Health Research Council of New
Zealand, Kidney Research UK, Medical Research Council, National Kidney Research Fund,
Royal Society, Scottish Hospitals Endowment Research Trust, Wellcome Trust.
● I have reviewed original research articles for the following journals: American Journal of
Pathology, American Journal of Physiology, Anatomy and Embryology, Bioessays, British Journal
of Urology, Development, Developmental Biology, Developmental Genetics, European Journal of
Human Genetics, European Journal of Pediatrics, European Journal of Pediatrics, Experimental
Nephrology, Gene Therapy, Histology and Histopathology, In Vitro, International Journal of
Experimental Pathology, Journal of Anatomy, Journal of the American Society of Nephrology,
Journal of Medical Genetics, Journal of Pediatric Urology, Journal of Physiology, Journal of
Urology, Kidney International, Lancet, Mechanisms of Development-Gene Expression Patterns,
Nature Clinical Practice Nephrology, Nature Genetics, Nature Medicine, Nephrology, Nephron,
Pediatric Nephrology, Pediatric Research, PLoS Biology, Prenatal Diagnosis, Proceedings of the
National Academy of Sciences USA
● Abstract reviewer for National and International Conferences: American Society of Nephrology
(1995, 1997, 1999, 2001, 2010); British Association for Paediatric Nephrology (1997, 2001, 2001,
2003); European Dialysis and Transplant Association (2007); European Kidney Research Forum
(1998); European Society for Pediatric Urology (2010, 2011); International Pediatric Nephrology
Association (1998); The Renal Association (1997, 1999, 2000, 2001, 2002, 2008, 2009, 2010;
2011); World Congress of Nephrology (2009).
Member of scientific organising committees
European Society of Paediatric Nephrology, Helsinki, Finland, 2000; 8th International Workshop
on Developmental Nephrology, Vancouver, Canada, 2001; 9th International Workshop on
Developmental Nephrology, Australia, 2004.
Chaired scientific sessions at national and international conferences
American Society of Nephrology (1997, 2002, 2006); British Association of Paediatric Nephrology
(1997, 2001, 2002); European Kidney Research Forum (1998); Renal Association (1998, 1999,
2000, 2001, 2002, 2003).
University of Manchester
Academic Representative of Child Health on the Council of the Section of Paediatrics,
Manchester Medical Society 2010-2011
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5. OTHER APPOINTMENTS AND AFFILIATIONS (continued)
Invited examiner: PhD/MPhil/MD theses
1998 PhD University of Melbourne, Australia: AT Clarke Studies on the role of transforming
growth factor-�1 and its receptors in kidney development
1998 PhD Chinese University of Hong Kong: TKW Herman Embryonic development of renal
agenesis in a retinoic acid-induced mouse model
1999 PhD Catholic University of Leuven, Belgium: PMA Groenen Genetic studies on renal
malformations
2000 PhD University of Hong Kong, China: LCW Davy RET receptor tyrosine kinase in
developing, adult and polycystic kidneys
2001 PhD. University of Melbourne, Australia: K Moritz Role of the renin-angiotensin system in
the fetal adrenal and kidney during the first half of gestation
2001 PhD University of Cambridge, UK: L Foggensteiner Biology of polycystin1 and polycystin2
2003 PhD Open University, UK: R Case Investigation of the structure and function of the PKD
domain of polycystin-1, the protein product of the PKD gene
2003 PhD. University of Edinburgh, UK: L Michael Specializations at the tips of a branching
epithelium
2003 PhD Aarhus University, Denmark: C Li Dysregulation of renal aquaporins and sodium
transporters in rats with urinary tract obstruction.
2004 PhD. University College Dublin, Ireland: V Dolan Gremlin and induced in high glucose-1:
two diabetic nephropathy associated genes with roles in development.
2004 PhD University of Cambridge, UK: S Mulroy Investigation of a mouse model of autosomal
dominant polycystic kidney disease generated by targeted disruption of the Pkd1 gene.
2004 MD. University of Leeds, UK: J Stahlschmidt Regulation and differentiation in normal and
neoplastic urothelium.
2005 PhD University of Sheffield, UK: L Newby Identification of ligands for the PKD1 protein,
polycystin 1, using genetically modified cells.
2006 PhD Open University, UK (Istituto di Richerche Farmacologiche Mario Negri, Italy): E
Gagliardini Role of nephrin in glomerular permselectivity
2006 PhD Open University, UK (Istituto di Richerche Farmacologiche Mario Negri, Italy): B
Imberti Bone-marrow stem cells to regenerate injured murine renal tissue.
2007 PhD Monash University, Australia: E Mitchell Structural and molecular studies on the
development of the mouse ureter and ureteric tree.
2008 PhD Imperial College London, UK: SK Harten Role of the von Hippel-Lindau tumour
suppressor gene in regulating renal epithelial cell characteristics.
2009 PhD University of Edinburgh, UK; N Lindstrom. Mechanisms of epithelial branching,
nephrogenesis, and the role of the Rho-GTPase family in kidney development.
2009 PhD University of Southern Denmark: K Madsen The renin angiotensin system and kidney
development: novel mechanisms of renin release and angiogenic function of angiotensin II.
2009 PhD University of Aarhus, Denmark; S. Topcu. Renal function in congenital urinary tract
obstruction: the importance of angiotensin II mediated hemodynamic and cellular changes in
response to unilateral neonatal obstruction.
2010 PhD University College London, UK: DH Shukla. Manipulation of the VHL/HIF pathway in
mouse kidney epithelia and pancreatic �-cells.
2011MPhil The Chinese University of Hong Kong, China: W Tang. An investigation of a novel
teratogenic mechanism of retinoic acid by a retinoic acid-induced renal agenesis model.
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6. PRIZES, AWARDS AND OTHER HONOURS
1970 Scholarship, St Paul's School, London
1975 Smyth Scholarship in Natural Sciences, Corpus Christi College, Cambridge
1979 and 1980 Prizes in Surgery, Chemical Pathology and Dermatology, Westminster Medical
School, London
1981 Honours in Medicine, MB BS, University of London
1989 Berkeley Travelling Fellowship, University College Hospital, London
1991 Senior Clinical Training Fellowship, National Kidney Research Fund
1994 Milne-Muehrcke Award, National Kidney Foundation, USA
1996-2002National Kidney Research Fund grants committee
1997 Fellow of the Royal College of Paediatrics and Child Health
1998 Best research presentation prize, 11th International Pediatric Nephrology Association
congress
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7. GRANTS
Main peer-reviewed grants
1989 Berkeley Travelling Fellowship, University College Hospital, London (£10,000). Principal
investigator AS Woolf. Creation of a chimeric kidney.
1991 National Kidney Research Fund Senior Fellowship, 91/2/90 (@£250,000). Principal
investigator AS Woolf. Creation of a genetically engineered mammalian kidney.
1993 Wellcome Trust Project Grant, 037428 (£204,000). Principal investigator LG Fine; coapplicant
AS Woolf. Cell lineage in the developing kidney.
1993 National Kidney Research Fund Project Grant, 92/2/49 (£64,000). Principal investigator AS
Woolf. Generation of cell lines from the H2-K b -tsA58 transgenic mouse.
1993 Central Research Fund, University of London (£2,000). Principal investigator AS Woolf.
Gene expression in human kidney malformations.
1994 British Heart Foundation Project Grant, 94061 (£70,000). Principal investigator AS Woolf.
Vascularisation of the embryonic kidney.
1996 Mainline Research Scheme, University of Hong Kong (£3,000). Principal investigators A
Shum and Gosling; co-applicant AS Woolf. Pathogenesis of the birth defect renal agenesis.
1997 Institute of Child Health Small Project Grant (£10,000). Principal investigator WG van't Hoff;
co-applicants S Haq and AS Woolf. Cloning and characterisation of proximal tubular epithelia
from urine of cystinosis patients.
1996 Wellcome Trust Project Grant, 049506 (£46,000). Principal investigator AS Woolf. Kidney
cell lineage.
1996 British Heart Foundation Project Grant, 96120 (£92,000). Principal investigator AS Woolf.
Vascularisation of the embryonic kidney.
1996 National Kidney Research Fund Project Grant, R11/2/96 (£65,000). Principal investigator
AS Woolf; co-applicants MA Hanson, P Mouriquand and P Foxall. Cell biology of obstruction of
the fetal sheep kidney.
1997 Action Research Project Grant, S/P/3178 (£76,380). Principal investigator AS Woolf; coapplicant
PJD Winyard. Cell biology of human multicystic dysplastic kidney malformations.
1998 National Kidney Research Fund Project Grant R34/1/98 (£75,000). Principal investigator S
Malcolm; coapplicants AS Woolf and SA Feather. Genetics of human primary vesicoureteric
reflux and its associated nephropathy.
1998 National Kidney Research Fund Research Studentship. S10/98 (£36,000). Principal
investigators AS Woolf and PJD Winyard. Galectin-3 and renal tubular morphogenesis.
1999 Wellcome Trust Project Grant 058005 (£102,799). Principal investigator AS Woolf.
Angiopoietins and the Tie-2 receptor in renal endothelial development.
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7. GRANTS (continued)
Main peer-reviewed grants (continued)
1999 National Kidney Research Fund Project Grant R3/2/99 (£31,400). Principal applicant AS
Woolf; co-applicant PJD Winyard. Does galectin-3 modulate cyst formation in the cpk model of
autosomal recessive polycystic kidney disease?
1999 Medical Research Council Research PhD Studentship (£36,000). Principal investigators AS
Woolf and DA Long. Growth factors and the kidney vasculature.
2000 National Kidney Research Fund Project Grant R11/1/2000 (£74,838). Principal investigator
SA Feather; co-applicants AS Woolf and S Malcolm. The search for the gene responsible for
vesicoureteric reflux and reflux nephropathy on chromosome 1.
2000 National Kidney Research Fund Project Grant R18/1/2000 (£73,592). Principal investigator
PJD Winyard; co-applicant AS Woolf. Roles of urinary tract obstruction, PAX2 and transforming
growth factor �1 in the pathogenesis of human dysplastic kidneys.
2000 National Kidney Research Fund Research PhD Studentship ST1/2000 (£40,000).
Application by AS Woolf and S Malcolm.
2001 Action Research Project Grant (£125,000) Principal investigator SA Feather; co-applicants
S Malcolm and AS Woolf. Genetics and biology of the oral facial digital syndrome type 1:
relevance to normal development and polycystic kidney disease.
2001 National Kidney Research Fund Project Grant R16/1/2001 (£46,156) Principal investigator
AS Woolf; co-applicant A Wade. Effects of low protein diets on early nephrogenesis.
2001 National Kidney Research Fund Project Grant R4/2/2001 (£96,672) Principal investigator
AS Woolf; coapplicant HT Yuan. Angiopoietin-2 and kidney vascular development.
2002 National Kidney Research Fund Studentship ST3/2002 (£50,000). Application by AS Woolf
and PJD Winyard.
2002 Medical Research Council Research PhD Studentship G78/7766 (£40,000). Theme
studentship awarded to D Jenkins with AS Woolf primary supervisor. The genetics and
developmental biology of vesicoureteric reflux
2002 Wellcome Trust Functional Genomics Programme Grant (total £270,000 of which £170,000
to AS Woolf) Principal investigaotors AS Woolf and THJ Goodship; coapplicants S Malcolm, SA
Feather and JA Goodship. Vesicoureteric reflux in the United Kingdom – establishing a DNA
collection for affected families. 01NU29
2003 Kidney Research Aid Fund project grant (£104,218) Coapplicants-coinvestigators Principal
investigaotor AS Woolf; coapplicants M Bitner-Glindzicz, DT Wilcox, SM Whitten and D Jenkins.
Genetics of malformations of the human kidney and lower urinary tract.
2003 Kidney Research Aid Fund project grant (£62,658) Principal applicant MK Farrugia;
coapplicants AS Woolf and PM Cuckow. A model with which to understand the basis of fetal
urinary bladder outflow obstruction.
2004 Kidney Research Aid Fund Project Grant. (£34,717) Principal investigator MK Farrugia; coapplicants
AS Woolf and PM Cuckow. A model with which to understand the urodynamics of fetal
bladder outlet obstruction.
15

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7. GRANTS (continued)
Main peer-reviewed grants (continued)
2004 Biotechnology and Biological Sciences Research Council. PhD Studentship. S04/G163
(£37,500) Principal investigator AS Woolf; co-applicant H Skaer. Genetic regulation of
mesenchymal-epithelial precursor cell transformations in mammalian and fly kidneys.
2004 Wellcome Trust Project Grant. 073624 (£198,796) Principal investigators AS Woolf and PJ
Scambler. Defining roles for Fras1, a Fraser syndrome gene, in mouse metanephrogenesis.
2004 National Kidney Research Fund Start-Up Grant RP20/1/2004 (£30,000). Principal applicant
J Southgate; co-applicants AS Woolf, D Jenkins, M Bitner-Glindzicz and SA Feather. Functional
analyses of uroplakin gene mutations; implications for differentiation of the urinary tract.
2004 Wellcome Trust Project Grant. 075311 (£226,547) Principal investigator AS Woolf; coapplicants
AM Fry and SA Feather. OFD1, a centrosomal protein mutated in human polycystic
kidney disease: an investigation of its role in kidney growth and differentiation’.
2005 Kidney Research Aid Fund/Kids Kidney Appeal Project Grant (£62,676). Co-applicant DA
Long. Angiopoietin as a therapy for acute renal disease
2005 National Kidney Research Fund PhD Studentship ST1/2005 (£50,084). Principal applicant
AS Woolf,. A study of candidate molecules which modulate dietary programming of early
nephrogenesis.
2005 Kidney Research Aid Fund/Kids Kidney Appeal Project Grant (£54,144). Principal applicant
Dr S Marks; co-applicants Dr K Tullus, Ms E Brennan, Professor AS Woolf. Childhood renal
artery stenosis: a familial study and establishment of a DNA bank.04NU33.
2006 Medical Research Council (£547,276: £25,000 direct allocation to UCL ICH via Newcastleupon-Tyne
Medical School). G0600040. SNP based sib-pair linkage study to identify loci
contributing to vesicoureteric reflux and its associated nephropathy. Principal applicant JA
Goodship; co-applicants HJ Cordell, TH Goodship, SA Feather, RB Kenda and AS Woolf.
05NU10.
2006 Kids Kidney Research (£85,940) Exploring how vascular endothelial growth factor
enhances the growth and differentiation of the embryonic urinary bladder. Principal applicant AS
Woolf; co-applicant DA Long. 06NU10
2007 British Council (£2,100) Investigating the roles of Teashirt transcription factors in the
developing and injured/regenerating mouse renal system. Principal applicant Professor AS
Woolf; co-applicant Ms C Gannon.
2007 Kids Kidney Research (£29,510). Roles for Tbx1 in normal and abnormal renal tract
morphogenesis ? Principal applicant Professor AS Woolf; co-applicants Professor PJ Scambler
and Dr JE Pitera. 07NU04.
2008 Wellcome Trust (£301,577) Roles for Fras1, a basement membrane-associated protein, in
normal differentiation of kidney collecting ducts and glomeruli. Principal applicant Professor AS
Woolf; co-applicants Professor PJ Scambler and Dr JE Pitera 07NU27/085077/Z/08/Z.
2008 Kidney Research UK (£56,421) Gene profiling in renal agenesis. Principal applicant
Professor AS Woolf; co-applicants Professor PJ Scambler and Dr JE Pitera. 08NU07-RP35/2008
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7. GRANTS (continued)
Main peer-reviewed grants (continued)
2008 Diabetes UK (£249,902) The role of angiopoietin growth factors in diabetic nephropathy.
Principal applicant Dr L Gnudi (King‟s College London), co-applicants Dr DA Long and Professor
AS Woolf. 08NU19.
2009 Kids Kidney Research (£99,150) Targeting blood vessels to prevent polycystic kidney
disease. Principal investigator Dr DA Long, co-applicants Dr PJ Winyard and Professor AS
Woolf.
2009 Kids Kidney Research (£70,100) Comprehensive genetic screening of patients with renal
malformations: a pilot study. Principal investigator Dr D Bockenhauer, co-applicants Professor
Klata (Royal Free Hospital), Professor AS Woolf and Dr S Adalat.
2010 Kids Kidney Research (£99,633) Defining kidney expression of Teashirt genes in health,
injury and regeneration. Principal investigator Professor AS Woolf.
2010 Kidney Research UK (£179,587) Uro-facial syndrome (UFS): a novel genetic model to
understand human renal tract function and malformation. Principal investigator Dr William G.
Newman, co-applicants Professor AS Woolf, Dr E McKenzie and Dr E Hilton.
2011 BBSRC Research Council DTG PhD Studentships 2011/12 Faculty of Medical and Human
Sciences (£76,337) The renal glomerulus as a model of extracellular matrix production in
differentiation and normal ageing. Principal applicant Dr R Lennon; co-applicant Professor AS
Woolf
2011 Kids Kidney Research PhD Studentship (£99,226) Proteomic analyses of kidney glomerular
extracellular matrix in health and disease Principal applicant Dr R Lennon; co-applicant Professor
AS Woolf.
2011 Kidney Research UK (£99,944) Restoring the angiopoietin balance as a therapy for
glomerular disease. Principal applicant Dr DA Long; co-applicants Professor AS Woolf and
Professor L Gnudi
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7. GRANTS (continued)
Research Training Fellowships and Studentships awarded to members of Professor
Woolf's research group
Paula R Towers. 1993 Medical Research Council Studentship (£40,000) The RET receptor and
kidney development
Paul JD Winyard. 1994 Action Research Training Fellowship (£110,000) Biology of Kallmann's
syndrome; and 1997 Institute of Child Health and Great Ormond Street Hospital Lectureship in
Paediatric Clinical Science (four years salary)
Catherine M Cale. 1995 Action Research Training Fellowship (£80,000) Inflammatory mediators
in renal development
Sally A Feather. 1996 Action Research Training Fellowship (£110,000) Genetics of renal
malformations; and 1999 Institute of Child Health and Great Ormond Street Hospital Lectureship
in Paediatric Clinical Science (four years salary)
MR (Shuman) Haq. 1998 Great Ormond Street Hospital and Institute of Child Health Science
Development Initiative Research Training Fellowship (£107,000) Cloning and characterisation of
proximal tubular epithelia from urine of cystinosis patients
Naima Smeulders. 2000 Action Research Training Fellowship (£100,000) Effects of stretch on the
cell biology of the developing bladder
Nikesh Thiruchelvam. 2001 Royal College of Surgeons of England Research Training Fellowship
(£40,000) Effects of in utero outflow obstruction on the developing urinary bladder
Liam SL McCarthy. 2002 Institute of Child Health, London, Springboard Fellowship (£130,000)
Integrins in detrusor development
Larissa Kerecuk. 2007 Medical Research Council Clinical Training Fellowship. FIS ref 11707
(£147,263) Exploring the expression and potential roles of Fras1 and Frem2 in models of kidney
diseases affecting the collecting duct lineage. 06NU12
Michiel Schreuder. 2008 European Renal Association (@£25,000) Modelling fetal kidney
programming ex vivo
David A Long. 2008 Kidney Research UK Senior Non-Clinical Fellowship. (£319,578) Roles of
angiopoietins in epithelial-endothelial interactions: using the renal glomerulus as a model system.
Shazia Adalat. 2009 NIHR via ICH/GOSH Biomedical Research Centre Clinical Research
Associate Fellowship (£157,598). The genetic basis of human non-syndromic renal tract
malformations. 08NU18.
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8. LECTURES AT MAJOR NATIONAL AND INTERNATIONAL MEETINGS
Can we cure kidney malformations? British Paediatric Association, Warwick, UK, 1994
Therapies for polycystic kidney diseases, 3 rd European Polycystic Kidney Workshop, Leiden,
Netherlands, 1994
Biology of kidney malformations. 10 th Congress of the International Paediatric Nephrology
Association, Santiago, Chile, 1995
Kidney malformations - what goes wrong and why it goes wrong. Renal Association, London,
UK, 1995
Renal genesis and dysgenesis. National Kidney Foundation, New York, USA, 1995
Dysplastic kidneys. European Society for Paediatric Urology, London, UK, 1996
Dysplastic kidneys - immature or just plain mixed up? British Paediatric Association, York, UK,
1996
Relevance of kidney development to practice of nephrology. Royal Society of Medicine, London,
UK, 1996
Hepatocyte growth factor/met and mesenchyme/epithelial interactions. American Society of
Nephrology, New Orleans, USA, 1996
Mesenchymal-epithelial induction. American Society of Nephrology Advances in Basic Science
Conference, New Orleans, USA, 1996
Biology of renal malformations. German Speaking Society for Paediatric Nephrology, Zurich,
Switzerland, 1997
Cytokines and renal differentiation. 14 th International Congress of Nephrology, Sydney,
Australia, 1997
Normal kidney development and mistakes that lead to congenital nephropathies. XXIVth
Congress of European Dialysis and Transplant Association, Geneva, Switzerland, 1997
Receptor tyrosine kinases in epithelial and endothelial differentiation in the metanephros. Stem
Cell Growth and Manipulation Symposium, Wuerzburg, Germany, 1997
The enigma of human kidney malformations. Festschrift for Prof TM Barratt, London, UK, 1997
Kidney development. Advanced Neonatology course, Queen Charlotte's and Chelsea Hospital,
London, UK. 1998
Mechanisms of human kidney malformations. Developmental Pathology Society, Canterbury,
UK, 1998.
Advances in the cellular and molecular biology of kidney malformations. Genes, Embryos and
Birth Defects, London, UK. 1998
The development of the kidney. 2 nd UK Nephrology Summer School, London, UK, 1998
Renal endothelial differentiation and Tie receptor tyrosine kinase signalling. 7 th International
Workshop on Developmental Biology, Stockholm, Sweden, 1998.
Cell culture and communication - the origins of kidney epithelia and endothelial cells. 11 th
Congress of the International Pediatric Nephrology Association, London, UK, 1998.
Molecular bases of kidney malformations. 3 rd Meeting of Pediatric Nephrology, Verona, Italy,
1998.
Molecular and morphological bases of renal development. 13 th INSERM Seminar in
Fundamental Nephrology, Paris, France, 1998.
Molecular lesions in human renal malformations. Princess Liliane Symposium, Brussels,
Belgium, 1998
Genetics of reflux nephropathy and renal dysplasia Renal Association Advanced Nephrology
Course, London, UK, 1999.
Reflux nephropathy. Advanced Medicine Conference, Royal College of Physicians, London, UK,
1999.
Tie receptors and renal endothelial development. Mount Sinai and Albert Einstein Schools of
Medicine, New York, USA, 1999
Development of normal and cystic renal epithelia. 15 th International Society of Nephrology,
Buenos Aires, Argentina, 1999
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Mechanisms of human kidney malformations. Necker Seminar in Nephrology, Paris, France,
1999.
8. LECTURES AT MAJOR NATIONAL AND INTERNATIONAL MEETINGS (continued)
Fetal development and renal function. Rank Prize Funds Symposium on Nutrition and the
Kidney, Lake District, UK, 1999
Human renal malformations. 7 th Leicester Paediatric Nephro-Urology Symposium, Leicester,
UK, 1999
Mouse models of renal diseases. International Symposium in Mouse Pathology, Helsinki,
Finland, 1999
Genes which regulate the development of the kidney and urinary tract. 36 th Congress of
European Dialysis and Transplant Association, Madrid, Spain 1999
Tie receptor tyrosine kinases and kidney vessel development. American Society of Nephrology
Basic Science Symposium, Miami, USA, 1999.
Mechanisms of kidney organogenesis and Mouse models of human kidney malformations. 1 st
Developmental Biology and Dysmorphology Course, European Genetics Foundation, Sestri
Levate, Italy, 1999.
Is there a genetic basis for vesicoureteric reflux and its nephropathy? 34 th European Society of
Paediatric Nephrology, Helsinki, Finland, 2000.
The life of the human kidney before birth. 50 th Meeting Renal Association, Cambridge, UK,
2000.
Cell turnover in normal and abnormal kidney development. 3 rd Japanese-European Nephrology
Forum: Developmental Nephrology and Renal Engineering, Tokyo, Japan 2001.
Renal vascular differentiation in health and disease. European Society of Paediatric Urology,
Aarhus, Denmark, 2001.
Dysplastic kidneys – Immature or just mixed-up? 8 th International Workshop on Developmental
Nephrology, Victoria, British Colombia, Canada, 2001.
Advances in genetics and treatment of primary vesicoureteric reflux and its associated
nephropathies. 12 th International Paediatric Nephrology Association congress. Seattle, USA,
2001.
The basis of fetal obstructive nephropathy. Congress of the Italian Society of Paediatric
Nephrology and Paediatric Urology, Rome, Italy, 2001.
Reflux nephropathy. Renal Association Advanced Nephrology course, London, UK, 2002.
Vesicoureteric reflux and associated nephropathies: advances in genetics and surgery. Royal
Society of Medicine, Paediatric Section, London, UK, 2002.
Genetic bases of congenital uropathies and nephropathies. Arbeitsgemeinschaft fur
Padiatrische Nephrologie, Essen, Germany, 2002.
Genetics of vesicoureteric reflux and renal dysplasia. Royal Society of Medicine, Nephrology
and Urology Section, Section, Birmingham, UK, 2002.
Effect of maternal diet on the biology of very early kidney development. 34th Congress of the
European Renal Association and the European Dialysis and Transplant Association,
Copenhagen, Denmark, 2002.
Apoptotic death in congenital kidney disease. World Congress of Nephrology, Berlin, Germany,
2003.
Cell suicide as a common mechanism of diverse kidney malformations. 5 th World Congress on
Urological Research, London, UK.
A molecular and genetic view of human renal and urinary tract malformations. American Society
of Nephrology, San Diego, 2003.
Maternal diet affects embryonic kidney gene expression. 5 th Japan-Europe Nephrology Forum,
Hakone, Japan.
Role of hypoxia and angiogenesis in renal disease. 36 th Congress of the European Renal
Association and the European Dialysis and Transplant Association, Lisbon, Portugal, 2004.
Initiation of the Renal Vasculature. Symposium on New Paradigms in Vascular Biology: Renal
Implications, American Society of Nephrology, St Louis, 2004
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Manipulating kidney differentiation. Kidney International Nephrology Forum, The Renal
Association. Belfast. 2005.
8. LECTURES AT MAJOR NATIONAL AND INTERNATIONAL MEETINGS (continued)
Molecular and genetic analyses of renal capillary development. International Society of
Nephrology, Forefront in Nephrology, Symposium on Stem Cell and Regeneration of the Kidney.
Karuizawa, Japan, 2005.
Future perspectives in genetics of paediatric urology. European Society for Pediatric
Urology/American Academy of Pediatrics. Uppsala, Sweden. 2005.
Understanding vesicoureteric reflux and associated nephropathies. Paediatric Nephrology for
the General Paediatrician. ICH Institute of Child Health London, UK. 2005.
Fraser syndrome, FRAS1 and metanephric development. American Society of Nephrology,
Philadelphia, USA. 2005.
FRAS/FREM gene mutations cause human and mouse Fraser syndromes and lead to early
death of the metanephros. EuReGene Symposium on Renal Development, Berlin, Germany.
2006.
Teratogens, maternal environment and fetal kidney growth. Continuing Education Programme in
Paediatric Nephrology and Urology, UCL Institute of Child Health London, UK. 2006.
FRAS and FREM gene mutations cause human and mouse Fraser syndromes and lead to a
range of renal malformations. Fourth Course on Genetics and Renal Diseases, Genova, Italy.
2006.
Human renal tract malformations: unraveling the genes. XLIII Congress European Renal
Association and the European Dialysis and Transplant Association, Glasgow, UK. 2006.
Orchestrating kidney development: messages from the clinic. XLIV Congress European Renal
Association and the European Dialysis and Transplant Association, Barcelona, Spain. 2007
Developmental biology of renal tract malformations: lessons for Paediatricians. The Catherine
Chisolm Lecture at the Manchester Medical Society, Manchester, UK. 2007.
Human renal dysplasia syndromes: mixing cell biology and genetics. XLV European Renal
Association- European Dialysis and Transplant Association Congress, Stockholm, Sweden.
2008.
Uroplakins: key players in renal tract development. British Renal Society/Renal Association
joint conference, Glasgow, UK. 2008.
New molecular players in the biology of urinary tract malformations. Plenary lecture.
European Society for Paediatric Nephrology, Lyon, France, 2008.
Transition to adult care for children with renal tract malformations. Royal College of Physicians
of Edinburgh, Edinburgh, UK, 2008.
Renal involvement in patients with hepatocyte nuclear factor-1B mutations. Spanish Society of
Nephrology, San Sebastian, Spain 2008.
Ureter development – mouse models. Rayne Foundation, Course in Pediatric Urology, Shaare
Zedek Medical Center, Jerusalem, Israel, 2008.
Genetics and counseling in congenital urinary anomalies. Rayne Foundation, Course in Pediatric
Urology Shaare Zedek Medical Center, Jerusalem, Israel, 2008.
Congenital kidney malformations: don’t forget the ureter. World Congress of Nephrology, Milan,
Italy, 2009.
Development of the renal-urogenital system. 5 th International Course on Genetics and Renal
Disease, Genova, Italy, 2009.
Vesicoureteric reflux and genetics. International conference on vesicoureteral reflux in children.
Goteborg, Sweden, 2009.
Genes which control morphogenesis and functional maturation of the mammalian ureter.
KIDSTEM International Conference. Edinburgh, UK, 2009.
Smooth Muscle Dysplasia of the Ureter. NIH Symposium on Renal Tract Malformations.
Washington DC, USA, 2009.
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8. LECTURES AT MAJOR NATIONAL AND INTERNATIONAL MEETINGS (continued)
Reflux Nephropathy and other developmental disorders of the renal tract. The Renal Association
60 th Anniversary Symposium. Manchester, UK, 2010.
Fetal programming: from gene to function. American Society of Nephrology, Denver, USA,
2010.
Genetics of renal agenesis and dysplasia. 2 nd Joint Meeting of the The Renal Association and
Société de Néphrologie: Entente Cordiale. Paris, France, 2011
Fetal programming of polycystic kidneys ADPKD in Europe: clinical and experimental research”
Berlin, Germany, 2011.
Environmental influences on renal tract development. Padriatrietag, Bamberg, Germany, 2011.
Matrix molecules and human renal malformations: the Fraser and Ochoa syndromes. First AMG
Genetic Symposium on the Genetics of Ciliopathies and Renal Diseases, Utrecht, The
Netherlands.
To be presented
Human kidney malformations: lessons from two renal-genetics clinics. 44th Annual ESPN
Meeting, Dubrovnik, Croatia, 14 - 17 September 2011.
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9. ACADEMIC SUPERVISION
* indicates AS Woolf was primary supervisor
PhD Theses completed and awarded with subsequent appointments
* Maria Kolatsi-Joannou (1993-1996) University of London PhD awarded 1996: Hepatocyte
growth factor/scatter factor and renal morphogenesis. 1996 Appointed as postdoctoral research
assistant, Neural Development Unit, UCL Institute of Child Health.
* Paula R Towers (1993-1997) University of London PhD awarded 1998: The role of glial cell linederived
neurotrophic factor signalling pathway in mammalian organogenesis. 1997 Appointed as
postdoctoral research assistant, National Institute of Medical Research, London.
* Paul JD Winyard (1993-1997) University of London PhD awarded 1998: The biology of kidney
malformations. 1997 Appointed as Lecturer in Paediatric Clinical Science. Currently, Senior
Lecturer and Head of Learning and Teaching, UCL Insititute of Child Health.
* Catherine M Cale (1995-1998; cosupervisors Dr G Morgan and Dr N Klein). University of
London PhD awarded 1998: Inflammatory mediators and abnormal renal development. 1998
Appointed Specialist Registrar in Immunology. Currently, Consultant in Immunology at Great
Ormond Street Hospital.
Sally A Feather (1996-1999; cosupervisor Professor S Malcolm). University of London PhD
awarded 1999: Genetics of renal malformations. Subsequently, Lecturer in Paediatric Clinical
Science, UCL Institute of Child Health. Currently, Consultant in Paediatric Nephrology, St
James‟s University Hospital, Leeds.
Tanya Johnson (1998-2001; cosupervisor Dr PJD Winyard) University of London PhD awarded
2001: The biology of galectin-3 in normal and cystic renal development. 2001 She was awarded
UCL Bogue Travelling Fellowship to study at Columbia University, New York, USA. 2002
Research manager Glaxo-Wellcome.
* David A Long (1999-2003; cosupervisor Dr HT Yuan) University of London PhD awarded 2003:
Growth factors and the kidney vasculature. Subseqeuntly UCL Bogue Travelling Fellow,
Universities of Houston and Gainesville. Currently, Kidney Research UK Senior Fellow at the
Nephro-Urology Unit, UCL Institute of Child Health
* Dagan Jenkins (2002-2005; cosupervisors Dr Bitner-Glindzicz, Professor S Malcolm and Dr SA
Feather) PhD: Genetics of human renal tract malformations. 2005 Postdoctroral fellow,
Weatherall Institute of Molecular Medicine, University of Oxford, UK.
* Liam S McCarthy (2001-2004; primary supervisor after Mr DT Wilcox moved to USA) PhD:
Extracellular matrix biology in normal and abnormal bladder development. Currently, Consultant
in Paediatric Urology, Birmingham Children‟s Hospital.
Miliyun Chiu (2003-2006; cosupervisor Dr PJD Winyard) PhD: Galectin-3 and the development
of autosomal recessive polycystic kidney disease. Subsequently, Management Consultant trainee
in the City of London.
* Claire M Lye (nee Gannon) (2004-2007; cosupervisors Dr H Skaer and Prof PJ Scambler) PhD:
Teashirts in the mammalian urinary tract. Subsequently, postdoctoral scientist, University of
Cambridge.
23

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9. ACADEMIC SUPERVISION (continued)
* indicates AS Woolf was primary supervisor
MD Theses completed and awarded with subsequent appointments
* Naima Smeulders (1999-2002; cosupervisor Mr DT Wilcox) University of Cambridge MD
awarded 2002: The cell biology of the developing mouse detrusor muscle. 2002 Undertook SpR
training in Paediatric Surgery/Urology.
* Nikesh Thiruchelvam (2001-2003; cosupervisors Mr PM Cuckow, Professor C Fry) University of
London MD awarded 2003: Effects of experimental outflow obstruction on the developing
bladder. 2003 Took up the Wessex Urology SpR Training Programme.
* Marie-Klaire Farrugia (2003-2005; cosupervisors Mr PM Cuckow and Professor C Fry) MD:
Short-term fetal bladder outflow obstruction in the ovine model: bladder morphology, physiology
and in-utero urodynamics. 2005 Joined Paediatric Surgery clinical training programme.
MSc Theses completed and awarded with subsequent appointments
* Rehab Attar (1996-1997) University of London MSc awarded 1997: Cell biology of obstruction of
the fetal sheep kidney. 1997 She returned to Saudi Arabia to finish Surgical training.
* Fabienne Smith (2000-2001) University of London MSc awarded 2001: Antenatal detection of
kidney and lower urinary tract malformations in children with chronic renal failure: a retrospective
study. After, she returned to Paediatric clinical training.
PhD Theses in progress
* Shun Kai Chan (2005-present; cosupervisor Dr PR Riley) PhD: Effects of corticosteroids on
kidney development (being written-up)
Jennifer Huang (2009-present; co-supervisors Dr DA Long and Dr PJ Winyard) Targeting blood
vessels to prevent autosomal recessive polycystic kidney disease.
Shazia Adalat (2009-present; co-supervisors Dr D Bockenhauer and Prof R Kleta) The genetic
basis of human non-syndromic renal tract malformations.
MD Theses in progress
* Larissa Kerecuk (2007-present; co-supervisor Prof PJ Scambler) Exploring the expression and
potential roles of Fras1 and Frem2 in models of kidney diseases affecting the collecting duct
lineage. (being written-up)
MPhil in progress
* Helen M. Stuart (2011-present; co-supervisor Dr W Newman) Understanding genetic causes of
renal tract anomalies.
Non-submitted theses
MR (Shuman) Haq (1997-2001; cosupervisor Dr WG van't Hoff) PhD: Biology of nephropathic
cystinosis.
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9. ACADEMIC SUPERVISION (continued)
Supervised Visiting/Travelling Research Fellows
Berk Burgu (2004-2005; joint supervisor, Mr DT Wilcox). For his research, Dr Burgu was
awarded „Best EUSP Scholar 2005‟ by the European Urological Scholarship Programme
sponsored by the European Association of Urology.
* Michiel Schreuder (2007-present). From the Erasmus MC-Sophia Children‟s Hospital,
Rotterdam, The Netherlands.
Supervised 3 rd Year BSc Projects
* Christopher G Scott (1997) UCL BSc. The effects of retinoic acid on early development of the
mammalian kidney.
* Prital Patel (2004-2005) UCL BSc. The relationship between hypoxia and vascular endothelial
growth factor in the developing embryo..
* Aliyah Madhany (2004-2005) UCL BSc. The expression of sonic hedgehog signaling genes in
human kidney development
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10. TEACHING ACTIVITY
Major meetings organised at the Institute of Child Health
I direct the Continuing Education Programme in Paediatric Nephrology and Urology, an annual
event (which I have directed since 1998) which lasts one week and transmits advances in clinical
and science aspects to clinical trainees and consultants. The current programme is available at
http://www.ich.ucl.ac.uk/education/short_courses/courses/2S_57
In 1994 I initiated a Kidney Development Workshop which has been held annually and brings
together scientists and clinicians interested in normal and abnormal kidney development. These
meetings attract up to 50 attendees who can present work-in-progress. The following Workshops
were held at the Institute of Child Health: 1994, 1995, 1997, 1999; 2005 and 2007.
In 2006, I organised and hosted a Wellcome Trust-sponsored one day symposium called
“Vesicoureteric reflux and the genetics of renal development”.
Teaching and supervision of research staff
Since moving to the Institute of Child Health in 1993, I have encouraged both clinical fellows and
graduate student scientists to work in my laboratory research group. The clinical and science
students who have successfully completed their theses and obtained higher degrees, number
eleven PhDs (M Kolatsi-Joannou, P Towers, PJD Winyard, C Cale, SA Feather, T Johnson, D
Long, L McCarthy, D Jenkins, M Chiu and C Lye), three MD theses (N Smeulders, N
Thiruchelvam and MK Farrugia) and two MSc theses (Drs R Attar and F Smith). Currently, I
supervise one PhD student (S-K Chan) and two MD Res students (D Desai and L Kerecuk).
With regard to basic scientists, three Medical Research Council and three National Kidney
Research Fund/Kidney Research UK studentships have been held by basic scientists in my
research laboratory. One of my postdoctoral research assistants, Dr HT Yuan, was promoted to a
Lecturer at the UCL ICH in 2000 (subsequently moving to Harvard, USA), and another, Dr S
Loughna, was appointed as a Lecturer in Developmental Biology in the University of Nottingham
in 2001. Dr D Long and Dr T Johnson were awarded UCL Bogue Fellowships to further their
research in the USA, with Dr DA Long returning and being awarded a Kidney Research UK
Senior Fellowship.
With regard to the clinical fellows, I have been successful in helping them to write applications for
research, with four Action Research, one Medical Research Council, one National Kidney
Research Fund, and one Royal College of Surgeons (England) clinical training fellowships
obtained. Two of these individuals (Dr PJD Winyard and Dr SA Feather) became Lecturers in
Paediatric Clinical Science at UCL ICH and continued research in the biology and genetics of
kidney malformations; Dr PJD Winyard is currently Head of Learning and Teaching at UCL ICH.
Other teaching activities
I chair Wednesday Lunchtime Clinical Presentations at Great Ormond Street Hospital (2001present),
a teaching forum for clinicians and nurses.
I helped to initiate, and currently chair, Nephrology „Bipartite‟ meetings which provide a forum for
exchange of clinical cases and research from Great Ormond Street Hospital, and local Adult
Nephrology centres including University College and Royal Free Hospitals.
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11. ENABLING ACTIVITY
Institute of Child Health and Great Ormond Street Hospital NHS Trust
1994-present Unit Genetic Manipulation Safety representative
1994-2009 Attend weekly meetings for Nephrology Clinical Unit Senior Staff
1997-2001 Chair weekly meetings for Nephro-Urology Unit Senior Staff
1997-2010 Head of the Academic Nephro-Urology Unit
1997-2000 Attend regular meetings for Heads of Unit in Congenital Anomaly Theme
1997-2009 Member of Research Degrees Committee (2-3 meetings/year)
1998 Working Party on the Chair on Human Genetics
1998-2003 Member of Local Animal Ethical Committee
2001-2008 Chair Clinical Teaching Meetings (weekly) at Great Ormond Street Hospital
2001-2008 Chair joint ICH/GOSH Grand Rounds (monthy)
2002-2003 Library Committee member.
2003-2004 Member of Institute of Child Health Joint Research and Strategy Committee
2003-2009 Chair Nephro-Urology Unit Research and Development monthly meetings
University of Manchester
2010-present Member of the Children‟s Research Committee, Royal Manchester Children‟s
Hospital.
Miscellaneous Other Activity
In 1998 I acted as a spokesperson for an awareness campaign for the National Kidney Research
Fund involving television, radio and newspaper interviews.
I served on the Organising/Scientific committees for the International Workshop on
Developmental Nephrology, held in 2001 and 2004.
From 1998-2002 I acted as the Academic Representative for Training in Paediatric Nephrology in
the Royal College of Paediatric and Child Health Speciality Advisory Committee (CSAC).
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12A. PUBLICATIONS – EDITED BOOKS
Vize PD, Woolf AS, Bard JBL. The Kidney: from normal development to congenital abnormalities.
Elsevier Science/Academic Press, 1-519, 2003.
Chitty L, Woolf AS. Guest Editors. Perinatal renal disease. Seminars in Fetal and Neonatal
Medicine. 13: in press.
12B. PUBLICATIONS – CHAPTERS IN BOOKS
1. Fine LG, Kurtz I, Woolf AS, Danovitch GM, Emmons C, Kujubu DA, Norman JT.
Pathophysiology and nephron adaptation in chronic renal failure. In Diseases of the Kidney Ed.
Schrier and Gottschalk. Little and Brown, Boston, USA. 2703-2742, 1992.
2. White SJ, Masters JRW, Woolf AS. Chapter 4. Renal and bladder epithelial cells. In Handbook
in Practical Animal Cell Biology: Epithelial Cell Culture. Ed Harris A. Cambridge University Press,
Cambridge, UK. 58-78, 1996.
3. Woolf AS. The biology of kidney malformations. In Embryos, Genes and Birth Defects. Ed.
Thorogood P. John Wiley and Sons Ltd, London, UK. 303-327, 1997.
4. Woolf AS. Chapter 1. Developmental anatomy and physiology of the kidney. In Investigation
and Management of Inherited Disorders of the Kidney. Eds. Morgan SH and Grunfeld J-P. Oxford
University Press, Oxford, UK. 3-20, 1998.
5. Woolf AS. Chapter 50. The single kidney. In Pediatric Surgery and Urology: Long-Term
Outcomes. Eds. Stringer MD, Mouriquand PDE, Oldham KT, Howard ER. WB Saunders
Company Ltd, London, UK. 625-631, 1998.
6. Risdon RA, Woolf AS. Chapter 2. Development of the kidney. In Heptinstall's Pathology of the
Kidney. 5th edition. Eds Jennette JC, Olson JL, Schwartz MM, Silva FG. Lippincott-Raven,
Philadelphia-New York, USA. 67-84, 1998.
7. Risdon RA, Woolf AS. Chapter 26. Developmental defects and cystic diseases of the kidney.
In Heptinstall's Pathology of the Kidney. 5th edition. Eds Jennette JC, Olson JL, Schwartz MM,
Silva FG. Lippincott-Raven, Philadelphia-New York, USA. 1149-1206, 1998.
8. Woolf AS. Chapter 1: Embryology of the kidney. In Pediatric Nephrology 4th Edition. Eds
Barratt TM, Avner A, Harmon W. Williams and Wilkins, Baltimore, USA. 1-19, 1999.
9. Woolf AS. Primary vesicoureteric reflux and associated nephropathies. In Horizons in Medicine
11. Ed. Pusey C. Royal College of Physicians of London, UK. 325-333, 1999.
10. Woolf AS. Chapter 15. Genes, urinary tract development and human disease. In Pediatric
Urology. Eds Gearhart JP, Rink RC, Mouriquand PDE. WB Saunders Company. 225-236, 2001.
11. Woolf AS, Yuan HT. Chapter 17. The development of kidney blood vessels. In The Kidney:
from Normal Development to Congenital Disease. Vize PD, Woolf AS, Bard JBL. Elsevier
Science/Academic Press, 251-266, 2003.
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13. Woolf AS. Chapter 28. Congenital kidney diseases: prospects for new therapies. In The
Kidney: from Normal Development to Congenital Disease. Eds Vize PD, Woolf AS, Bard JBL.
Elsevier Science/Academic Press, 487-492, 2003.
12B. PUBLICATIONS – CHAPTERS IN BOOKS (continued)
14. Woolf AS. Anomalies du developpement et mechanisms des malformations du rein et de
l‟appareil urinaire (When kidney development goes wrong: mechanisms of malformations). In
Actualites Nephrologiques Jean Hamburger/Hopital Necker. Medecine-Sciences, Flammarion,
Paris. 23-30, 2003
15. Woolf AS. Kidney and lower urinary tract malformations. In Oxford Monographs on Medical
Genetics 48: The Genetics of Renal Disease. Eds Flinter F, Maher E, Saggar-Malik A. Oxford
University Press, Oxford, UK. 89-115, 2003.
16. Woolf AS. Chapter 1: Embryology. In Pediatric Nephrology 5th Edition. Eds Avner ED,
Harmon WE, Niaudet P. Williams and Wilkins, Baltimore, USA. 3-24, 2004.
17. Woolf AS, Jenkins D. Chapter 2. Development of the kidney. In Heptinstall's Pathology of the
Kidney. 6th edition. Eds Jennette JC, Olson JL, Schwartz MM, Silva FG. Lippincott-Raven,
Philadelphia-New York, USA. 71-95, 2006.
18. Woolf AS. Chapter 53. The single kidney. In Pediatric Surgery and Urology: Long-Term
Outcomes. Eds. Stringer MD, Mouriquand PDE, Oldham KT. Cambridge University Press,
Cambridge, UK. 675-682, 2006.
19. Woolf AS, Pitera JE. Chapter 1: Embryology. In Pediatric Nephrology 6th Edition. Eds Avner
ED, Harmon WE, Niaudet P, Yoshikawa N. Springer. 3-30, 2009.
20. Woolf AS. Chapter 12. Genes, urinary tract development and human disease. In Pediatric
Urology. 2 nd Edition. Eds Gearhart JP, Rink RC, Mouriquand PDE. Elsevier, Philadelphia, PA,
US. 172-179, 2010.
21. Stuart HM, Woolf AS. Genetics of renal tract malformations. In Progress in Paediatric
Urology. Clinical Research: Current and Potential Applications. In press.
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12C. PUBLICATIONS – ORIGINAL RESEARCH ARTICLES
1. Boyland E, Woolf AS. Effect of thiocyanate on nitrite estimation and the cleavage of
nitrosamines. IARC Sci Publ 161-171, 1976.
2. Tung KT, Woolf A, Falzon M. Prostatic involvement in Wegeners granulomatosis. Postgrad
Med J 63:53-54, 1987.
3. Woolf AS, Conway G. Systemic lupus erythematosus and primary cerebral lymphoma.
Postgrad Med J 63:569-571, 1987.
4. Rode J, Dillon AP, Cotton PB, Woolf A, O'Riordan JLH. Carcinoid tumour of the stomach and
primary hyperparathyroidism. J Clin Pathol 40:546-551, 1987.
5. Woolf AS, Moult PJA. Plasma levels of atrial natriuretic peptide in hyperthyroidism. Clin
Endocrinol 27:721-725, 1987.
6. Woolf AS, Moult PJA. Plasma levels of atrial natriuretic peptide in hypothyroidism. Brit Med J
296:531, 1988.
7. Woolf AS, Simpson KL, Mansell MA, Moult PJA. The effect of renal transplantation on plasma
levels of atrial natriuretic factor. Nephrol Dial Transplant 2:205-209, 1988.
8. Woolf AS, Street PR, Walmsley K, Cohen SL. Portal vein thrombosis in the nephrotic
syndrome. Nephrol Dial Transplant 4:581-582, 1989.
9. Woolf AS. MD Thesis. Atrial Natriuretic Factor and Chronic Renal Disease. University of
London. 1-290, 1989.
10. Woolf AS, Cohen SL, Hoffbrand BI, Mansell MA, Moult PJA. The effects of low dose
intravenous 99-126 atrial natriuretic peptide infusion in patients with chronic renal failure.
Postgrad Med J 65:362-366, 1989.
11. Woolf AS, Lyon TL, Cohen SL, Hoffbrand B, Moult PJA. Effects of physiological infusion of
atrial natriuretic factor on healthy subjects and patients with nephrotic syndrome. Nephron
54:244-250, 1989.
12. Woolf AS. Does atrial natriuretic factor contribute to the progression of renal disease? Med
Hypotheses 31:261-263, 1990.
13. Woolf AS, Palmer SJ, Snow ML, Fine LG. Creation of a functioning chimeric mammalian
kidney. Kidney Int 38:991-997, 1990.
14. Woolf AS, Hornbruch A, Fine LG. Integration of new embryonic nephrons into the kidney. Am
J Kid Dis 17:611-614, 1991.
15. Woolf AS, Bosch RJ, Fine LG. Gene transfer into the mammalian kidney: microtransplantation
of retrovirus-transduced metanephric tissue. Exp Nephrol 1:41-48, 1993.
16. Bosch RJ, Woolf AS, Fine LG. Gene transfer into the mammalian kidney: direct retrovirus
transduction of regenerating tubular epithelial cells. Exp Nephrol 1:49-54, 1993.
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17. Hardman P, Landels E, Woolf AS, Spooner BS. Transforming growth factor-�1 inhibits
growth and branching morphogenesis in embryonic mouse submandibular and sublingual glands.
Dev Growth Differ 36:567-577, 1994.
12C. PUBLICATIONS - ORIGINAL RESEARCH ARTICLES (continued)
18. Woo DDL, Miao S, Pelayo J, Woolf AS. Taxol inhibits progression of congenital polycystic
kidney disease. Nature 368:750-753, 1994.
19. Barber RD, Woolf AS, Henderson RM. A characterisation of the chloride conductance in
mesangial cells from the H-2K b -tsA58 transgenic mouse. Biochim Biophys Acta 1269:267-274,
1995.
20. Woolf AS, Kolatsi-Joannou M, Hardman P, Andermarcher E, Moorby C, Fine LG, Jat PS,
Noble MD, Gherardi E. Roles of hepatocyte growth factor/scatter factor and the met receptor in
the early development of the metanephros. J Cell Biol 128:171-184, 1995.
21. Kolatsi-Joannou M, Woolf AS, Hardman P, Gordge M, White S, Henderson R. The
hepatocyte growth factor/scatter factor receptor, met, transduces a morphogenetic signal in renal
glomerular fibromuscular mesangial cells. J Cell Sci 108:3703-3714, 1995.
22. Duke V, Winyard PJD, Thorogood PV, Soothill P, Bouloux PMG, Woolf AS. KAL, a gene
mutated in Kallmann's syndrome, is expressed in the first trimester of human development. Mol
Cell Endocrinol 110:73-79, 1995.
23. Winyard PJD, Nauta J, Lirenman DS, Hardman P, Sams VR, Risdon AR, Woolf AS.
Deregulation of cell survival in cystic and dysplastic renal development. Kidney Int 49:135-146,
1996.
24. Winyard PJD, Risdon RA, Sams VR, Dressler GR, Woolf AS. The PAX2 transcription factor is
expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. J
Clin Invest 98:451-459, 1996.
25. Winyard PJD, Bao Q, Hughes RC, Woolf AS. Epithelial galectin-3 during human
nephrogenesis and childhood cystic diseases. J Am Soc Nephrol 8:1647-1657, 1997.
26. Barber RD, Woolf AS, Henderson RM. Proliferative state affects potassium conductances in
conditionally-immortal renal glomerular mesangial cells. Biochim Biophys Acta 1355:191-203,
1997.
27. Kolatsi-Joannou M, Moore R, Winyard PJD, Woolf AS. Expression of hepatocyte growth
factor/scatter factor and its receptor, MET, suggests roles in human embryonic organogenesis.
Pediatr Res 41:657-665, 1997.
28. Feather SA, Woolf AS, Malcolm S, Donnai D, Winter R. The oral-facial-digital syndrome type
1, a cause of polycystic kidney disease and associated malformations, maps to Xp22.2-22.3.
Hum Mol Genet 6:1163-1167, 1997.
29. Feather SA, Winyard PJD, Dodd S, Woolf AS. Oral-facial-digital syndrome type 1 is another
dominant polycystic kidney disease: clinical, radiological and histopathological features of a new
kindred. Nephrol Dial Transplant 12:1354-1361, 1997.
30. Loughna S, Hardman P, Landels E, Jussila L, Alitalo K, Woolf AS. A molecular and genetic
analysis of renal glomerular capillary development. Angiogenesis 1:84-101, 1997.
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31. Loughna S, Yuan HT, Woolf AS. Effects of oxygen on vascular patterning in Tie1/LacZ
metanephric kidneys in vitro. Biochem Biophys Res Commun 247:361-366, 1998.
12C. PUBLICATIONS - ORIGINAL RESEARCH ARTICLES (continued)
32. Duke V, Quinton R, Gordon I, PMG Bouloux, Woolf AS. Proteinuria, hypertension and chronic
renal failure in X-linked Kallmann's syndrome, a defined genetic cause of solitary functioning
kidney. Nephrol Dial Transplant 13:1998-2003, 1998.
33. Towers PR, Woolf AS, Hardman P. Glial cell line-derived neurotrophic factor stimulates
ureteric bud outgrowth and enhances survival of ureteric bud cells in vitro. Exp Nephrol 6:337-
351, 1998.
34. Attar R, Quinn F, Winyard PJD, Mouriquand PDE, Foxall P, Hanson MA, Woolf AS. Shortterm
urinary flow impairment deregulates PAX2 and PCNA expression and cell survival in fetal
sheep kidneys. Am J Pathol 152:1225-1235, 1998.
35. Cale CM, Klein NJ, Morgan G, Woolf AS. Tumour necrosis factor-� inhibits epithelial
differentiation and morphogenesis in the mouse metanephric kidney in vitro. Int J Dev Biol
42:663-674, 1998.
36. Woolf AS. Solitary kidney and bicornuate uterus in mother and child. Nephrol Dial Transplant
14:960-961, 1999.
37. Beales PL, Elcioglu N, Woolf AS, Parker D, Flinter FA. New criteria for improved diagnosis of
Bardet-Biedl syndrome: results of a population survey. J Med Genet 36:437-446, 1999.
38. Leimeister C, Bach A, Woolf AS, Gessler M. Screen for genes regulated during early kidney
morphogenesis. Dev Genet 24:273-283, 1999.
39. Yuan HT, Suri C, Yancopoulos GD, Woolf AS. Expression of angiopoietin-1, angiopoietin-2
and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. J Am Soc Nephrol
10:1722-1736, 1999.
40. Cale CM, Winyard PJD, Klein NJ, Woolf AS. Inflammatory mediators in human renal
dysplasia. Nephrol Dial Transplant 15:173-183, 2000.
41. Feather SA, Malcolm S, Woolf AS, Wright V, Blaydon D, Reid CJD, Flinter FA, Proesmans
W, Devriendt K, Carter J, Warwicker P, Goodship THJ, Goodship JA. Primary, non-syndromic
vesicoureteric reflux and its nephropathy is genetically heterogeneous with a locus on
chromosome 1. Am J Hum Genet 66:1420-1425, 2000.
42. Yuan H-T, Suri C, Landon DN, Yancopoulos GD, Woolf AS. Angiopoietin-2 is a site specific
factor in differentiation of mouse renal vasculature. J Am Soc Nephrol 11:1055-1066, 2000.
43. Yuan HT, Yang SP, Woolf AS. Hypoxia upregulates angiopoietin-2, a Tie-2 ligand, in mouse
mesangial cells. Kidney Int 58:1912-1919, 2000.
44. Yang SP, Woolf AS, Yuan HT, Scott RJ, Risdon RA, O‟Hare MJ, Winyard PJD. Potential
biological role of transforming growth factor �1 in human congenital kidney malformations. Am J
Pathol 157:1633-1647, 2000.
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45. Beales PL, Reid HAS, Griffiths M, Maher ER, Flinter FA, Woolf AS. Renal cancers and
malformations in relatives of patients with Bardet-Biedl syndrome. Nephrol Dial Transplant
15:1977-1985, 2000.
46. Andreu N, Escarceller M, Feather S, Devriendt K, Woolf AS, Estivill X, Sumoy L. PALML, a
novel paralemmin-related gene mapping on human chromosome 1p21. Gene 278:33-40, 2001.
12C. PUBLICATIONS - ORIGINAL RESEARCH ARTICLES (continued)
47. Bingham C, Bulman MP, Ellard S, Allen LIS, Lipkin GW, van‟t Hoff WG, Woolf AS, Rizzoni G,
Novelli G, Nicholls AJ, Hattersley AT. Mutations in the hepatocyte nuclear factor-1�
associated with familial hypoplastic glomerulocystic kidney disease. Am J Hum Genet 68:219-
224, 2001.
48. Bullock SL, Johnson T, Bao Q, Winyard PJD, RC Hughes, Woolf AS. Galectin-3 modulates
ureteric bud branching in organ culture of the developing mouse kidney. J Am Soc Nephrol
12:515-523, 2001.
49. Ferrante MI, Giorgio G, Feather SA, Bulfone A, Wright V, Ghiani M, Selicorni A, Gammaro L,
Scolari F, Woolf AS, Odent S, Le Marec B, Malcolm S, Winter R, Ballabio A, Franco B.
Identification of the gene for oral-facial-digital type I syndrome. Am J Hum Genet 68:569-576,
2001.
50. Smellie J, Barratt TM, Chantler C, Gordon I, Prescod NP, Ransley PG, Woolf AS. Medical
versus surgical treatment in children with severe bilateral vesicoureteric reflux and bilateral
nephropathy: a randomised trial. The Lancet, 357:1329-1333, 2001.
51. Deeb A, Robertson A, MacColl G, Bouloux PM, Gibson M, Winyard PJD, Woolf AS, Moghal
NE, Cheetham TD. Multicystic kidney and X-linked Kallmann‟s syndrome: a new association?
Nephrol Dial Transplant 16:1170-1175, 2001.
52. Coward RJM, Risdon AR, Bingham C, Hattersley AT, Woolf AS. Kidney disease in
hypomelanosis of Ito. Nephrol Dial Transplant 16:1267-1269, 2001.
53. Yang SP, Woolf AS, Quinn F, Winyard PJD. Deregulation of renal transforming growth factor-
�1 after experimental short-term ureteric obstruction in fetal sheep. Am J Pathol 159:109-117,
2001.
54. Pillebout E, Burtin M, Yuan HT, Briand P, Woolf AS, Friedlander G, Terzi F. Proliferation and
remodeling of the peritubular microcirculation after nephron reduction. Association with the
progression of renal lesions. Am J Pathol 159:547-560, 2001.
55. Kolatsi-Joannou M, Li X, Suda T, Yuan HT, Woolf AS. Expression and potential role of
angiopoietins and Tie-2 in early development of the mouse metanephros. Dev Dyn 222:120-126,
2001.
56. Kolatsi-Joannou M, Bingham C, Ellard S, Bulman MP, Allen LIS, Hattersley AT, Woolf AS.
Hepatocyte nuclear factor 1�: a new kindred with renal cysts and diabetes, and gene expression
in normal human development. J Am Soc Nephrol 12:2175-2180, 2001.
57. Long DA, Woolf AS, Suda T, Yuan HT. Increased renal angiopoietin-1 expression in folic
acid-induced nephrotoxicity in mice. J Am Soc Nephrol 12:2721-2731, 2001.
58. Pitera JE, Smith VV, Woolf AS, Milla PJ. Embryonic gut anomalies in a mouse model of
retinoic acid-induced caudal regression syndrome. Delayed gut looping, rudimentary cecum and
anorectal anomalies. Am J Pathol 159:2321-2329, 2001.
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59. Hillman KA, Johnson TM, Winyard PJD, Burnstock G, Unwin RJ, Woolf AS. P2X7 receptors
are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse.
Exp Nephrol 10:34-42, 2002.
12C. PUBLICATIONS - ORIGINAL RESEARCH ARTICLES (continued)
60. Smeulders N, Woolf AS, Wilcox DT. Smooth muscle differentiation and cell turnover in mouse
detrusor development. J Urol 167:385-390, 2002.
61. Welham SJM, Wade A, Woolf AS. Protein restriction in pregnancy is associated with
increased apoptosis of mesenchymal cells at the start of rat metanephrogenesis. Kidney Int
61:1231-1242, 2002.
62. Yuan HT, Tipping PG, Li XZ, Long DA, Woolf AS. Angiopoietin correlates with glomerular
capillary loss in anti-glomerular basement membrane glomerulonephritis. Kidney Int 61:2078-
2089, 2002.
64. Haq MR, Kalatzis V, Gubler M-C, Town MM, van‟t Hoff WG, Antignac C, Woolf AS. Immunolocaization
of cystinosin, the protein defective in cystinosis. J Am Soc Nephrol 13:2046-2051,
2002.
65. Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJD, Peebles DM, Woolf AS,
Cuckow PM. Effects of in utero bladder outflow obstruction on fetal sheep detrusor contractility,
compliance and innervation. J Urol 168:1615-1620, 2002.
66. Waller SC, Rees L, Woolf AS, Ellard S, Pearson ER, Hattersley AT, Bingham C. Severe
hyperglycemia after renal transplantation in a pediatric patient with mutation of the hepatocyte
nuclear factor 1� gene. Am J Kidney Dis 40:1325-1330, 2002.
67. Smeulders N, Woolf AS, Wilcox DT. Extracellular matrix protein expression during mouse
detrusor development. J Pediatr Surg 38:1-12, 2003.
68. Romio R, Wright V, Price K, Winyard PJD, Donnai D, Porteous ME, Franco B, Giorgio G,
Malcolm S, Woolf AS, Feather SA. OFD1, the gene mutated in oral-facial-digital syndrome type
1, is expressed in the metanephros and in human embryonic renal mesenchymal cells. J Am Soc
Nephrol 14:680-689, 2003.
69. Gordon I, Barkovics M, Pindoria S, Cole TJ, Woolf AS. Primary vesicoureteric reflux as a
predictor of renal damage in children hospitalized with urinary tract infection: a systematic review
and meta-analysis. J Am Soc Nephrol 14:739-744, 2003.
70. Thiruchelvam N, Nyirady P, Peebles DM, Fry CH, Cuckow PM, Woolf AS. Urinary outflow
obstruction increases apoptosis and degregulates Bcl-2 and Bax expression in the fetal ovine
bladder. Am J Pathol 162:1271-1282, 2003.
71. Thiruchelvam N, Wu C, David A, Woolf AS, Cuckow PM, Fry CH. Neurotransmission and
viscoelasticity in the ovine fetal bladder after in utero bladder outflow obstruction. Am J Physiol
Regul Integr Comp Physiol 284:R1296-R1305, 2003.
72. McGregor L, Makela V, Darling SM, Vrontou S, Chalepakis G, Roberts C, Smart N, Rutland
P, Prescott N, Hopkins J, Bentley E, Shaw A, Roberts E, Mueller R, Jadeja S, Philip N, Nelson J,
Francannet C, Perez-Aytes A, Megarbane A, Kerr B, Wainwright B, Woolf AS, Winter RM,
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Scambler PJ. Fraser syndrome and mouse blebbed phenotype caused by mutations in
FRAS1/Fras1 encoding a putative extracellular matrix protein. Nature Genet 34:203-208, 2003.
73. Yuan HT, Li XZ, Pitera JE, Long DA, Woolf AS. Peritubular capillary loss following mouse
acute nephrotoxicity correlates with downregulation of vascular endothelial growth factor-A and
hypoxia-inducible factor-1� Am J Pathol 163:2289-2301, 2003.
12C. PUBLICATIONS - ORIGINAL RESEARCH ARTICLES (continued)
74. Hillman KA, Woolf AS, Johnson T, Wade A, Unwin RJ, Winyard PD. The P2X7 ATP
receptor modulates renal cyst development in vitro. Biochem Biophys Res Commun 322:434-
439, 2004.
75. Jiang S, Gitlin J, Deng F, Liang FX, Atala A, Bauer SB, Ehrlich GD, Feather SA, Goldberg JD,
Goodship JA, Goodship THJ, Hermanns M, Jones KE, Malcolm S, Mendelsohn C, Preston RA,
Retnik AB, Schneck FX, Wright V, Ye XY, Woolf AS, Wu XR, Ostrer H, Shapiro E, Yu J, Sun TT.
Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for
disease heterogeneity. Kidney Int 66:10-19, 2004.
76. Romio L, Fry AM, Winyard PJD, Malcolm S, Woolf AS, Feather SA. OFD1 is a
centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human
nephrogenesis J Am Soc Nephrol 15:2556-2568, 2004.
77. Pitera JE, Woolf AS, Gale NW, Yancopoulos GD, Yuan HT. Dysmorphogenesis of kidney
cortical peritubular capillaries in angiopoietin-2 deficient mice. Am J Pathol 165:1895-1906, 2004.
78. Tse HK, Leung MB, Woolf AS, Menke AL, Hastie ND, Gosling JA, Pang CP, Shum AS.
Implication of Wt1 in the pathogenesis of nephrogenic failure in a mouse model of retinoic acidinduced
caudal regression syndrome. Am J Pathol 166:1295-1307, 2005.
79. Jadeja S, Smyth I Pitera JE, Taylor MS, van Haelst M, Bentley E, McGregor L, Hopkins J,
Chalepakis G, Philip N, Perez-Aytes A, Watt FM, Darling SM, Jackson I, Woolf AS, Scambler
PJ. Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs.
Nature Genet 37:520-525, 2005.
80. Welham SJM, Riley PR, Wade A, Hubank M, Woolf AS. Maternal diet programs embryonic
kidney gene expression. Physiol Genomics 22:48-56, 2005.
81. Jenkins D, Bitner-Glindzicz M, Malcolm S, Allison J, Hu CC, Winyard PJ, Gullett AM, Thomas
DF, Belk RA, Feather SA, Sun TT, Woolf AS. De novo Uroplakin IIIa mutations cause renal
adysplasia leading to severe kidney failure. J Am Soc Nephrol 16:2141-2149, 2005.
82. Burgu B, McCarthy LS, Long DA, Shah V, Wilcox DT, Woolf AS. Vascular endothelial growth
factor stimulates embryonic urinary bladder development in organ culture. BJU Int 98:217-226,
2006.
83. Farrugia MK, Long DA, Godley ML, Peebles DM, Fry CH, Cuckow PM, Woolf AS.
Experimental short-term fetal bladder outflow obstruction. I. Morphology and cell biology
associated with urinary flow impairment. J Pediatr Urol 2:243-253, 2006.
84. Farrugia MK, Godley ML, Woolf AS, Peebles DM, Cuckow PM, Fry CH. Experimental shortterm
fetal bladder outflow obstruction. II. Compliance and contractility associated with urinary
flow impairment. J Pediatr Urol 2:254-260, 2006.
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85. Long DA, Mu W, Price KL, Roncal C, Schreiner GF, Woolf AS, Johnson RJ. Vascular
endothelial growth factor administration does not improve microvascular disease in the saltdependent
phase of post-angiotensin II hypertension. Am J Physiol Renal Physiol 291:F1298-
F1254, 2006.
86. Jenkins D, Bitner-Glindzicz M, Malcolm S, Allison J, de Bruyn R, Thomas DFM, Belk RA,
Feather SA, Bingham C, Southgate J, Woolf AS. Mutation analyses of Uroplakin II in children
with renal tract malformations. Nephrol Dial Transplant 21:3415-3421, 2006.
12C. PUBLICATIONS - ORIGINAL RESEARCH ARTICLES (continued)
87. Chiu MG, Johnson TM, Woolf AS, Dahm-Vicker EM, Long DA, Guay-Woodford L, Hillman
KA, Bawumia S, Venner K, Hughes RC, Poirier F, Winyard PJ. Galectin-3 associates with the
primary cilium and modulates cyst growth in congenital polycystic kidney disease. Am J
Pathology 169:1925-1938, 2006.
88. Kerecuk L, Sajoo A, McGregor L, Berg J, Haq MR, Sebire NJ, Bingham C, Edghill EL, Ellard
S, Taylor J, Rigden S, Flinter FA, Woolf AS. Autosomal dominant inheritance of non-syndromic
renal hypoplasia and dysplasia: dramatic variation in clinical severity in a single kindred. Nephrol
Dial Transplant 22:259-263, 2007.
89. Wu C, Thiruchelvam N, Sui G, Woolf AS, Cuckow P, Fry CH. Ca (2+) regulation in detrusor
smooth muscle from ovine fetal bladder after in utero bladder outflow obstruction. J Urol
177:776-780, 2007.
90. Price KL, Long DA, Jina N, Liapis H, Hubank M, Woolf AS, Winyard PJ. Microarray
interrogation of human metanephric mesenchymal cells highlights potentially important
molecules in vivo. Physiol Genomics 23:193-202, 2007.
91. Jenkins D, Bitner-Glindzicz M, Thomasson L, Malcolm S, Warne SA, Feather SA, Flanagan
SE, Ellard S, Bingham C, Santos L, Zinn A, Henkemeyer M, Baker LA, Wilcox DT, Woolf AS.
Mutational analyses of UPIIIA, SHH, EFNB2 and HNF1� in persistent cloaca and associated
kidney malformations. J Pediatr Urol 3:2-9, 2007.
92. Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, Kim HG, Fan Y, Xi
J, Li QG, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yan J, Giltay JC, Wijmenga C, de
Jong TP, Feather SA, Woolf AS, Rao Y, Lupski JR, Eccles MR, Quade BJ, Gusella JF, Morton
CC, Maas RL. Disruption of ROBO2 is associated with congenital anomalies of kidney and
urinary tract and confers risk of vesicoureteric reflux. Am J Hum Genet 80:616-632, 2007.
93. Burgu B, Medina Ortiz WE, Pitera JE, Woolf AS, Wilcox DT. Vascular endothelial growth
factor mediates hypoxic-stimulated embryonic urinary bladder growth in organ culture. J Urol
177:1552-1557, 2007.
94. Farrugia MK, Woolf AS, Fry CH, Peebles DM, Cuckow PM, Godley ML. Radiotelemetered
urodynamics of obstructed ovine fetal bladders: correlations with ex-vivo cystometry and renal
histopathology. BJU Int 99:1517-1522, 2007.
95. Davis B, Dei Cas A, Long DA, White KE, Hayward A, Ku CH, Woolf AS, Bilous R, Viberti G,
Gnudi L. Podocyte-specific, induced overexpression of angiopoietin-2 causes proteinuria and
apoptosis of glomerular endothelia. J Am Soc Nephrol 18:2320-2329, 2007.
96. Yuan HT, Venkatesha S, Chan B, Deutch U, Mammota T, Sukhatme VP, Woolf AS,
Karumanchi SA. Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated
intracellular signaling and cell survival. FASEB J 21:3171-83, 2007.
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97. Jenkins D, Winyard PJD, Woolf AS. Immunohistochemical analysis of sonic hedgehog
signalling in normal human urinary tract development. J Anat 211:620-629, 2007.
98. Long DA, Price KL, Ioffe E, Gannon CM, Gnudi L, White KE, Yancopoulos GD, Rudge JS,
Woolf AS. Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acidinduced
acute renal injury. Kidney Int 74: 300-309, 2008.
12C. PUBLICATIONS - ORIGINAL RESEARCH ARTICLES (continued)
99. Caubit X, Lye CM, Martin E, Core N, Long DA, Vola C, Jenkins D, Garratt AN, Skaer H,
*Woolf AS, *Fasano L (*joint communicating authors). Teashirt 3 is necessary for ureteral
smooth muscle differentiation downstream of SHH and BMP4. Development 135:3301-3310,
2008.
100. Pitera JE, Scambler PJ, Woolf AS. Fras1, a basement membrane-associated protein
mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the
integrity of renal glomeruli. Hum Mol Genet 17:3953-3964, 2008.
101. Ferrante MI, Romio L, Castro S, Collins JE, Goulding DA, Stemple DL, Woolf AS, Wilson
SW. Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish
orthologue of the human oral-facial-digital type 1 syndrome gene. Hum Mol Genet 18:289-303,
2009.
102. Pastorelli L, Wells S, Fray M, Smith A, Hough T, Harfe BD, McManus MT, Smith L, Woolf
AS, Cheeseman M, Greenfield A. Genetic analyses reveal a requirement for Dicer1 in the
mouse urogenital tract. Mamm Genome 20:140-151, 2009.
103. Price KL, Woolf AS, Long DA. Unravelling the genetic landscape of urinary bladder
development in mice. J Urol 181:2366-2374. 2009.
104. Adalat S, Woolf AS, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC,
Ledermann SE, Rees L, van‟t Hoff W, Marks SD, Trompeter RS, Tullus K, Winyard PJ, Cansick
J, Mushtaq I, Dhillon HK, Bingham C, Edghill EL, Shroff R, Stanescu H, Ryffel G, Ellard S,
Bockenhauer D. Hepatocyte Nuclear Factor 1B mutations associate with hypomagnesemia and
renal magnesium wasting. J Am Soc Nephrol 20:1123-1131, 2009.
105. Jenkins D, Caubit X, Dimovski A, Matevska N, Lye CM, Cabuk F, Gucev Z, Tasic V,
Fasano L, Woolf AS. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction
obstruction. Nephrol Dial Transplant 25:54-60, 2010.
106. Cordell HJ, Darlay R, Charoen P, Stewart A, Gullett AM, Lambert HJ, The UK VUR Study
Group, Malcolm S, Feather SA, Goodship THJ, Woolf AS, Kenda RB, Goodship JA. Wholegenome
linkage and association scan in primary, non-syndromic vesicoureteric reflux. J Am Soc
Nephrol 21:113-123; 2010.
107. Chan S-K, Riley PR, Price KL, McElduff F, Winyard PJ, Welham SJ, Woolf AS, Long DA.
Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of
known cystogenic molecules, as well as indian hedgehog. Am J Physiol Renal Physiol
289:F346-F356, 2010.
108. Daly SB, Urquhart JE, Hilton E, McKenzie EA, Kammerer RA, Lewis M, Kerr B, Stuart H,
Donnai D, Long DA, Burgu B, Aydogdu O, Derbent M, Garcia-Minaur S, Reardon W, Gener B,
Shalev S, Smith R, Woolf AS, Black GC, Newman WG. Mutations in HPSE2 cause urofacial
syndrome. Am J Hum Genet 11:963-969, 2010.
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109. Mekahli D, Woolf AS, Bockenhauer D. Similar renal outcomes in children with ADPKD
diagnosed by screening or presenting with symptoms. Pediatr Nephrol 11:2275-2282, 2010.
110. Yates LY, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH.
The planar cell polarity gene Vangl2 is required for mammalian kidney branching
morphogenesis and glomerular maturation. Hum Mol Genet 19:4663-4676, 2010.
12C. PUBLICATIONS - ORIGINAL RESEARCH ARTICLES (continued)
111. Lopes CAM, Prosser SL, Romio L, Hirst RA, O'Callaghan C, Woolf AS, Fry AM. Centriolar
satellites are assembly points for proteins implicated in human ciliopathies including oral-facialdigital
syndrome 1. J Cell Sci 124:600-612, 2011.
112. Lambert HJ, Stewart A, Gullett AM, Cordell HJ, Malcolm S, Feather SA, Goodship JA,
Goodship THJ, Woolf AS; on behalf of the UK VUR Study Group. Primary, non-syndromic
vesicoureteric reflux and nephropathy in sibling pairs: a United Kingdom cohort for a DNA bank.
Clin J Am Soc Nephrol 6:760-766, 2011.
113. Renal FMD may not confer a familial hypertensive risk nor is it caused by ACTA2
mutations. Marks SD, Gullett AM, Brennan E, Tullus K, Jaureguiberry G, Klootwijk E, Stanescu
HC, Kleta R, Woolf AS. Pediatr Nephrol epub ahead of print DOI: 10.1007/s00467-011-1891-0
12D. PUBLICATIONS - RESEARCH LETTERS
1. Woolf AS, Moult PJA, Sutters M, Mansell MA. Physiological release of atrial natriuretic peptide
in a heart transplant recipient. Lancet 2:213, 1987.
2. Withers DJ, Woolf AS, Kingswood JC, Tsang WN, Mansell MA. Encephalopathy in patient
taking aluminium-containing agents, including sucralfate. Lancet 2:674, 1989.
3. Oram RA, Edghill EL, Woolf AS, Hennekam RC, Ellard S, Hattersley AT, Bingham C. RET
gene mutations are not a common cause of congenital solitary functioning kidney in adults. NDT
Plus 2:183-184, 2009.
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12E. PUBLICATIONS – REVIEWS, TEACHING ARTICLES AND EDITORIALS
1. Woolf AS. Atrial natriuretic peptide and renal disease. Nephrol Dial Transplant 4:1008-1015,
1989.
2. Woolf AS, Fine LG. Retarding the progression of renal diseases. J Nephrol 4:255-267, 1991.
3. Woolf AS, Fine LG. Do glomerular hemodynamic adaptations influence the progression of
human renal disease? Pediatr Nephrol 5:88-93, 1991.
4. Fine LG, Woolf AS, Gallego C. Of rats and men: the need for more convincing studies on
progression of renal diseases. Am J Kidney Dis 18:258-260, 1991.
5. Woolf AS, Bosch RJ, Fine LG. Growth factors in the pathogenesis of renovascular
complications of diabetes mellitus. J Hypertens 10:S11-S16, 1992.
6. Woolf AS, Frischauf A-M, Shaw DG, McCartney SA, Clarkson P. Autosomal dominant
polycystic kidney disease. Lancet 339:1146-1149, 1992.
7. Bard JBD, Woolf AS. Nephrogenesis and the development of renal disease. Nephrol Dial
Transplant 7:563-572, 1992.
8. Prichard BNC, Owens CWI, Woolf AS. Adverse reations to diuretics. Eur Heart J 13:suppl
G96-103, 1993.
9. Woolf AS, Fine LG. Genetically engineered kidneys. Pediatr Nephrol 7:605-608, 1993.
10. Woolf AS, Bosch RJ, Fine LG. Gene transfer into the mammalian kidney. Kidney Int 43:S116-
S119, 1993.
11. Hardman P, Kolatsi M, Winyard PJD, Towers PR, Woolf AS. Branching out with the ureteric
bud. Exp Nephrol 2:211-219, 1994.
12. Woolf AS. Cures for polycystic kidney diseases? Nephrol Dial Transplant 9:1361-1362, 1994.
13. Woolf AS, Winyard PJD. Unravelling the pathogenesis of cystic kidney diseases. Arch Dis
Child 72:103-105, 1995.
14. Woolf AS. Clinical impact and biological basis of kidney malformations. Sem Nephrol 15:361-
372,1995.
15. Loughna S, Landels EC, Woolf AS. Growth factor control of developing kidney endothelial
cells. Exp Nephrol 4:112-118, 1996.
16. Feather SA, Woolf AS, Gordon I, Risdon RA, Verrier-Jones K. Vesicoureteric reflux – all in
the genes? Lancet 348:725-728, 1996.
17. Woolf AS. Genetic manipulation of the embryonic kidney. Exp Nephrol 5:152-156, 1997.
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18. Woolf AS, Cale CM. Roles of growth factors in renal development. Curr Opin Nephrol
Hypertens 6:10-14, 1997.
19. Woolf AS. Molecular bases of human kidney malformations. Pediatr Nephrol 11:373-376,
1997.
12E. PUBLICATIONS – REVIEWS, TEACHING ARTICLES AND EDITORIALS (continued)
20. Woolf AS. Multiple causes of human renal malformations. Arch Dis Child 77:471-473, 1997.
21. Woolf AS. Molecular control of nephrogenesis and the pathogenesis of kidney malformations.
Brit J Urol 81 (suppl 2):1-7, 1998.
22. Woolf AS, Winyard PJD. Advances in the cell biology and genetics of human kidney
malformations. J Am Soc Nephrol 9:1114-125, 1998.
23. Woolf AS, Loughna S. Origin of glomerular capillaries – is the verdict in? Exp Nephrol 6:17-
21, 1998.
24. Woolf AS. Emerging roles of obstruction and mutations in renal malformations. Pediatr
Nephrol 12:690-694, 1998.
25. Dressler GR, Woolf AS. PAX2 in development and renal disease. Int J Dev Biol 43:463-468,
1999.
26. Woolf AS, Beales PL, Feather SA. Human malformation syndromes: lessons in kidney
differentiation. Adv Nephrol Necker Hosp 29:329-339, 1999.
27. Woolf AS, Winyard PJD. Gene expression and cell turnover in human renal dysplasia. Histol
Histopathol 15:159-166, 2000.
28. Woolf AS. Diabetes, genes and kidney development. Kidney Int 57:1202-1203, 2000.
29. Woolf AS. A molecular and genetic view on human kidney and urinary tract malformations.
Kidney Int 58:500-512, 2000.
30. Woolf AS. The life of the human kidney before birth: its secrets unfold. Pediatr Res 49:8-10,
2001.
31. Woolf AS, Yuan HT. Angiopoietin growth factors and Tie receptor tyrosine kinases in renal
vascular development. Pediatr Nephrol 16:177-184, 2001.
32. Woolf AS, Thiruchelvam N. Congenital obstructive uropathy – its origin and contribution to
end-stage renal failure in children. Adv Ren Replace Ther 8:157-163, 2001.
33. Woolf AS, Winyard PJD. Molecular mechanisms of human embryogenesis: developmental
pathogenesis of renal tract malformations. Pediatr Dev Pathol 8:108-129, 2002.
34. Woolf AS, Bingham C, Feather SA. Recent insights into kidney diseases associated with
glomerular cysts. Pediatr Nephrol 17:229-235, 2002.
35. Woolf AS, Welham SJM. Cell turnover in normal and abnormal kidney development. Nephrol
Dial Transplant 17 (Suppl 9):2-4, 2002.
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36. Woolf AS. Congenital obstructive nephropathy gets complicated. Kidney Int 63:761-763,
2003.
37. Welham SJM, Woolf AS. Organ culture of intact metanephric kidneys. Methods Mol Med
86:169-177, 2003.
12E. PUBLICATIONS – REVIEWS, TEACHING ARTICLES AND EDITORIALS (continued)
38. Woolf AS, Price K, Scambler PJ, Winyard PJD. Evolving concepts in human renal dysplasia.
J Am Soc Nephrol 15:998-1007, 2004.
39. Woolf AS. Do kidney tubules serve an angiogenic soup? Kidney Int 66:862-863, 2004.
40. Woolf AS, Wilcox DT. Understanding primary vesicoureteric reflux and associated
nephropathies. Curr Paediatr 14:563-567, 2004.
41. Woolf AS. Molecular and genetic analyses of renal capillary development: studying the
angiopoietin/Tie axis. Kidney Int 68:1968, 2005.
42. Woolf AS. Unilateral multicystic dysplastic kidney. Kidney Int 69:190-193, 2006.
43. Woolf AS. Renal hypoplasia and dysplasia: starting to put the jigsaw together. J Am Soc
Nephrol 17: 2647-2649, 2006.
44. Woolf AS, Hillman KA. Unilateral renal agenesis and the congenital solitary functioning
kidney: developmental, genetic and clinical perspectives. BJU Int 99:17-21, 2007.
45. Jenkins D, Woolf AS. Uroplakins: new molecular players in the biology of urinary tract
malformations. Kidney Int 71:195-200, 2007.
46. Woolf AS. Perspectives on human perinatal renal tract disease. Semin Fetal Neonatal Med
13:196-201, 2008.
47. Kerecuk L, Schreuder MF, Woolf AS. Human renal tract malformations: perspectives for
Nephrologists. Nat Clin Pract Nephrol 4:312-325, 2008.
48. Woolf AS, Gnudi L, Long DA. Roles of angiopoietins in kidney development and disease. J
Am Soc Nephrol 20:239-244, 2009.
49. Woolf AS. Angiopoietins: vascular growth factors looking for roles in glomeruli. Curr Opin
Nephrol Hypertens 19:20-25, 2010.
49. Lye CM, Fasano L, Woolf AS. Ureter myogenesis: putting Teashirt into context. J Am Soc
Nephrol 21:24-30, 2010.
50. Farrugia MK, Woolf AS. Congenital urinary bladder outlet obstruction. Fetal and Maternal
Medicine Review 21:155–173, 2010.
51. Adalat S, Bockenhauer D, Ledermann SE, Hennekam RC, Woolf AS. Renal malformations
associated with mutations of developmental genes: messages from the clinic. Pediatr Nephrol
11:2242-2255, 2010.
52. Woolf AS. Environmental influences on renal tract development: a focus on maternal diet and
the glucocorticoid hypothesis. Klin Padiatr Suppl1:S10-S17, 2011.
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