Anisha Patel COSMOS UC Davis Cluster 1: Biotechnology

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‣ is proving to be useful to analyze quickly thefunctions of a number of genes in a wide variety oforganisms‣ RNAi may facilitate drug screening anddevelopment by identifying genes that can providedrug resistance or genes whose mutant phenotypesare relieved by drug treatment‣ can potentially be used as therapeutic reagentsbecause of their power todownregulate the expression patternof mutant genes in diseased cells
Initially had difficulty on designing an effectivesiRNA sequence lack of accuracy was not only because of itsdependence on the chosen siRNA sequence, butalso on the structure of the siRNA Although the siRNAs are fairly stable in culturedenvironments, it is difficult to enhance the siRNAstability in vivo (in life) however, stability of the siRNA is difficult tocome by without compromising target silencing
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Page 27: http://www.pawelmazur.org/blog/?tag

Anisha Patel COSMOS UC Davis Cluster 1: Biotechnology

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