User Guide to Thresholds and Classification - Environmental ...

417User Guide for Thresholds and ClassificationsTable 21B.1: Terrestrial vertebrate toxicity test guidelines for chemicals, including mixturesSpeciesMammalian acuteTest guideline numberOECD EC USEPA OPPTS401: Acute Oral Toxicity * None870.11001420: Acute Oral Toxicity –Fixed Dose ProcedureEC Method B.1 bisNoneAcute oral toxicity423: Acute Oral Toxicity –Acute Toxic Class MethodEC Method B.1 trisNone425: Acute Oral Toxicity – Upand Down ProcedureNoneNoneAcute dermal toxicity 402: Acute Dermal Toxicity EC Method B.3 870.1200Avian acuteAcute oral toxicity None None 850.2100Acute dietary toxicityMammalian chronicRodent sub-chronic oraltoxicityNon-rodent sub-chronicoral toxicityAvian chronic205: Avian Dietary ToxicityTest408: Repeated Dose 90-DayOral Toxicity Study in Rodents409: Repeated Dose 90-DayOral Toxicity Study in Non-RodentsNone 850.2200EC Method B.26 870.3100EC Method B.27 870.3150Reproduction Test 206: Avian Reproduction Test None 850.2300Note* OECD Test Guideline 401 was deleted from the OECD manual of internationally accepted test guidelines on 17December 2002. Acute oral toxicity studies conducted after this date should now adhere to one of the threealternative methods (OECD Codes 420, 423 and 425).Table 21B.2: Terrestrial vertebrate toxicity test guidelines for microbial biopesticidesUSEPA OPPTS guidelines885.0001 Overview for microbial pest control agents885.3050 Acute oral toxicity/pathogenicity885.3100 Acute dermal toxicity/pathology885.3150 Acute pulmonary toxicity/pathogenicityJanuary 2012 EPA0109