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264User Guide for Thresholds and ClassificationsToxicokinetics 417 EC B.36: Toxicokinetics 870.7485Dermal penetration – – 870.7600Immunotoxicity – – 870.7800Note: Data from reproductive or developmental toxicity studies may be used when specific target organ effects arefound in parental animals, particularly when data are sparse from other studies.January 2012 EPA0109
265User Guide for Thresholds and ClassificationsAppendix 17B: Conversion of parts per million in the diet perday to milligrams of the substance per kilogram of bodyweightper dayUse Table 17B.1 to convert data from repeat-dose studies with the substance in the diet per day tomilligrams of the substance per kilogram of bodyweight per day.Table 17B.1: Approximate relation of concentration of the substance in the diet (ppm) to dietary intake (mg/kgbw/day)AnimalWeight (kg)Foodconsumedper day (g)Type of dietOne ppm infood = mg/kgbw/dayOne mg/kgbw/day = ppmof dietMouse 0.02 30.150 7Chick 0.4 50 0.125 8Rat (young) 0.1 10 0.100 10Rat (old) 0.4 20Dry laboratorychow diets0.050 20Guinea pig 0.75 30 0.040 25Rabbit 2.0 60 0.030 33Dog 10.0 250 0.025 40Cat 2 1000.050 20Monkey 5 250Moist, semi-0.050 20Dog 10 750solid diets0.075 13Man 60 1,500 0.025 40Pig or sheep 60 2,4000.040 25Cow500 750 Relatively dry 0.015 65(maintenance)grain forageCow (fattening) 500 15,000mixtures0.030 33Horse 500 10,000 0.200 50Notesa. g = gram; kg = kilogram; mg/kg bw/day = milligrams of the substance per kilogram of bodyweight per day; ppm= parts per million.b. The values in this table are average figures derived from numerous sources.Source: Adapted from IPCS (1990), originally from Lehman (1954).January 2012 EPA0109
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