User Guide to Thresholds and Classification - Environmental ...

263User Guide for Thresholds and ClassificationsTable 17A.1: Specific target organ toxicity (single or repeated exposure) test guidelines for chemicals, includingmixturesTest protocolsTest guidelineOECDECUSEPAOPPTSChronic toxicity 452 EC B.30 Chronic toxicity test 870.4100Combined chronic toxicity andcarcinogenicity453EC B.33 Combined chronic toxicity/carcinogenicitytest870.430090-day oral toxicity 408EC B.26 Subchronic oral toxicity test: repeateddose 90-day study in rodents870.3100Subchronic non-rodent oraltoxicity409EC B.27 Subchronic oral toxicity test: repeateddose 90-day study in non- rodents870.3150Repeated dose oral toxicity –28 daysRepeated dose dermal toxicity– 28 days407 EC B.7 Repeated dose (28 days) toxicity (oral) 870.3050410 EC B.9 870.3200Repeated dose inhalationtoxicity – 28 days412EC B.8 Repeated dose (28 days) toxicity(inhalation)–Subchronic dermal toxicity 411Subchronic inhalation toxicity 413EC B.28 Subchronic dermal toxicity test: 90-dayrepeated dermal dose study using rodent speciesEC B.29 Subchronic inhalation toxicity test: 90-day repeated dermal dose study using rodentspecies870.3250870.3465Delayed neurotoxicity oforganophosphoroussubstances – acute and 28 day418419EC B.37 Delayed neurotoxicity oforganophosphorus substances following acuteexposureEC B.38 Delayed neurotoxicity oforganophosphorus substances 28-day repeateddose study870.6100Neurotoxicity screening battery – – 870.6200Developmental neurotoxicitystudySchedule-controlled operantbehaviour– – 870.6300– – 870.6500Peripheral nerve function – – 870.6850Neurophysiology: sensoryevoked potentials– – 870.6855Companion animal safety – – 870.7200January 2012 EPA0109