User Guide to Thresholds and Classification - Environmental ...

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214User Guide for Thresholds and ClassificationsTable 14A.1: Mutagenicity test guidelines for chemicals, including mixturesTest guideline numberTestOECDECUSEPAOPPTSIn vivo heritable, germ cell mutation testsRodent dominant lethal assay 478Rodent heritable translocation assays 485EC B.22: Rodentdominant lethaltestEC B.25 Mouseheritabletranslocation870.5450870.5460Mouse visible specific locus test – 870.5200Mouse biochemical specific locus test – 870.5195In vivo somatic cell mutation tests:In vivo mammalian cytogenetics tests: Bone marrowchromosomal analysis475EC B.11: In vivoMammalian bonemarrowchromosomeaberration test870.5385In vivo mammalian cytogenetics tests:Erythrocyte/bone marrow micronucleus assay474EC B.12Mammalianerythrocytemicronucleustest870.5395Mouse spot test 484Mutagenicity tests in germ cellsEC B.24: Mousespot test–In vivo mammalian cytogenetics tests:spermatogonial chromosomal aberrations483EC B.23:Mammalianspermatogonialchromosomeaberration test870.5380Genotoxicity tests in germ cellsIn vivo sister chromatid exchange assay – – 870.5915Genotoxicity tests in somatic cellsIn vivo unscheduled DNA synthesis test withmammalian liver cells486 – –In vitro mammalian cell mutagenicity testsDetection of gene mutations in somatic cells in 476 EC B.17: 870.5300January 2012 EPA0109
215User Guide for Thresholds and ClassificationsTestcultureTest guideline numberOECDECMutagenicity – Invitro cell genemutation testUSEPAOPPTSIn vitro mammalian cytogenetics 473In vitro mammalian cell transformation tests –EC B.10:Mutagenicity – Invitro mammalianchromosomeaberration testEC B.21: In vitromammalian celltransformationtest870.5375–Unscheduled DNA synthesis in mammalian cells inculture482EC B.18: DNADamage andrepair –UnscheduledDNA synthesis –Mammalian cellsin vitro870.5550In vitro sister chromatid exchange assay inmammalian cells479EC B.19: Sisterchromatidexchange assayin vitro870.5900In vitro microbial, or insect cell mutation testsEscherichia coli WP2 and WP2 uvrA reversemutation assays472EC B.13:Mutagenicity -Reversemutation testusing bacteria870.5100Gene mutation in Aspergillus nidulans – – 870.5140Gene mutation in Neurospora crassa – – 870.5250Salmonella typhimurium reverse mutation assay 471EC B.14:Mutagenicity -Reversemutation testusing bacteria870.5265Sex-linked recessive lethal test in Drosophilamelanogaster477EC B.20: Sexlinkedrecessivelethal test inDrosophila870.5275January 2012 EPA0109
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