User Guide to Thresholds and Classification - Environmental ...

More documents

Recommendations

Info

204User Guide for Thresholds and ClassificationsTable 13A.1: Respiratory* or contact sensitisation toxicity test guidelines for chemicals, including mixturesTest guideline numberTestOECD EC USEPA OPPTSSkin sensitisation 406EC B.6: Skinsensitisation870.2600Skin sensitisation: Local lymphnode assay429EC B.42: Skinsensitisation: Locallymph node assay870.2600Note* Recognised animal models for the testing of respiratory hypersensitivity are not available. Under certaincircumstances, animal testing may be used, for example, a modification of the guinea pig maximisation test fordetermining the relative allergenicity of proteins. However, these tests still need further validation.January 2012 EPA0109
205User Guide for Thresholds and ClassificationsAppendix 13B: Comparison of Globally Harmonized System ofClassification and Labelling of Chemicals and HSNO Actrespiratory or contact sensitization hazard classification criteriaTable 13B.1 and Table 13B.2 display the eye corrosion/irritation categories from the Globally HarmonizedSystem of Classification and Labelling of Chemicals (United Nations, 2007) and the Hazardous Substancesand New Organisms Act 1996 (HSNO Act) equivalent.Table 13B.1: Comparison of Globally Harmonized System of Classification and Labelling of Chemicals (GHS) andHSNO Act respiratory hazard classification criteriaGHS respiratory sensitisation classification criteriaSubstances are classified as respiratory sensitizers (category 1) if:HSNO Act equivalentcategorya. there is evidence in humans that the substance can induce specific respiratoryhypersensitivity; and/or6.5Ab. there are positive results from an appropriate animal test.Table 13B.2: Comparison of Globally Harmonized System of Classification and Labelling of Chemicals (GHS) andHSNO Act contact sensitization hazard classification criteriaGHS contact sensitisation classification criteriaSubstances are classified as contact sensitizers (category 1) if:HSNO Act equivalentcategoryc. there is evidence in humans that the substance can induce sensitisation byskin contact in a substantial number of people; or6.5Bd. there are positive results from an appropriate animal test.Further details on the GHS classification criteria for respiratory or contact sensitisation are in United Nations(2007, pp 147–150).ReferencesUnited Nations 2007. The Globally Harmonized System of Classification and Labelling of Chemicals (GHS),2nd revised edition. United Nations, Geneva.January 2012 EPA0109
Page 1 and 2:
Thresholds and ClassificationsUnder
Page 3 and 4:
3User Guide for Thresholds and Clas
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
11User Guide for Thresholds and Cla
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21:
Page 24 and 25:
Page 26 and 27:
Page 28 and 29:
Page 30 and 31:
Page 32 and 33:
Page 34 and 35:
Page 36 and 37:
Page 38 and 39:
Page 40 and 41:
Page 42 and 43:
Page 44 and 45:
Page 46 and 47:
Page 48 and 49:
Page 50 and 51:
Page 52 and 53:
Page 54 and 55:
Page 56 and 57:
Page 58 and 59:
Page 60 and 61:
Page 62 and 63:
Page 64 and 65:
Page 66 and 67:
Page 68 and 69:
Page 70 and 71:
Page 72 and 73:
Page 74 and 75:
Page 76 and 77:
Page 78 and 79:
Page 80 and 81:
Page 82 and 83:
Page 84 and 85:
Page 86 and 87:
Page 88 and 89:
Page 90 and 91:
Page 92 and 93:
Page 94 and 95:
Page 96 and 97:
Page 98 and 99:
Page 100 and 101:
100User Guide for Thresholds and Cl
Page 102 and 103:
Page 104 and 105:
Page 106 and 107:
Page 108 and 109:
Page 110 and 111:
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
Page 118 and 119:
Page 120 and 121:
Page 122 and 123:
Page 124 and 125:
Page 126 and 127:
Page 128 and 129:
Page 130 and 131:
Page 132 and 133:
Page 134 and 135:
Page 136 and 137:
Page 138 and 139:
Page 140 and 141:
Page 142 and 143:
Page 144 and 145:
Page 146 and 147:
Page 148 and 149:
Page 150 and 151:
Page 152 and 153:
Page 154 and 155: 154User Guide for Thresholds and Cl
Page 254 and 255:
Page 256 and 257:
Page 258 and 259:
Page 260 and 261:
Page 262 and 263:
Page 264 and 265:
Page 266 and 267:
Page 268 and 269:
Page 270 and 271:
Page 272 and 273:
Page 274 and 275:
Page 276 and 277:
Page 278 and 279:
Page 280 and 281:
Page 282 and 283:
Page 284 and 285:
Page 286 and 287:
Page 288 and 289:
Page 290 and 291:
Page 292 and 293:
Page 294 and 295:
Page 296 and 297:
Page 298 and 299:
Page 300 and 301:
Page 302 and 303:
Page 304 and 305:
Page 306 and 307:
Page 308 and 309:
Page 310 and 311:
Page 312 and 313:
Page 314 and 315:
Page 316 and 317:
Page 318 and 319:
Page 320 and 321:
Page 322 and 323:
Page 324 and 325:
Page 326 and 327:
Page 328 and 329:
Page 330 and 331:
Page 332 and 333:
Page 334 and 335:
Page 336 and 337:
Page 338 and 339:
Page 340 and 341:
Page 342 and 343:
Page 344 and 345:
Page 346 and 347:
Page 348 and 349:
Page 350 and 351:
Page 352 and 353:
Page 354 and 355:
Page 356 and 357:
Page 358 and 359:
Page 360 and 361:
Page 362 and 363:
Page 364 and 365:
Page 366 and 367:
Page 368 and 369:
Page 370 and 371:
Page 372 and 373:
Page 374 and 375:
Page 376 and 377:
Page 378 and 379:
Page 380 and 381:
Page 382 and 383:
Page 384 and 385:
Page 386 and 387:
Page 388 and 389:
Page 390 and 391:
Page 392 and 393:
Page 394 and 395:
Page 396 and 397:
Page 398 and 399:
Page 400 and 401:
Page 402 and 403:
Page 404 and 405:
Page 406 and 407:
Page 408 and 409:
Page 410 and 411:
Page 412 and 413:
Page 414 and 415:
Page 416 and 417:
Page 418 and 419:
Page 420 and 421:
Page 422 and 423:
Page 424 and 425:
Page 426 and 427:
Page 428 and 429:
Page 430 and 431:
Page 432 and 433:
Page 434 and 435:
Page 436 and 437:
Page 438:
BP House, (Level 1), 20 Customhouse
show all

User Guide to Thresholds and Classification - Environmental ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?