User Guide to Thresholds and Classification - Environmental ...

More documents

Recommendations

Info

170User Guide for Thresholds and ClassificationsTable 11A.1: Skin corrosion or irritancy toxicity test guidelines for chemicals, including mixturesTestTest guideline numberOECD EC USEPA OPPTSAcute dermal corrosion or irritation 404EC B.4: Acute toxicity: dermalcorrosion or irritation870.2500In vitro skin corrosion: transcutaneouselectrical resistance test (TER)In vitro skin corrosion: human skinmodel testIn vitro membrane barrier test methodfor skin corrosion430 EC B.40: Skin corrosion (in vitro) –431 EC B.40: Skin corrosion (in vitro) –435 – –January 2012 EPA0109
171User Guide for Thresholds and ClassificationsAppendix 11B: Grading skin reactions and calculating meanDraize scores1. Grading skin reactionsTable 11B.1 displays the grading scores for skin reactions. This is sourced from Organisation for EconomicCo-operation and Development Test Guideline 404.Table 11B.1: Grading scores for skin reactionsScoreDescriptionErythemaOedema0 No erythema No oedema1 Very slight erythema (barely perceptible) Very slight oedema (barely perceptible)2 Well-defined erythemaSlight oedema (edges of area well defined by definiteraising)3 Moderate to severe erythema Moderate oedema (raised approximately 1 mm)4Severe erythema (beet redness) to escharformation preventing grading of erythemaSevere oedema (raised more than 1 mm and extendingbeyond the area of exposure)2. Calculating mean Draize scoresAn example (using substance X) for calculating the mean Draize score is in Table 11B.2.Table 11B.2: Calculating mean Draize scores for erythema and oedema for substance XAnimal number/sexBodyweight (kg) Scoring interval Erythema Oedema1/M2.6341 hour 2 124 hours 2 048 hours 2 072 hours 1 07 days 1 02/M2.7541 hour 2 124 hours 1 048 hours 1 072 hours 0 07 days 0 0January 2012 EPA0109
Page 1 and 2:
Thresholds and ClassificationsUnder
Page 3 and 4:
3User Guide for Thresholds and Clas
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
11User Guide for Thresholds and Cla
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21:
Page 24 and 25:
Page 26 and 27:
Page 28 and 29:
Page 30 and 31:
Page 32 and 33:
Page 34 and 35:
Page 36 and 37:
Page 38 and 39:
Page 40 and 41:
Page 42 and 43:
Page 44 and 45:
Page 46 and 47:
Page 48 and 49:
Page 50 and 51:
Page 52 and 53:
Page 54 and 55:
Page 56 and 57:
Page 58 and 59:
Page 60 and 61:
Page 62 and 63:
Page 64 and 65:
Page 66 and 67:
Page 68 and 69:
Page 70 and 71:
Page 72 and 73:
Page 74 and 75:
Page 76 and 77:
Page 78 and 79:
Page 80 and 81:
Page 82 and 83:
Page 84 and 85:
Page 86 and 87:
Page 88 and 89:
Page 90 and 91:
Page 92 and 93:
Page 94 and 95:
Page 96 and 97:
Page 98 and 99:
Page 100 and 101:
100User Guide for Thresholds and Cl
Page 102 and 103:
Page 104 and 105:
Page 106 and 107:
Page 108 and 109:
Page 110 and 111:
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
Page 118 and 119:
Page 120 and 121: 120User Guide for Thresholds and Cl
Page 220 and 221:
Page 222 and 223:
Page 224 and 225:
Page 226 and 227:
Page 228 and 229:
Page 230 and 231:
Page 232 and 233:
Page 234 and 235:
Page 236 and 237:
Page 238 and 239:
Page 240 and 241:
Page 242 and 243:
Page 244 and 245:
Page 246 and 247:
Page 248 and 249:
Page 250 and 251:
Page 252 and 253:
Page 254 and 255:
Page 256 and 257:
Page 258 and 259:
Page 260 and 261:
Page 262 and 263:
Page 264 and 265:
Page 266 and 267:
Page 268 and 269:
Page 270 and 271:
Page 272 and 273:
Page 274 and 275:
Page 276 and 277:
Page 278 and 279:
Page 280 and 281:
Page 282 and 283:
Page 284 and 285:
Page 286 and 287:
Page 288 and 289:
Page 290 and 291:
Page 292 and 293:
Page 294 and 295:
Page 296 and 297:
Page 298 and 299:
Page 300 and 301:
Page 302 and 303:
Page 304 and 305:
Page 306 and 307:
Page 308 and 309:
Page 310 and 311:
Page 312 and 313:
Page 314 and 315:
Page 316 and 317:
Page 318 and 319:
Page 320 and 321:
Page 322 and 323:
Page 324 and 325:
Page 326 and 327:
Page 328 and 329:
Page 330 and 331:
Page 332 and 333:
Page 334 and 335:
Page 336 and 337:
Page 338 and 339:
Page 340 and 341:
Page 342 and 343:
Page 344 and 345:
Page 346 and 347:
Page 348 and 349:
Page 350 and 351:
Page 352 and 353:
Page 354 and 355:
Page 356 and 357:
Page 358 and 359:
Page 360 and 361:
Page 362 and 363:
Page 364 and 365:
Page 366 and 367:
Page 368 and 369:
Page 370 and 371:
Page 372 and 373:
Page 374 and 375:
Page 376 and 377:
Page 378 and 379:
Page 380 and 381:
Page 382 and 383:
Page 384 and 385:
Page 386 and 387:
Page 388 and 389:
Page 390 and 391:
Page 392 and 393:
Page 394 and 395:
Page 396 and 397:
Page 398 and 399:
Page 400 and 401:
Page 402 and 403:
Page 404 and 405:
Page 406 and 407:
Page 408 and 409:
Page 410 and 411:
Page 412 and 413:
Page 414 and 415:
Page 416 and 417:
Page 418 and 419:
Page 420 and 421:
Page 422 and 423:
Page 424 and 425:
Page 426 and 427:
Page 428 and 429:
Page 430 and 431:
Page 432 and 433:
Page 434 and 435:
Page 436 and 437:
Page 438:
BP House, (Level 1), 20 Customhouse
show all

User Guide to Thresholds and Classification - Environmental ...

Create successful ePaper yourself

Delete template?

Save as template?