User Guide to Thresholds and Classification - Environmental ...

161User Guide for Thresholds and ClassificationsNot irritant or no data1cExisting human or animal experienceNot corrosive orirritantNo further testing, notclassifiedNo data2aStructure-activity relationships orCorrosiveClassify as corrosive aStructure-property relationships bNot corrosive or no data2bStructure activity relationships orIrritantClassify as irritant aStructure-property relationships bNot irritating or no data3 pH with buffering cpH 2 or 11.5 Classify as corrosive aNot pH extreme or no data4 Existing skin data in animals indicate noneed for animal testing dYesPossibly no further testing maybe deemed corrosive or irritantNo indication or no data5 Valid and accepted in vitro skin corrosiontest ePositive responseClassify as corrosive aNegative response or no data6 Valid and accepted in vitroskin irritation test fPositive responseClassify as irritant aNegative response or no data7 In vivo skin corrosion Positive response Classify as corrosive aJanuary 2012 EPA0109