User Guide to Thresholds and Classification - Environmental ...

159User Guide for Thresholds and ClassificationsAcute toxicity results: LD 50 oral, rat: 25 < LD 50 200 mg/kg. Note this cut-offcrosses into6.1C.Harmful (Xn)A substance is determined to be hazardous and classified as Harmful (Xn) and assigned oneor more of the following risk phrases in accordance with the criteria given below.R20 Harmful by inhalationAcute toxicity results:LC 50 inhalation, rat, for aerosols or particulates: 1 < LC 505 mg/L over 4 hours;6.1DLC 50 inhalation, rat, for gases or vapours: 2 < LC 5020 mg/L over 4 hours.R65 Harmful: May cause lung damage if swallowedLiquid substances and preparations presenting an aspiration hazard in humans because oftheir low viscosity:6.1E (aspirationhazard)R21 Harmful in contact with skinAcute toxicity results: LD 50 dermal, rat or rabbit: 400 < LD 50R22 Harmful if swallowedAcute toxicity results:2,000 mg/kg.6.1DLD 50 per oral, rat 200LD 50 < 2,000 mg/kg;6.1Ddiscriminating dose, oral, rat, 50 mg/kg: 100% survival but evident toxicity;less than 100% survival at 500 mg/kg, rat oral by the fixed dose procedureNote: LC 50 = median lethal concentration; LD 50 = median lethal dose; mg/kg = milligrams per kilogram; mg/L =milligrams per litreSource: EC (1967).ReferencesEC 1967. General classification and labelling requirements for dangerous substances and preparations.Council Directive 67/548/EEC of 27 June 1967 on the Approximation of Laws, Regulations andAdministrative Provisions Relating to the Classification, Packaging and Labelling of Dangerous Substances.European Commission, Annex VI. http://ec.europa.eu/environment/dansub/consolidated_en.htm.January 2012 EPA0109