User Guide to Thresholds and Classification - Environmental ...

139User Guide for Thresholds and Classificationsd. A substance for which data indicate an inhalation LC 50 greater than 2.0 mg/L of air but less than orequal to 10 mg/L of air, as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a vapour.e. A substance for which data indicate an inhalation LC 50 greater than 0.5 mg/L of air but less than orequal to 1.0 mg/L of air, as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a dust or mist.Category 6.1Da. A substance for which data indicate an oral LD 50 greater than 300 mg/kg bw but less than or equal to2,000 mg/kg bw, as a result of acute exposure of animals to the substance by the oral route.b. A substance for which data indicate a dermal LD 50 greater than 1,000 mg/kg bw but less than orequal to 2,000 mg/kg bw, as a result of acute exposure of animals to the substance by the dermalroute.c. A substance for which data indicate an inhalation LC 50 greater than 2,500 ppm in air but less than orequal to 5,000 ppm in air as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a gas.d. A substance for which data indicate an inhalation LC 50 greater than 10 mg/L of air but less than orequal to 20 mg/L of air, as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a vapour.e. A substance for which data indicate an inhalation LC 50 greater than 1.0 mg/L of air but less than orequal to 5 mg/L of air, as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a dust or mist.Category 6.1Ea. A substance for which data indicate an LD 50 greater than 2,000 mg/kg bw, but less than or equal to5,000 mg/kg bw, as a result of acute exposure of animals to the substance by oral or dermal routes.b. A substance for which assignment to a more hazardous category is not warranted, and:i. data for the substance indicate to an expert evidence in humans of significant acute toxic effectsas a result of acute exposure to the substance; orii. data indicate any mortality when tested up to category D values by the oral, inhalation, or dermalroutes as a result of acute exposure to the substance; oriii. clinical signs, other than diarrhoea, piloerection, or an ungroomed appearance, indicate to anexpert a significant adverse biological effect when tested up to category D values by the oral,dermal or inhalation routes as a result of acute exposure to the substance; oriv. reliable information, including reliable information from animal studies other than those fromwhich LD50 data were obtained to classify the substance in hazard classification 6.1E, indicatesJanuary 2012 EPA0109