User Guide to Thresholds and Classification - Environmental ...

138User Guide for Thresholds and Classificationsb. A substance for which data indicate a dermal LD 50 less than or equal to 50 mg/kg bw as a result ofacute exposure of animals to the substance by the dermal route.c. A substance for which data indicate an inhalation median lethal concentration (LC50) less than orequal to 100 ppm of the substance in air as a result of acute exposure of animals to the substanceby the inhalation route, where the substance is a gas.d. A substance for which data indicate an inhalation LC50 less than or equal to 0.5 mg of the substanceper litre (mg/L) of air as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a vapour.e. A substance for which data indicate an inhalation LC 50 less than or equal to 0.05 mg/L of air, as aresult of acute exposure of animals to the substance by the inhalation route, where the substance isa dust or mist.Category 6.1Ba. A substance for which data indicate an oral LD 50 greater than 5 mg/kg bw but less than or equal to50 mg/kg bw, as a result of acute exposure of animals to the substance by the oral route.b. A substance for which data indicate a dermal LD 50 greater than 50 mg/kg bw but less than or equalto 200 mg/kg bw, as a result of acute exposure of animals to the substance by the dermal route.c. A substance for which data indicate an inhalation LC 50 greater than 100 ppm in air but less than orequal to 500 ppm in air, as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a gas.d. A substance for which data indicate an inhalation LC 50 greater than 0.5 mg/L of air but less than orequal to 2.0 mg/L of air, as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a vapour.e. A substance for which data indicate an inhalation LC 50 greater than 0.05 mg/L of air but less than orequal to 0.5 mg/L of air, as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a dust or mist.Category 6.1Ca. A substance for which data indicate an oral LD 50 greater than 50 mg/kg bw but less than or equal to300 mg/kg bw, as a result of acute exposure of animals to the substance by the oral route.b. A substance for which data indicate a dermal LD 50 greater than 200 mg/kg bw but less than or equalto 1,000 mg/kg bw, as a result of acute exposure of animals to the substance by the dermal route.c. A substance for which data indicate an inhalation LC 50 greater than 500 ppm in air but less than orequal to 2,500 ppm in air, as a result of acute exposure of animals to the substance by the inhalationroute, where the substance is a gas.January 2012 EPA0109