User Guide to Thresholds and Classification - Environmental ...

133User Guide for Thresholds and ClassificationsTermDefinitionaccording to internationally accepted criteria and scientific practice.See Schedule 4 to the Hazardous Substances (Minimum Degrees of Hazard)Regulations 2001.Includes:a. interference with reproductive ability or capacity, including alteration to themale or female reproductive system; orreproductive effectb. an effect on the onset of puberty, gamete production and transport,reproductive cycle normality, sexual behaviour, fertility, parturition, orpremature reproductive senescence; orc. an effect on or through lactation; ord. modifications in other functions that are dependent on the integrity of thereproductive system.See Schedule 4 to the Hazardous Substances (Minimum Degrees of Hazard)Regulations 2001.respiratory sensitisersensitisationA substance that will induce hypersensitivity of the airways following inhalationof a substance.See United Nations (2007).An immunologically mediated reaction where, after exposure to a substance towhich an organism or a human being has been previously exposed, theorganism or human being is, or one or more organs in an organism or a humanbeing are, more readily and adversely affected by that substance.See Schedule 4 to the Hazardous Substances (Minimum Degrees of Hazard)Regulations 2001.significant adverse biologicaleffectA toxicologically significant change in an organ or animal observed during thestudy where the probability that the change is different from any recognisedbackground history of change or from the value in a recognised unexposedcontrol organ or animal group in the test animal strain is greater than 0.95(equivalent to a probability of 0.05 or less).See Schedule 4 to the Hazardous Substances (Minimum Degrees of Hazard)Regulations 2001.skin corrosionThe production of irreversible damage to the skin; namely, visible necrosisthrough the epidermis and into the dermis, following the application of a testsubstance for up to 4 hours. Corrosive reactions are typified by ulcers, bleeding,bloody scabs, and, by the end of observation at 14 days, by discolouration dueto blanching of the skin, complete areas of alopecia, and scars. Histopathologyshould be considered to evaluate questionable lesions.See United Nations (2007).skin irritationskin sensitiserThe production of reversible damage to the skin following the application of atest substance for up to four hours.See United Nations (2007).A substance that will induce an allergic response following skin contact.January 2012 EPA0109