User Guide to Thresholds and Classification - Environmental ...

132User Guide for Thresholds and ClassificationsTermDefinitiona. from Draize grades measured at intervals of 24 hours, 48 hours, and 72hours after the patch is removed; orb. where reactions are delayed, from Draize grades on three consecutivedays after the onset of dermal reactions.See Schedule 4 to the Hazardous Substances (Minimum Degrees of Hazard)Regulations 2001.mgmLmutagenmilligram(s)millilitre(s)Agents giving rise to an increased occurrence of mutations in populations ofcells and/or organisms.See United Nations (2007).A permanent change in the amount or structure of the genetic material in a cell,being a permanent change that is:mutagenic effecta. manifested at the phenotypic level; orb. an underlying DNA modification (including specific base pair changes andchromosomal translocations).See Schedule 4 to the Hazardous Substances (Minimum Degrees of Hazard)Regulations 2001.oedemaoutlierThe presence of abnormally large amounts of fluid in intercellular spaces ofbody tissues (visible as swelling).See IUPAC (2007).An observation that is numerically distant from the rest of the data.Photosensitisation includes:photosensitisationa. photoirritation, which is a light-induced skin response to a photoreactivechemical; andb. photoallergy, which is an immunologically mediated reaction to a chemicalinitiated by the formation of photoproducts (for example, the photoproductsproduce an antigen).See EMEA (2002).ppmppmVparts per millionparts per million by volumeInformation that is derived from:reliable informationa. a valid and relevant animal study conducted in accordance withinternationally accepted test guidelines and principles of good laboratorypractice; orb. an epidemiological study in humans that is statistically sound and hasundergone peer review; orc. any other study whose relevance and validity can be demonstratedJanuary 2012 EPA0109