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116User Guide for Thresholds and ClassificationsData from internationally harmonised test methods are preferred for classification under each subclass. Datashould preferably be derived using Organisation for Economic Co-operation and Development TestGuidelines or equivalent, according to the principles of Good Laboratory Practice (GLP). When such data arenot available, classification should be based on the best available data using a weight-of-evidence approach.9.4.4. Absence of measured dataThe EPA recognises that measured data may not be available for all hazard endpoints for all substances.The Hazardous Substances (Minimum Degrees of Hazard) Regulations 2001 also acknowledges that:data includes values that are directly measured, calculated, or estimated for any of the measuresgiven.Therefore, while it should be noted that where no measured data are available, classification of a substanceinto a HSNO Act hazard classification category can still occur, using a weight-of-evidence approach thatacknowledges all other data that is available on the substance or closely related substances. If this approachis used, any assumptions made and the weight-of-evidence approach for hazard classification should beclearly documented.If there are no measured (that is, direct) data or indirect data on the substance, the substance cannot beassigned a hazard classification.9.5. Data sourcesThe information sources in Tables 9.1–9.20 (toxicity) and 9.21 (physico-chemical) are provided as a startingpoint only, they are not exhaustive. As noted in section 1.3 in chapter 1, the quality of data is highly variablewithin and between various sources. It is the user‘s responsibility to ensure that the data used forclassification meet the criteria of reliability, relevance, and adequacy.Some of the sources listed in the tables may require a subscription, but most are free.See also Tables 18.1 and 18.2 in chapter 18 below for data sources for ecotoxicity and environmental fate.Table 9.1: Information sources for toxicity – environmental organisations: United StatesInformation sourceURLAgency for Toxic Substances and Disease Registry(ATSDR)American Chemistry Council (ACC)American Industrial Hygiene Association (AIHA)California Office for Environmental Health HazardAssessment (OEHHA)Centers for Disease Control and Prevention(CDC)/Department of Health and Human Services(HHS)http://www.atsdr.cdc.govhttp://www.americanchemistry.com/s_acc/index.asphttp://www.aiha.orghttp://www.oehha.ca.govhttp://www.cdc.govJanuary 2012 EPA0109
117User Guide for Thresholds and ClassificationsNational Cancer Institute (NCI)/National Institutes ofHealth (NIH)National Institute for Occupational Safety and Health(NIOSH)National Toxicology Programme (NTP)/Department ofHealth and Human ServicesUnited States (US) Department of Labor/OccupationalSafety & Health AdministrationUS Department of Transportation/Office of HazardousMaterials SafetyUS Environmental Protection Agency (USEPA)http://www.cancer.govhttp://www.cdc.gov/niosh/homepage.htmlhttp://ntp-server.niehs.nih.govhttp://www.osha.govhttp://hazmat.dot.gov/index.htmlhttp://www.epa.govNote: These URLs may not be the only routes to the information.Table 9.2: Information sources for toxicity – environmental organisations: European UnionInformation sourceURLEuropean Agency for Safety and Health at WorkEuropean Agency for Safety and Health atWork/Dangerous SubstancesEuropean Centre for Ecotoxicology and Toxicology ofChemicals (ECETOC)European Chemical Industry Council (CEFIC)European Chemicals Agency (ECHA)European Environment AgencyEuropean Food Safety Authority (EFSA)European Union (EU) Dangerous Goods (DG) Sanco(health and consumer protection)EU research DGJoint Research Centre (JRC)Scientific Institute of Public Healthhttp://osha.eu.int/OSHAhttp://europe.osha.eu.int/good_practice/risks/dangerous_substanceshttp://www.ecetoc.org/http://www.cefic.orghttp://echa.europa.eu/http://themes.eea.europa.euhttp://www.efsa.europa.eu/http://ec.europa.eu/comm/dgs/health_consumer/index_en.htmhttp://ec.europa.eu/dgs/research/index_en.htmlhttp://irmm.jrc.ec.europa.eu/www.pasteur-international.org/.../scientific-institute-ofpublic-healthNote: These URLs may not be the only routes to the information.Table 9.3: Information sources for toxicity – environmental organisations: InternationalInformation sourceURLConvention for the Protection of the MarineEnvironment of the North-East Atlantic (OSPARhttp://www.ospar.org/January 2012 EPA0109
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