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IC-MS systemA powerful combination: the IC-MS system from Agilent and MetrohmWhy IC-MS?The combination of the two techniques ion chromatography (IC) and mass spectrometry(MS) guarantees improved sensitivity and lower detection limits, as matrixinterference is reduced to the absolute minimum. Thanks to the highly selectivedetection by mass spectrometry, the obtained substance peaks can be identifiedunambiguously. The technique can also be used for the structural analysis of largermolecules. In addition, IC-MS is suitable for element speciation and offers the possibilityof differentiating between organic and inorganic compounds of one and thesame element. Tandem conductivity and mass spectrometric detection provideseven more comprehensive information on the samples to be analyzed.The combined IC-MS system consisting of a Metrohm MIC-2 Advanced IC System with 838 Advanced IC Sample Processor and an Agilent MSD SL mass spectrometer.First system component: Metrohm IC• Automated MIC-2 Advanced IC System• First-class modular ion chromatography system• Easy operation, easy maintenance• 100% solvent-compatible• Large range of separation columns for a wide variety of applications• Full control by Agilent ChemStation software10 Metrohm Information Issue 2/2005
IC-MS systemSecond system component: Agilent MS• 1100 Series MS detector• Single-stage quadrupole mass spectrometer with electrospray ionization (ESI)• Easy operation, easy maintenance• Very robust thanks to orthogonal arrangement of the ion source• Mass range m/z = 2...3000• Multi-signal acquisition in one run, for example SIM + , SIM – , Scan + , Scan –• Eluent flow rate up to 1 mL/min for columns with 2 to 4 mm inner diameterInteresting applicationsWith the IC-MS system from Agilent and Metrohm even complex separation problemscan be solved reliably, fully automatically and with excellent precision. Thespectrum of applications ranges from the determination of 0.1 ppb perchlorate inthe presence of a 10’000’000-fold excess of chloride, carbonate and sulfate to thedetection of aliphatic carboxylic acids in brine and to the determination of traceamounts of bromate in drinking water.Close-up of the mass spectrometer’s electrospray ionization(ESI) interface.Determination of 1 ppb perchlorate in the presence of1 g/L each of chloride, carbonate and sulfate (chromatogramsin SIM – mode).Separation column: Metrosep A Supp 5 – 100(6.1006.510)Eluent:Flow rate:30 mmol/L NaOH, 30% methanol0.8 mL/minDetermination of five aliphatic carboxylic acids in 100 g/LNaCl solution [chromatograms in SIM – mode at m/z =59 (1), 73 (2), 87 (3), 101 (4), 115 (5)].Separation column: Metrosep Organic Acids – 100(6.1005.210)Eluent:0.25 mmol/L oxalic acidFlow rate:0.4 mL/minPost-column reagent: 300 mmol/L NH 3(0.25 mL/min)Sample:100 g/L NaCl solution with 1 ppmacetate (1), propionate (2), butyrate(3); 1 ppb valerate (4), capronate(5)Metrohm Information Issue 2/2005 11
Page 1 and 2: E-Mail: info@metrohm.com Internet:
Page 3 and 4: EditorialBrief portrait of Dr. Chri
Page 5: Third-party instruments in tiamofro
Page 8 and 9: 844 UV/VIS Compact ICIn the 844 UV/
Page 12 and 13: New separation columns for ICNew IC
Page 14 and 15: Metrosep A Supp 10In focus: the new
Page 16 and 17: Metrosep A Supp 10As the examples s
Page 18 and 19: Biogenic amines in fishIn order to
Page 20 and 21: 6.0262.100 Ecotrode Plus6.0262.100
Page 22 and 23: SpectrosenseTechnical specification
Page 24 and 25: DIN EN 14480Schematic diagram of th
Page 26 and 27: New Metrohm publicationsProf. Dr. L
Page 28 and 29: Book cornerBook cornerRobert A. Kel
Page 30 and 31: Literature referencesLiterature ref
Page 32 and 33: The CIA 2005 in retrospectThe 3 rd
Page 34 and 35: Metrohm worldwideTrade fairs and co
Page 36: Another world’s firstby Metrohm84

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