Chapter 2 - University of British Columbia
Chapter 2 - University of British Columbia
Chapter 2 - University of British Columbia
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26. Buys TPH, Chari R, Lee E, Zhang M, MacAulay C, Lam S, Lam WL, Ling V. (2007)<br />
Genetic changes in the evolution <strong>of</strong> multidrug resistance for cultured human ovarian cancer<br />
cells. Genes, Chromosomes and Cancer, 46(12):1069-79.<br />
Drug resistance is a common problem for cancer patients treated by chemotherapeutics. One<br />
<strong>of</strong> the mechanisms <strong>of</strong> resistance is through the multi-drug resistance phenotype which is <strong>of</strong>ten<br />
associated with the activity <strong>of</strong> ATP-binding cassette (ABC) transporters. In this study, using an<br />
ovarian cancer cell line exposed to increasing concentrations <strong>of</strong> vincristine to derive drug<br />
resistant derivatives, the genetic and gene expression pr<strong>of</strong>iles were compared between these<br />
resistant derivatives and the original cancer cell line. It was found that in while initial resistant<br />
derivatives (lines exposed to lower concentration <strong>of</strong> drug) harbored copy number and gene<br />
expression increase <strong>of</strong> ABCC1 and ABCC6, latter resistant derivatives (lines exposed to higher<br />
concentration <strong>of</strong> drug) did not have the increase in ABCC1 and ABCC6, but had an increase <strong>of</strong><br />
ABCB, suggesting the drug resistance phenotype may be a dynamic process.<br />
27. Coe BP, Lockwood WW, Girard L, Chari R, Minna JD, MacAulay C, Lam S, Gazdar AF,<br />
Lam WL. (2006) Differential regulation <strong>of</strong> cell cycle pathways in small cell and non-small cell<br />
lung cancer. <strong>British</strong> Journal <strong>of</strong> Cancer, (12):1927-35.<br />
Small cell lung cancer (SCLC) and non-small cell lung cancer (SCLC) are the two major cell<br />
types <strong>of</strong> lung cancer. While pathologically they can be distinguished, the molecular basis <strong>of</strong><br />
these two cancer types is not well understood. In this study, a whole genome integrative<br />
genetic and gene expression comparison <strong>of</strong> NSCLC and SCLC was performed and differential<br />
regulation <strong>of</strong> cell cycle pathways was identified. Specifically, NSCLC is primarily deregulated at<br />
the receptor level while SCLC is primarily deregulated at the nuclear transcription factor level.<br />
S<strong>of</strong>tware, analysis approaches, and databases<br />
28. Tsui IFL, Chari R, Buys TPH, Lam WL. (2007) Public databases and s<strong>of</strong>tware for the<br />
pathway analysis <strong>of</strong> cancer genomes. Cancer Informatics, 3:389-407.<br />
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