Chapter 2 - University of British Columbia

Figure 5.1. Advances in cancer genomic landscape post Y2K.
2009
2007
2006
2005
2004
2002
DNA nanoballs sequencing technology [3]
Breast, lung & skin cancer genomes sequen ced [4-6,11]
Human met hylomes sequen ced [12]
Acute myeloid leukemia genome sequen ced [13,14]
International Cancer Genome Consortium initiated
1000 genomes p roject launched [15]
Integrative study of glioblas toma [16]
Genome RNAi database established [9,10]
2nd gene ration human haplo type map with >3M SN Ps [17]
Next generation, massi vely parallel sequencing technolo gies
Copy number variation maps [18,19]
5-Azacytidine re-expression of met hylated cancer genes [20]
Exome sequencing mut ation detection [21]
The RNAi Consortium (TRC) [22]
Bead Arrays for bisulfite DNA methylation [23]
NIH Cancer Genome Atlas (CGA) initiated
Methylome map by MeDNA immunop recipitation [24]
First human genome haplo type map [25]
MicroRNA expression profiles classify can cers [26]
Catalogue of som atic mutations in can cer (COSMIC) [27]
Large scale RN Ai-based sc reens [28,29]
Cancer Gene Census published [30]
Large scale copy number variation in humans [31,32]
Whole genome tiling p ath CGH microarrays [33]
Tiling path analysis of human t ranscribed sequen ces [34]
Cancer Biomedical Informatics Grid (caBIG) launched [8]
The Ensembl genome d atabase project [35]
The human genome b rowser at UCSC [36]
BeadArray genotyping pl atforms [37]
Concept of oncogene addi ction [38,39]
First human genome sequen ces [40,41]
CGAP launched [42,43]
Figure 5.1. Advances in cancer genomic landscape post Y2K. The timeframe of events
are estimated based on time of publication.
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