ACE C18-AR and C18-PFP - Hplc.eu
ACE C18-AR and C18-PFP - Hplc.eu
ACE C18-AR and C18-PFP - Hplc.eu
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®<strong>ACE</strong>HPLC / UHPLC ColumnsSummary: Unwanted Selectivity Changes44Pressure induced k <strong>and</strong> changes may be seen forany manufacturer phases under UHPLC conditionsChanges in selectivity <strong>and</strong> retention may be significantwith ionised analytes <strong>and</strong> large MW analytes a , but theimpact on n<strong>eu</strong>tral molecules is typically smallerCurrent discussions / theory focus on changes inanalyte molar volume as the principle cause forchanges in k <strong>and</strong> observedSuccessful HPLC ↔ UHPLC possible...the analyst justneeds to be vigilanta Fallas et al. / J. Chromatogr. A 1209 (2008) 195–205
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