Background and Significance

General Comments• Check to see that the references are correctly numbered. 1• A reference manager such as Endnote is stronglyrecommended. 2• References can be downloaded directly from PubMedthereby avoiding errors in the bibliography (veryirritating when the reviewer wants to look somethingup).• More efficient when reformatting is necessary.• “Check carefully for typos. In the age of spellcheck, typosare extremely annoying to reviewers, especially if there area large number of them.” 3 1. Kessel D, Chest 130: 296 20062. www.endnote.com3. Joel Karliner, Cardiology, UCSF