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Background<br />
More and more pharmaceutical products are reach<strong>in</strong>g<br />
the market as multiparticulate dosage forms,<br />
ma<strong>in</strong>ly as pellets. The healthcare sector also frequently<br />
selects pellets as an optimal marketable form<br />
of functional food. As there is quite a number of existent<br />
techniques relat<strong>in</strong>g to the production of pellets,<br />
it is often very difficult for a formulator or market<strong>in</strong>g<br />
manager to make a choice, s<strong>in</strong>ce every technique<br />
claims to be optimal.<br />
This workshop is aimed at elaborat<strong>in</strong>g the advantages<br />
and drawbacks of the <strong>in</strong>dividual techniques, focus<strong>in</strong>g<br />
on the optimal spectrum of each one, but also consider<strong>in</strong>g<br />
the economical and ergonomical aspects of<br />
manufactur<strong>in</strong>g processes. On special request of various<br />
participants, this workshop has been extended<br />
to <strong>in</strong>clude lectures on the ma<strong>in</strong> excipients for pelletiz<strong>in</strong>g<br />
and pellet coat<strong>in</strong>g, on functional pellet coat<strong>in</strong>g,<br />
compression of pellets <strong>in</strong>to tablets, capsule fill<strong>in</strong>g and<br />
the most suitable capsule materials. All speakers are<br />
specialized, experienced and renowned experts from<br />
science and <strong>in</strong>dustry.<br />
Speakers Topics<br />
Dr. Jörg Brunemann<br />
Syntapharm, Germany<br />
Dr. Dom<strong>in</strong>ique Cadé<br />
Pfizer, France<br />
Dr. Pascale Gauthier<br />
University of Clermont-Ferrand, France<br />
Michael Jacob<br />
<strong>Glatt</strong> Weimar, Germany<br />
Dr. Bruno Leclercq<br />
FMC, Belgiium<br />
Dr. Atul Mehta<br />
Mehta Consult<strong>in</strong>g, USA<br />
Prof. Dr. Mike Newton<br />
The London School of Pharmacy, UK<br />
Dr. Raphael Plüss<br />
Encap BioSystems Inc., Switzerland<br />
Dr. Norbert Pöll<strong>in</strong>ger<br />
<strong>Glatt</strong> Pharmaceutical Services, Germany<br />
Prof. Dr. Agba D. Salman<br />
Sheffield University, UK<br />
Dr. Thilo Schmierer<br />
Pfizer, France<br />
Dr. Karlhe<strong>in</strong>z Seyfang<br />
Harro Höfliger, Germany<br />
Dr. Anke Stroyer Bayer<br />
HealthCare AG, Germany<br />
t<br />
Workshop no. 146<br />
Multiparticle<br />
Dosage<br />
Form<br />
l Pellets as oral multiparticulate dosage forms<br />
l High Shear pelletiz<strong>in</strong>g<br />
l Cont<strong>in</strong>uous fluid bed pelletization<br />
l Preparation of pellets by extrusion / spheronization<br />
l Pelletiz<strong>in</strong>g by solution, suspension and dry powder layer<strong>in</strong>g<br />
l Rotor pelletization techniques<br />
l Innovative technologies for the development and production of<br />
controlled release pellets<br />
l Case study: Solid state <strong>in</strong>teractions between proton pump <strong>in</strong>hibitor<br />
omeprazole and enteric coat<strong>in</strong>g polymers<br />
l The ma<strong>in</strong> excipients for pelletiz<strong>in</strong>g and pellet coat<strong>in</strong>g<br />
l Functional filmcoat<strong>in</strong>g of pellets<br />
l Adjust<strong>in</strong>g desired drug release k<strong>in</strong>etics from ethylcellulose-coated pellets<br />
l Compatibility tests to perform with capsules<br />
l Capsule systems today and tomorrow<br />
l Capsule fill<strong>in</strong>g techniques<br />
l Excursion to Capsugel <strong>in</strong> Colmar (France) to look at <strong>in</strong>novative<br />
capsule technology<br />
l Pelletiz<strong>in</strong>g by prill<strong>in</strong>g: Theory and practise (demo)<br />
l Process demonstrations:<br />
direct pelletiz<strong>in</strong>g<br />
suspension layer<strong>in</strong>g<br />
capsule fill<strong>in</strong>g<br />
B<strong>in</strong>zen, 8 -10 September 2009<br />
To register www.ttc-b<strong>in</strong>zen.de<br />
International Times No. 27 · March 2009<br />
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