Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Paper n tested n follow-upMean age(years) Sex Inclusions ExclusionsDuration offollow-up MACELewis 1994 146 93 82 50 48/93 male Low-risk patients (based onelectrocardiographic andclinical findings).ECGs diagnostic of infarction orischaemia6–37 months MIPolananczyk 276 276 59 130/2761998 147 maleLower risk for major cardiaceventsHigh risk (Goldman et al). ECGischaemia6 months PTCA, CABG or MIRamakrishna 125 125 55 71/1252005 148 maleIntermediate-risk profile forcardiovascular eventsECG ischaemia 6 months MI or HFSarullo 190 190 57 127/1902000 149 maleLow-risk patients (Pryormonogram)ECG diagnostic of infarction orischaemiaMinimum12 monthsCardiac death, MI,PTCA, CABGTsakonis 1991 150 28 28 45 23/28 male Unstable CAD. No prior cardiachistory, normal or near normalECG, able to exercise on atreadmillPrior cardiac history, ECGischaemia1–12 months Cardiac eventsAMI, acute myocardial infarction; HF, heart failure; PTCA, percutaneous transluminal coronary angioplasty.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.77