Systematic review, meta-analysis and economic modelling of ...
Systematic review, meta-analysis and economic modelling of ...
Systematic review, meta-analysis and economic modelling of ...
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Assessment <strong>of</strong> diagnostic <strong>and</strong> prognostic accuracyTABLE 26 Characteristics <strong>of</strong> prognostic studies <strong>of</strong> CTCA <strong>and</strong> CAC scoringPaper Technology Beta-blocker n a <strong>and</strong> sexAge (years)Goldstein 64-slice CTCA Yes 99 48, 42/992007 131 (43%) maleHoll<strong>and</strong>er 64-slice CTCA Yes 588 46, 193/5882009 132 (40%) maleHoll<strong>and</strong>er 64-slice CTCA Yes 568 47, 252/5682009 133 (44%) maleLaudon CT CAC2010 151 scoringNo 263 48, 159/263(60%) maleMiller 64-slice CTCA Yes 30 51, 13/302011 134 (43%) maleRubinshtein 64-slice CTCA Yes 58 56, 21/582007 135 (64%) maleSchlett 64-slice CTCA Yes 368 53, 226/3682011 136 (61%) maleShuman 64-slice CTCA Yes 81 55, 49/812010 137 (60%) maleTIMI, thrombolysis In myocardial infarction.a Number receiving CTCA.b Other than contraindications to CTCA.InclusionDiagnosticcriteria Exclusion criteria b criteria for CTCADuration <strong>of</strong>follow-up MACELow-risk chestpain within12 hoursDiagnostic ECG changes,known CAD, positivebiomarkers> 70% = positive< 26% = negative26–70% = inter6 months Death, MI,revascularisationLow-risk chestpainComorbidity, knowncardiac disease, cocaineuse≥ 70% = positive< 50% = negative50–69% = inter1 year Cardiovascular death,MILow-risk chestpainComorbidity, knowncardiac disease, cocaineuse≥ 70% = positive< 50% = negative50–69% = inter30 days Cardiac death, MI,revascularisation, stroke<strong>and</strong> hospitalisation foranginaLow-/intermediateriskchest painIschaemic ECG,elevated biomarkers,haemodynamicallyunstableCalcium score>0 30 days,1 + 5 yearsMI, PCI, CABG, deathLow-/intermediateriskchest painwithin 12 hoursDiagnostic ECG changes,positive biomarkers,needing hospitaladmissionNormal, nonobstructive,obstructive90 days MI, death, unplannedrevascularisationIntermediaterisksuspectedACSDiagnostic ECG changes,positive biomarkers,comorbidities≥ 50% stenosis 15 months Death, MI, PCI, CABG> 5 minutes<strong>of</strong> chest painwithin 24 hoursAbnormal ECG, elevatedtroponin> 50% stenosis 2 years Not statedLow-/moderateriskchest painDiagnostic ECG changes,positive biomarkers, TIMIscore <strong>of</strong> > 4, knowncardiac disease≥ 50% stenosis 3, 6, 12 months Cardiac death, MI,revascularisation72NIHR Journals Library