Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1ContentsGlossaryList of abbreviationsExecutive summaryixxixiiiChapter 1 Background 1Description of health problem 1Current service provision 3Description of technology under assessment 4Chapter 2 Research questions 7Rationale for the study 7Overall aims and objectives of assessment 7Chapter 3 Assessment of diagnostic and prognostic accuracy 9Methods for reviewing diagnostic accuracy 9Results of the reviews 16Chapter 4 Assessment of cost-effectiveness evidence 81The diagnostic phase model 81The prognostic phase model 96Chapter 5 Discussion 107Statement of principal findings 107Strengths and limitations of the study 113Uncertainties 115Assessment of factors relevant to the NHS and other parties 115Chapter 6 Conclusions 117Implications for service provision 117Suggested research priorities 118Acknowledgements 119References 121Appendix 1 Examples of search strategies used 133Appendix 2 Methodology checklist: the modified QUADAS tool for studies of diagnostictest accuracy 141Appendix 3 Studies excluded from the biomarkers review 143Appendix 4 Studies excluded from the computed tomographic coronary angiographyand exercise electrocardiography review 151© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.vii