Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1TABLE 23 Multivariate analyses reported in prognostic biomarker studies (continued)Study Biomarker ThresholdBiomarkerselection Analysis FindingGarcia-H-FABP 6.2 ng/ml None Multivariate HR2011 49Valdecasas(with Tn)Ilva 2009 50 H-FABP 10.4 µg/l None Multivariate OR(with Tn)2.5 (95% CI 1.3 to 4.8)Non-significantMcCann 2009 111 H-FABP 5 ng/ml None Multivariate OR 2.7 (95% CI 1.1 to 6.4)Viswanathan2010 121 H-FABP Quartiles Tn –ve Multivariate HR Q1: ReferenceQ2: 1.5 (95% CI 0.7 to 3.4)Q3: 3.1 (95% CI 1.1 to 8.8)Q4: 16.7 (95% CI 2.2 to 127.1)Yamashita H-FABP None: continuous None Multivariate OR2010 122 (with Tn)Consuegra- IMA 93.3 U/ml None Multivariate HRSanchez 2008 95 (with Tn)1.001 (95% CI 0.998 to 1.003)1.04 (95% CI 1.01 to 1.07)Apple 2007 87 MMP9 233.7 µg/l None Multivariate RR 1.6 (95% CI 0.6 to 4.6)Apple 2007 87 MPO 125.6 µg/l None Multivariate RR 1.7 (95% CI 0.8 to 3.7)Apple 2011 88 MPO 633 pmol/l None Multivariate HR 2.4 (95% CI 1.3 to 4.6)Brennan 2003 91 MPO Quartiles Tn –ve Multivariate OR Q1: ReferenceQ2: 1.9 (95% CI 1.0 to 3.8)Q3: 4.4 (95% CI 2.3 to 8.4)Q4: 3.9 (95% CI 2.0 to 7.7)Jaffery 2008 101 Myoglobin 200 ng/ml None Multivariate HR(with Tn)Kontos 2007 104 Myoglobin 90 ng/ml None Multivariate OR(with Tn)Sonel 2000 117 Myoglobin 100 µg/ml None Multivariate OR(with Tn)Svensson Myoglobin 50 ng/ml None Multivariate OR2004 118 (with Tn)1.60 (95% CI 1.21 to 2.11)2.8 (95% CI 2.1 to 3.7)Non-significantNon-significantVan Domberg Myoglobin 64 µg/ml (women),2000 120 76 µg/ml (men)NoneMultivariate OR(with Tn)2.2 (95% CI 0.7 to 6.7)Mockel 2008 86 NT-proBNP 145 ng/ml None Multivariate OR(with Tn)2.6 (95% CI 1.2 to 5.7)Apple 2007 87 NT-pro-BNP < 75 years,125 ng/l; ≥ 75 years,450 ng/lNone Multivariate RR 2.4 (95% CI 0.9 to 6.3)Eggers 2008 85 NT-pro-BNP 550 ng/l None Multivariate OR(with Tn)Eggers 2008 97 NT-pro-BNP Not stated None Multivariate OR(with Tn)Jernberg 2002 102 NT-pro-BNP Quartiles None Multivariate RR(with Tn)2.7 (95% CI 1.0 to 7.3)1.0 (95% CI 0.7 to 1.5)Q1: ReferenceQ2: 1.8 (95% CI 0.7 to 5.1)Q3: 3.0 (95% CI 1.1 to 7.8)Q4: 5.4 (95% CI 2.0 to 14.4)McCann 2009 111 NT-pro-BNP 1371 ng/l None Multivariate OR 2.7 (95% CI 1.4 to 5.2)continued© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.65