Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1TABLE 22 Univariate analyses reported in prognostic biomarker studies (continued)Study Biomarker ThresholdBiomarkerselection Analysis FindingMcCann 2009 111 MPO 421 ng/ml None Univariate OR 0.8 (95% CI 0.4 to 1.6)Cameron 2007 94 Myoglobin 61 ng/ml None Univariate RR 3.1 (95% CI 1.7 to 5.7)De Winter 1996 96 Myoglobin 90 ng/ml None Univariate RR 1.0 (95% CI 0.3 to 3.2)Fromm 2001 98 Myoglobin 85 ng/ml None Univariate RR 1.6 (95% CI 1.1 to 2.9)Green 200099 Myoglobin 69 ng/ml None Univariate RR 3.4 (95% CI 2.2 to 5.1)Hills 2003 100 Myoglobin 100 ng/ml None Univariate RR 2.2 (95% CI 1.3 to 4.0)Jaffery 2008 101 Myoglobin 200 ng/ml None NR –Kontos 2007 104 Myoglobin 90 ng/ml None Univariate RR 3.7 (95% CI 2.8 to 4.7)Lim 2002 106 Myoglobin 116 ng/ml All Univariate OR 12.5 (95% CI 2.1 to 71)Mathew 1999 110 Myoglobin 92 µg/l None Univariate RR 2.5McCord 2003 112 Myoglobin 200 ng/ml None Sensitivity andspecificity74.8 (95% CI 65 to 83) and70.4 (95% CI 67 to 74)Newby 2001 114 Myoglobin 105 ng/ml None NR –Ordonez-Llanos Myoglobin Quartiles None Univariate OR 5.2 (95% CI 3.0- 9.2)2006 115Sonel 2000 117 Myoglobin 100 µg/ml None Univariate OR 2.5 (95% CI 1.3 to 4.6)Svensson 2004 118 Myoglobin 50 ng/ml None Fishers exact test p = 0.07Symanski 2007 119 Myoglobin 82 ng/ml None AUROC 0.78 (95% CI 0.72 to 0.83)Van Domberg Myoglobin 64 µg/ml (women),2000 120 76 µg/ml (men)NoneNRCameron 2007 94 NT-pro-BNP 280 ng/ml None Univariate RR 3.0 (95% CI 1.6 to 5.7)Mockel 2008 86 NT-pro-BNP 145 ng/ml None Univariate OR 3.8 (95% CI 1.9 to 7.5)Apple 2007 87 NT-pro-BNP < 75 years,125 ng/l ≥ 75 years,450 ng/lNone Univariate RR 2.9 (95% CI 1.1 to 7.4)Eggers 2008 85 NT-pro-BNP 550 ng/l None Chi-squared test p < 0.001Eggers 2008 97 NT-pro-BNP Not stated None Univariate OR 1.8 (95% CI 1.4 to 2.3)Jernberg 2002 102 NT-pro-BNP Quartiles None Log-rank test Q1: ReferenceQ2: p = 0.005Q3: p < 0.001Q4: p < 0.001McCann 2009 111 NT-pro-BNP 1371 ng/l None Univariate OR 5.4 (95% CI 3.0 to 9.7)Yamashita 2010 122 NT-pro-BNP None: continuous None Univariate OR 1.0 (95% CI 1.0 to 1.0)Body 2011 46 PAPP-A Tertiles Tn –ve Mantel–Haenszel testp = 0.619Kavsak 2009 103 PAPP-A Tertiles None Log-rank test p = 0.05Laterza 2004 105 PAPP-A 0.22 mIU/l None Univariate RR 4.7 (95% CI 2.2 to 9.8)Lund 2003 107 PAPP-A 2.9 mIU/l Tn –ve Univariate RR 2.3 (95% CI 1.1 to 5.0)McCann 2009 111 PAPP-A 12.4 ng/ml None Univariate OR 1.1 (95% CI 0.6 to 2.2)continued© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.63