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Assessment of diagnostic and prognostic accuracyTABLE 20 Characteristics of prognostic studies of biomarkers used in suspected ACSStudy Population nAge (years) andsex Follow-up MACEApple 2007 52 All 457 NR 4 months Cardiac death, MI,revascularisationApple 2011 88 All 400 Mean age 56, 228(57%) men6 months Cardiac death, MI,revascularisationBholasigh 2003 89< 6 hours, ECG,TnI –ve382 Mean age 57, 215(56%) male6 months Cardiac death, MI, admissionBlum 2003 90Age < 55 years,ECG, CK-MB –ve40 Mean age 45, 38(95%) men6 months Cardiac death, MI,revascularisationBody 2011 46
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1TABLE 20 Characteristics of prognostic studies of biomarkers used in suspected ACS (continued)Study Population nAge (years) andsex Follow-up MACEKontos 2007 104Low clinical risk,ECG3461 Mean age 59, 1737(50%) men1 year DeathLaterza 2004 105 All 346 Mean age 57, 166(48%) menLim 2002 106 < 8 hours, ECG 37 Mean age 58, 17(73%) menLund 2003 107 Tn –ve 136 Mean age 66, 69(50%) menManini 2009 108 ECG 106 Mean age 60, 57(54%) menMarkovic 2010 109 ECG 102 Mean age 63, 70(70%) menMathew 1999 110 < 24 hours, ECG 214 Mean age 59, 151(71%) men1 month Death, MI, revascularisation3 months Death, stroke, hospitalisation,MI, revascularisation6 months Death, MI, revascularisation30 days Death, MI, revascularisation30 days Death, MI3 months Death, MI, UA, revascularisationMcCann 2009 111Cardiac-typechest pain555 Mean age 62, 386(70%) men1 year Death, MIMcCord 2003 112 ECG 764 Mean age 64, 345(45%) men30 days Death, MIMenown 2003 113Cardiac-typechest pain391 Mean age 63 1 year Death, MIMockel 2008 86 All 432 Mean age 60, 261(60%) menNewby 2001 114 ECG 1005 Mean age 51,423/851 (50%) menOrdonez-Llanos < 24 hours 1410 Mean age 63, 9062006 115 (64%) men42 days Cardiac death, MI, UA, HF,revascularisation30 days Death, MI1 year Death, MI, UA, revascularisationPonitz 116Stronglysuspected ACS870 Mean age 70, 531(61%) men2 years Death, MIPotsch 2006 51 < 12 hours 980 Mean age 65, 535(55%) menInpatientstayCardiac death, MI,revascularisationSonel 2000 117 All 247 Mean age 52, 133(54%) menSvensson 2004 118 < 6 hours 511 Mean age 69,293/500 (50%) men6 months Death, MI, UA, revascularisation1 year DeathSymanski 2007 119High clinicalprobability ACS336 Mean age 66, 180(54%) men30 day DeathVan Domberg All 163 Mean age 62, 1242000 120 (76%) menViswanathan All 955 Mean age 60, 5772010 121 (60%) men3 years Death> 1 year Death, MIYamashita 2010 122 All 162 Mean age 64, 107(66%) menInpatientstayCardiac deathECG, selected with normal or non-diagnostic ECG; CK-MB –ve, selected with normal CK-MB; HF, new-onset heart failure;LTA, life-threatening arrhythmia; Tn –ve, selected with normal troponin; UA unstable angina.Population: Selection criteria other than presenting symptoms, age > 20–40 years, comorbidities or administrativecriteria.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.59
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Health Technology AssessmentVOLUME
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DOI: 10.3310/hta17010 Health Techno
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ContentsAppendix 5 Expected discoun
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BackgroundTABLE 1 Hospital admissio
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Background2. investigation of the c
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BackgroundComputed tomographic coro
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Discussionspecificity were 62% (95%
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Discussionneed for revascularisatio
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Discussionchanges in sensitivity an
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Discussionuncertainty about these p
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Discussiontroponin assays have bett
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ConclusionsSuggested research prior
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Appendix 144. heart-type fatty acid
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Appendix 1135. interleukin 33.mp. (
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Appendix 313. Fernandez Portales JG
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Appendix 346. Luscher MS, Ravkilde
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Appendix 9Clinical diagnosis of NST
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Appendix 9respectively. Exercise EC
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Appendix 93. Two reviewers will mak
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Appendix 9The methodology used in t
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Appendix 9ES (Information Resources
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Appendix 923. Westwood ME, Whiting
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