Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1TABLE 16 Index and reference standard tests used in studies of other biomarkersStudyIndex test analyser(timing is at presentation unlessotherwise stated) Threshold Reference test assay and timingReference Tndiagnosticthreshold (µg/l)MI prevalencein sample (%)Apple 2009 55 CD40L, R&D Systems ELISA 1.08 ng/l Dade Behring Dimension or Stratus CS TnI at 8 hoursafter presentation0.1 5Apple 2009 55 MPO, Assay Designs ELISA 125 µg/l Dade Behring Dimension or Stratus CS TnI at 8 hoursafter presentation0.1 5Apple 2009 55 MMP9, Assay Designs ELISA 233 µg/l Dade Behring Dimension or Stratus CS TnI at 8 hoursafter presentation0.1 5Apple 2009 55 CRP, Dade Behring Dimension 1.0 and 3.0 mg/l Dade Behring Dimension or Stratus CS TnI at 8 hoursafter presentation0.1 5Apple 2009 55 NT-pro-BNP, Roche Elecsys 125 ng/l age < 75 years,450 ng/l age > 75 yearsDade Behring Dimension or Stratus CS TnI at 8 hoursafter presentation0.1 5Bassan 2005 56 Biosite immunofluorescence BNP assay 100 pg/ml Dade Behring TnI; within 9 hours post-admission; 1.0 11Body 2011 57 BNP Alere Fluorescence Immunoassay 73 ng/ml cTnT; Roche Elecsys; at least 12 hours after symptomonset0.01 18Body 2011 57 MPO Alere Fluorescence Immunoassay 510 pM cTnT; Roche Elecsys; at least 12 hours after symptomonset0.01 18Body 2011 46 PAPP-A, Demeditec Diagnostics ultrasensitiveELISA4.4 µg/l Roche fourth generation TnT at 12 hours 0.035 18Body 2011 46 CD40L, R&D Systems Quantikine kit 17.2 ng/l Roche fourth-generation TnT at 12 hours 0.035 18continued© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.51