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Assessment of diagnostic and prognostic accuracyRepresentative spectrum?Acceptable reference standard?Acceptable delay between tests?Partial verification avoided?Differential verification avoided?Incorporation avoided?Reference standard results blinded?Index test results blinded?Amodio 2007 52 +++++++?Body 2011 58 ++++++??Cete 2010 46 ++++++??Di Serio 2005 63 ??+?++??Ecollan 2007 64 ++++++??Eggers 2004 18 ++++++?+Garcia-Valdecasas 2011 49 ++?+++++Hjortshoj 2010 68 ++++++??Ilva 2005 69 ++++++??Keller 2010 71 ++++++++Liao 2009 74 +??++?––Mion 2007 77 –+++?+??Penttilä 2002 79 ++?+??+?FIGURE 21 Quality assessment of diagnostic studies of myoglobin.Representative spectrum?Acceptable reference standard?Acceptable delay between tests?Partial verification avoided?Differential verification avoided?Incorporation avoided?Reference standard results blinded?Index test results blinded?Yes (high quality)UnclearNo (low quality)0% 25% 50% 75% 100%FIGURE 22 Methodological quality summary of diagnostic studies of myoglobin.48NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Study TP FP FN TN Sensitivity Specificity Sensitivity SpecificityAmodio 2007 52 40 53 70 353 0.40 (0.32 to 0.49) 0.87 (0.84 to 0.90)Body 2011 57 76 104 53 472 0.59 (0.51 to 0.67) 0.82 (0.79 to 0.85)Cete 2010 58 42 14 31 137 0.58 (0.48 to 0.68) 0.90 (0.85 to 0.94)Di Serio 2005 63 12 3 4 11 0.68 (0.51 to 0.82) 0.80 (0.59 to 0.93)Ecollan 2007 64 31 20 17 40 0.64 (0.53 to 0.75) 0.68 (0.56 to 0.79)Eggers 2004 18 27 7 16 126 0.61 (0.49 to 0.73) 0.94 (0.89 to 0.97)Garcia-Valdecasas 2011 49 40 44 25 56 0.63 (0.52 to 0.73) 0.58 (0.48 to 0.67)Hjortshoj 2010 68 24 8 13 62 0.63 (0.50 to 0.75) 0.88 (0.80 to 0.94)Ilva 2005 69 84 44 64 339 0.57 (0.50 to 0.65) 0.88 (0.85 to 0.91)Keller 2010 71 74 53 47 343 0.61 (0.53 to 0.69) 0.87 (0.83 to 0.90)Liao 2009 74 41 15 13 5 0.74 (0.62 to 0.83) 0.36 (0.17 to 0.57)Mion 2007 77 30 5 12 85 0.67 (0.54 to 0.78) 0.93 (0.87 to 0.97)Penttilä 2002 79 81 56 49 254 0.62 (0.54 to 0.70) 0.82 (0.78 to 0.86)Pooled effect 0.62 (0.54 to 0.69) 0.83 (0.72 to 0.90)Predictive effect 0.62 (0.35 to 0.83) 0.83 (0.35 to 0.98)0 0.2 0.4 0.6 0.8 1.00 0.2 0.4 0.6 0.8 1.0FIGURE 23 Meta-analysis of studies of myoglobin.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.49
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Health Technology AssessmentVOLUME
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DOI: 10.3310/hta17010 Health Techno
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ContentsAppendix 5 Expected discoun
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Page 22 and 23: BackgroundTABLE 1 Hospital admissio
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Page 26 and 27: BackgroundComputed tomographic coro
Page 28 and 29: Research questionsiii. the diagnost
Page 30 and 31: Assessment of diagnostic and progno
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Discussionspecificity were 62% (95%
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Discussionneed for revascularisatio
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Discussionchanges in sensitivity an
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Discussionuncertainty about these p
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Discussiontroponin assays have bett
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ConclusionsSuggested research prior
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Appendix 144. heart-type fatty acid
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Appendix 1135. interleukin 33.mp. (
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Appendix 147. 37 and 45 (529)48. li
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Appendix 313. Fernandez Portales JG
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Appendix 346. Luscher MS, Ravkilde
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Appendix 316. Rao SV, Ohman EM, Gra
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Appendix 9Clinical diagnosis of NST
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Appendix 9respectively. Exercise EC
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Appendix 93. Two reviewers will mak
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Appendix 9The methodology used in t
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Appendix 9ES (Information Resources
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Appendix 923. Westwood ME, Whiting
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