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Assessment of diagnostic and prognostic accuracyRepresentative spectrum?Acceptable reference standard?Acceptable delay between tests?Partial verification avoided?Differential verification avoided?Incorporation avoided?Reference standard results blinded?Index test results blinded?Christenson 2001 61 ?+++++??Collinson 2006 48 ++++++??Hjortshoj 2010 68 ++++++??Keating 2006 70 ++++++++FIGURE 18 Quality assessment of diagnostic studies of IMA.Representative spectrum?Acceptable reference standard?Acceptable delay between tests?Partial verification avoided?Differential verification avoided?Incorporation avoided?Yes (high quality)UnclearNo (low quality)Reference standard results blinded?Index test results blinded?0% 25% 50% 75% 100%FIGURE 19 Methodological quality summary of diagnostic studies of IMA.44NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Study TP FP FN TN Sensitivity Specificity Sensitivity SpecificityChristenson 2001 61 29 58 6 131 0.82 (0.68 to 0.92) 0.69 (0.62 to 0.75)Collinson 2006 48 18 322 19 179 0.54 (0.37 to 0.69) 0.36 (0.32 to 0.40)Hjortshoj 2010 68 32 36 5 34 0.85 (0.72 to 0.94) 0.48 (0.37 to 0.60)Keating 2006 70 35 203 7 32 0.82 (0.69 to 0.92) 0.14 (0.10 to 0.19)Pooled effect 0.78 (0.50 to 0.93) 0.40 (0.12 to 0.75)Predictive effect 0.77 (0.19 to 0.98) 0.39 (0.02 to 0.95)0 0.2 0.4 0.6 0.8 1.00 0.2 0.4 0.6 0.8 1.0FIGURE 20 Meta-analysis of studies of IMA.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.45
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Health Technology AssessmentVOLUME
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DOI: 10.3310/hta17010 Health Techno
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ContentsAppendix 5 Expected discoun
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Page 22 and 23: BackgroundTABLE 1 Hospital admissio
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Page 26 and 27: BackgroundComputed tomographic coro
Page 28 and 29: Research questionsiii. the diagnost
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Discussionspecificity were 62% (95%
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Discussionneed for revascularisatio
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Discussionchanges in sensitivity an
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Discussionuncertainty about these p
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Discussiontroponin assays have bett
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ConclusionsSuggested research prior
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Appendix 144. heart-type fatty acid
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Appendix 1135. interleukin 33.mp. (
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Appendix 147. 37 and 45 (529)48. li
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Appendix 313. Fernandez Portales JG
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Appendix 346. Luscher MS, Ravkilde
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Appendix 316. Rao SV, Ohman EM, Gra
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Appendix 9Clinical diagnosis of NST
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Appendix 9respectively. Exercise EC
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Appendix 93. Two reviewers will mak
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Appendix 9The methodology used in t
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Appendix 9ES (Information Resources
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Appendix 923. Westwood ME, Whiting
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