Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Study TP FP FN TN Sensitivity Specificity Sensitivity SpecificityBody 2011 57 97 63 32 513 0.76 (0.68 to 0.82) 0.89 (0.86 to 0.91)Di Serio 2005 63 16 4 0 10 0.89 (0.76 to 0.97) 0.74 (0.51 to 0.90)Garcia-Valdecasas 2011 49 53 50 12 50 0.82 (0.72 to 0.89) 0.52 (0.42 to 0.61)Haltern 2010 67 27 21 4 42 0.85 (0.73 to 0.93) 0.68 (0.56 to 0.78)Hjortshoj 2010 68 31 6 6 64 0.82 (0.71 to 0.91) 0.90 (0.82 to 0.96)Ilva 2009 50 84 19 39 151 0.70 (0.62 to 0.77) 0.89 (0.83 to 0.93)McCann 2008 76 150 85 48 132 0.76 (0.70 to 0.82) 0.62 (0.55 to 0.68)Mion 2007 77 35 6 7 84 0.82 (0.71 to 0.91) 0.92 (0.86 to 0.96)Pooled effect 0.81 (0.72 to 0.89) 0.80 (0.64 to 0.90)Predictive effect 0.81 (0.50 to 0.95) 0.80 (0.26 to 0.98)0 0.2 0.4 0.6 0.8 1.00 0.2 0.4 0.6 0.8 1.0FIGURE 16 Meta-analysis of quantitative H-FABP assays.Study TP FP FN TN Sensitivity Specificity Sensitivity SpecificityCete 2010 58 30 0 43 151 0.41 (0.30 to 0.53) 0.99 (0.98 to 1.00)Charpentier 2010 59 21 20 78 558 0.23 (0.15 to 0.32) 0.97 (0.95 to 0.98)Ecollan 2007 64 48 3 7 50 0.86 (0.75 to 0.93) 0.94 (0.86 to 0.98)LeFevre 2007 72 19 5 17 34 0.55 (0.39 to 0.70) 0.89 (0.77 to 0.96)Li 2010 73 106 10 8 103 0.92 (0.86 to 0.96) 0.91 (0.85 to 0.95)Liao 2009 74 45 14 9 6 0.84 (0.73 to 0.92) 0.36 (0.17 to 0.58)Mad 2007 75 34 12 18 43 0.66 (0.53 to 0.78) 0.80 (0.68 to 0.88)Naroo 2009 78 75 21 24 671 0.75 (0.66 to 0.83) 0.97 (0.95 to 0.98)Valle 2007 82 89 33 59 238 0.61 (0.53 to 0.68) 0.88 (0.84 to 0.92)Pooled effect 0.68 (0.46 to 0.84) 0.92 (0.77 to 0.98)Predictive effect 0.68 (0.11 to 0.97) 0.92 (0.20 to 1.00)0 0.2 0.4 0.6 0.8 1.00 0.2 0.4 0.6 0.8 1.0FIGURE 17 Meta-analysis of qualitative H-FABP assays.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.41