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Assessment of diagnostic and prognostic accuracyTABLE 9 Population characteristics of studies of H-FABPStudy Study typePopulation: age (years)and sex Inclusion criteria Exclusion criteriaTime fromsymptoms(hours)No. ofpatientsBody 2011 57 Single centre, UK Mean age 59; 430/705 (61%)maleSuspected cardiac chest painoccurring within the previous24 hoursChest trauma, renal failurerequiring dialysis, medical conditionnecessitating admission, pregnancy3.5 (median) 705Cete 2010 58 Single centre, Turkey Mean age 57; 163 (73%)maleAged > 18 years presenting to the EDwith typical chest painAtypical pain, trauma, electricalcardioversion within 24 hours,musculoskeletal disease, acute orchronic renal failure, liver diseaseNR 224Charpentier Single centre, France Mean age 57; 454 (67%)2010 59 maleChest pain due to suspected within12 hoursST elevation, traumatic cause,previous severe renal impairment, orsevere communication problems2.9 (median) 677Di Serio 2005 63 Single centre, Italy Mean age 79 (women), 65(men); 23 (77%) maleNot specified ST elevation 3.4 (mean) 30Ecollan 2007 64 Mobile units, France Mean age 68; 68 (63%) male Consecutive emergencies with chestpainPatients with cardiogenic shock orthose with any evidence of a recentchest trauma2.3 (median) 108Garcia-Single centre, France Mean age 67; 114 (69%)2011 49ValdecasasmaleChest pain > 20 minutes’ durationwithin 6 hoursChest trauma NR 165Haltern 2010 67 Single centre,GermanyMean age 69; 27/49 (55%)maleIschaemic-type chest pain Age < 18 years, interhospital transfer 4 (median) 94Hjortshoj 2010 68 Single centre, UK Median range across threegroups (60–63); 70 men,37 womenChest pain and suspected of ACS None reported NR 107Ilva 2009 50 Single centre,FinlandMean age 67; 181 (62%)maleChest pain suggesting myocardialischaemiaUncertain or > 24-hour delay fromsymptom onset4.7 (median) 293Lefevre 2007 72 Multicentre, France Mean age 61; 71/100 eligible(71%) maleNot specified None reported 5.9 (median) 75Li 2010 73 Multicentre, China Mean age 64; 163 (72%)maleChest pain > 30 minutes and< 12 hours suspected of AMINone reported 4 (median) 22736NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Study Study typePopulation: age (years)and sex Inclusion criteria Exclusion criteriaTime fromsymptoms(hours)No. ofpatientsLiao 2009 74 Single centre, China Mean age 69; 54 (73%) male Onset of acute chest pain and/or dyspnoea lasting for at least20 minutes within the last 3 hours,age > 18 yearsNone reported 2.2 (IQR1.5–2.9)(median)74Mad 2007 75 Single centre,AustriaMean age 58; 213 (76%)maleOnset of acute chest pain and/or dyspnoea lasting for at least20 minutes within the last 24 hours,age > 18 yearsNone reported 3 (IQR 2–6)(median)280McCann 2008 76 Multicentre,Northern IrelandMean age 63; 281 (68%)maleIschaemic type chest pain within24 hoursAge < 18 years, interhospitaltransfer, and previous participation inthe study5.3 (median) 415Mion 2007 77 Single centre, Italy Mean age 63; 88 (67%) male Non-consecutive patients with chestpainNone reported 3.8 (range,1.5–13.0)(median)132Naroo 2009 78 Single centre,United ArabEmiratesAge not reported; 627 (79%)maleTypical cardiac chest pain within20 minutes to 12 hoursSTEMI, renal disease, age < 20 years NR 791Valle 2008 82 Multicentre, Spain Mean age 65; 287 (68%)maleSuspected ACS with symptomsbetween 20 and 180 minutes afterpresentationNone reported 1.2 (mean) 419IQR, interquartile range; NR, not reported.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.37
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Health Technology AssessmentVOLUME
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Discussionspecificity were 62% (95%
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Discussionneed for revascularisatio
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Discussionchanges in sensitivity an
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Discussionuncertainty about these p
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Discussiontroponin assays have bett
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ConclusionsSuggested research prior
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Appendix 9ES (Information Resources
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Appendix 923. Westwood ME, Whiting
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