Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1TABLE 7 Reported results of all studies of TnI (continued)StudyBiomarkerThresholdvalueThresholddefinitionReportedsensitivityReportedspecificityMion 2007 77 Evidence Cardiac Panel 0.47 Not stated 0.548 0.978Reichlin 2009 19 ADVIA Centaur Ultra 0.04 99th percentile 0.89 0.92Reichlin 2009 19 ADVIA Centaur Ultra 0.006 LoD 0.97 0.68Reichlin 2009 19 Abbot Architect 0.028 99th percentile 0.88 0.92Reichlin 2009 19 Abbot Architect 0.032 10% CV 0.85 0.93Reichlin 2009 19 Abbot Architect 0.01 LoD 0.94 0.87Reichlin 2009 19 Roche 0.16 99th percentile 0.84 0.94Reichlin 2009 19 Roche 0.3 10% CV 0.75 0.97Reichlin 2009 19 Roche 0.1 LoD 0.92 0.88Rudolph 2010 81 Abbot Architect 0.032 10% CV 0.859 0.897TABLE 8 Reported results of all studies of TnTStudyBiomarkerThresholdvalueThresholddefinitionReportedsensitivityReportedspecificityBody 2011 46 Fourth-generation TnT 0.01 99th percentile 0.748 0.937Cete 2010 58 Not stated 0.1 Not stated 0.452 1Christ 2010 60 Fourth-generation TnT 0.01 99th percentile 0.9 0.812Christ 2010 60 Fourth-generation TnT 0.04 10% CV 0.65 0.906Christ 2010 60 HsTnT 0.003 LoD 1 0.214Christ 2010 60 HsTnT 0.014 99th percentile 0.95 0.615Collinson 2006 62 Third-generation TnT 0.03 10% CV NR NRHaltern 2010 67 Roche TnT 0.03 10% CV 0.74 1Keller 2009 20 Fourth-generation TnT 0.03 10% CV 0.637 0.972Keller 2009 20 Fourth-generation TnT 0.01 99th percentile 0.727 0.921Li 2010 73 Not stated 0.1 Not stated 0.693 0.9754McCann 2008 76 Roche TnT 0.03 10% CV 0.75 0.94Naroo 2009 78 Not stated 0.03 Not stated 0.586 0.989Reichlin 2009 19 HsTnT 0.014 99th percentile 0.95 0.8Reichlin 2009 19 HsTnT 0.002 LoD 1 0.14Reichlin 2009 19 Fourth-generation TnT 0.035 10% CV 0.72 0.97Reichlin 2009 19 Fourth-generation TnT 0.01 99th percentile 0.83 0.93Valle 2008 82 Not stated Unclear Not stated 0.19 0.99© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.31