Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Representative spectrum?Acceptable reference standard?Acceptable delay between tests?Partial verification avoided?Differential verification avoided?Incorporation avoided?Reference standard results blinded?Index test results blinded?Body 2011 46 ++++++??Cete 2010 58 ++++++??Christ 2010 60 ++?+????Collinson 2006 62 +++++++?Haltern 2010 67 ++++++??Keller 2010 71 ++++++++Li 2010 73 ++++++++McCann 2008 76 +++++?++Naroo 2009 78 ++++++++Reichlin 2009 19 ++++++++Valle 2007 82 +?+++++?FIGURE 4 Quality assessment of diagnostic studies of TnT.Representative spectrum?Acceptable reference standard?Acceptable delay between tests?Partial verification avoided?Differential verification avoided?Incorporation avoided?Reference standard results blinded?Index test results blinded?Yes (high quality)UnclearNo (low quality)0% 25% 50% 75% 100%FIGURE 5 Methodological quality summary of diagnostic studies of TnI.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.29