Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Study Index test assayIndex testthreshold (µg/l)99thpercentile,10% CV andLoD (µg/l) Reference troponin assay and timing a Reference troponinthreshold (µg/l) Prevalence MI (%)Li 2010 73 Not stated 0.1 Not stated Unspecified TnT at 12 hours 0.1 50McCann Roche Diagnostics Elecsys TnT 0.03 0.012008 76 0.030.01Roche TnT at 12 hours 0.03 48Naroo 2009 78 Electrochemiluminescenceimmunoassay0.03 Not stated Electrochemiluminescence immunoassayTnT at 6–12 hours after presentation1 13Reichlin 2009 19 Roche Diagnostics Elecsys HsTnT 0.0140.0020.0140.0130.002Abbott AxSYM TnI, Beckman CoulterAccuTnI or Roche TnT at 6–9 hours afterpresentation99th percentile 17Reichlin 2009 19 Roche Diagnostics, Elecsysfourth-generation TnT0.0350.010.010.0350.01Abbott AxSYM TnI, Beckman CoulterAccuTnI or Roche TnT at 6–9 hours afterpresentation99th percentile 17Valle 2008 82 Not stated Not stated Not stated Unspecified TnT at 6–12 hours Not stated 35a Timing is from symptoms unless otherwise specified.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.27