Systematic review, meta-analysis and economic modelling of ...
Systematic review, meta-analysis and economic modelling of ... Systematic review, meta-analysis and economic modelling of ...
Assessment of diagnostic and prognostic accuracyTABLE 5 Index and reference standard tests used in studies of TnI (continued)Study Index test assayIndex testthreshold (µg/l)99th percentile,10% CV and LoDReference troponin(µg/l) Reference troponin assay and timing a threshold (µg/l)PrevalenceMI (%)Collinson Beckman Coulter AccuTnI assay 0.03 Not stated2006 48 0.03Not statedRoche Elecsys TnT at 6 and 72 hours 0.05 7Di Serio Randox Evidence Investigator 1 1.12005 63 Not statedNot statedESC/ACC, not further specified Not specified 53Ecollan Biosite Triage (pre-hospital) 0.4 Not stated2007 64 Not stated0.05Dade Behring TnI up to 24 hours 0.07 51Garcia- ELISA (DainipponValdecasas Pharmaceutical, Japan)2011 490.6 Not stated TnI Dimension Analyser (Dade), timing notstated0.6 39Guo 2006 66 Roche CARDIAC reader 0.1 Not statedNot statedNot statedBeckman Coulter AccuTnI every 6 hours onfirst day and every 24 hours for 6 days0.33 30Ilva 2009 50 Abbott Architect 0.032 0.032Abbott Architect up to 24 hours 0.032 46Not stated0.01Keating Beckman Access 0.06 0.042006 70 Not statedNot statedTnI; Beckman Access; taken at least 8 hoursafter pain onset0.06 15Keller 2009 20 Siemens TnI-Ultra (ADVIACentaur immunoassay)0.04 0.040.03Not statedRoche Troponin T or Siemens DimensionRxL TnI within 6 hours of admission0.3 (cTnT)0.14 (cTnI)2324NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Study Index test assayIndex testthreshold (µg/l)99th percentile,10% CV and LoDReference troponin(µg/l) Reference troponin assay and timing a threshold (µg/l)PrevalenceMI (%)LeFevre (1) Dade Behring RxL2007 72 (2) Siemens Centaur(1) 0.14(2) 0.33(1) 0.070.14Not stated(2) 0.10.33Not stated(1) Dade Behring RxL or (2) SiemensCentaur TnI, timing not stated(1) 0.14(2) 0.3348Liao 2009 74 Not specified 0.5 Not stated No details 0.5 73Mion 2007 77 Evidence ® Cardiac Panel 0.47 Not statedNot statedNot statedDimension0.15 32RxL TnI, timing not specifiedReichlin Siemens TnI-Ultra (ADVIA2009 19 Centaur immunoassay)0.040.0060.040.030.006Abbott AxSYM TnI, Beckman CoulterAccuTnI or Roche TnT at 6–9 hours afterpresentation99th percentile 17Reichlin Abbott Architect TnI 0.0282009 19 0.0320.010.0280.0320.01Abbott AxSYM TnI, Beckman CoulterAccuTnI or Roche TnT at 6–9 hours afterpresentation99th percentile 17Reichlin Roche TnI 0.162009 19 0.30.10.160.30.1Abbott AxSYM TnI, Beckman CoulterAccuTnI or Roche TnT at 6–9 hours afterpresentation99th percentile 17Rudolph Abbott Architect 0.032 Not stated2010 81 0.0320.032Abbott Architect, timing not stated 0.032 36ACC, American College of Cardiology; cTNI, cardiac troponin I; cTNT, cardiac troponin T; ESC, European Society of Cardiology.a Timing is from symptoms unless otherwise specified.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.25
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DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Study Index test assayIndex testthreshold (µg/l)99th percentile,10% CV <strong>and</strong> LoDReference troponin(µg/l) Reference troponin assay <strong>and</strong> timing a threshold (µg/l)PrevalenceMI (%)LeFevre (1) Dade Behring RxL2007 72 (2) Siemens Centaur(1) 0.14(2) 0.33(1) 0.070.14Not stated(2) 0.10.33Not stated(1) Dade Behring RxL or (2) SiemensCentaur TnI, timing not stated(1) 0.14(2) 0.3348Liao 2009 74 Not specified 0.5 Not stated No details 0.5 73Mion 2007 77 Evidence ® Cardiac Panel 0.47 Not statedNot statedNot statedDimension0.15 32RxL TnI, timing not specifiedReichlin Siemens TnI-Ultra (ADVIA2009 19 Centaur immunoassay)0.040.0060.040.030.006Abbott AxSYM TnI, Beckman CoulterAccuTnI or Roche TnT at 6–9 hours afterpresentation99th percentile 17Reichlin Abbott Architect TnI 0.0282009 19 0.0320.010.0280.0320.01Abbott AxSYM TnI, Beckman CoulterAccuTnI or Roche TnT at 6–9 hours afterpresentation99th percentile 17Reichlin Roche TnI 0.162009 19 0.30.10.160.30.1Abbott AxSYM TnI, Beckman CoulterAccuTnI or Roche TnT at 6–9 hours afterpresentation99th percentile 17Rudolph Abbott Architect 0.032 Not stated2010 81 0.0320.032Abbott Architect, timing not stated 0.032 36ACC, American College <strong>of</strong> Cardiology; cTNI, cardiac troponin I; cTNT, cardiac troponin T; ESC, European Society <strong>of</strong> Cardiology.a Timing is from symptoms unless otherwise specified.© Queen’s Printer <strong>and</strong> Controller <strong>of</strong> HMSO 2013. This work was produced by Goodacre et al. under the terms <strong>of</strong> a commissioning contract issued by the Secretary <strong>of</strong> Statefor Health. This issue may be freely reproduced for the purposes <strong>of</strong> private research <strong>and</strong> study <strong>and</strong> extracts (or indeed, the full report) may be included in pr<strong>of</strong>essional journalsprovided that suitable acknowledgement is made <strong>and</strong> the reproduction is not associated with any form <strong>of</strong> advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials <strong>and</strong> Studies Coordinating Centre, Alpha House, University <strong>of</strong> Southampton SciencePark, Southampton SO16 7NS, UK.25
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