Systematic review, meta-analysis and economic modelling of ...

Assessment of diagnostic and prognostic accuracyTABLE 4 Population characteristics of studies of TnTStudy Study typePopulation: age (years) andsex Inclusion criteria Exclusion criteriaTime fromsymptoms(hours)No. ofpatientsBody 2011 46 Single centre, UK Mean age 59, 434 (61%) male Suspected cardiac chest painoccurring within the previous24 hoursChest trauma, renal failurerequiring dialysis, medical conditionnecessitating admission, pregnancy3.5 (median) 713Cete 2010 58 Single centre, Turkey Mean age 57, 163 (73%) male Aged > 18 years presenting tothe ED with typical chest painAtypical chest pain, musculoskeletaltrauma, electrical cardioversionwithin the last 24 hours,musculoskeletal disease, acute orchronic renal failure, liver diseaseNR 224Christ 2011 60 Single centre, Germany Mean age 66, 87 (64%) male Acute chest pain of possiblecoronary originNo other criteria reported 48%< 6 hours137Collinson 2006 62 Multicentre, UK Median age 60, 150 (70%)maleChest pain due to suspectedACS within 24 hoursSTEMI 3 (median) 213Haltern 2010 67 Single centre, Germany Mean age 69, 27/49 (55%)maleIschaemic-type chest pain Age < 18 years, interhospitaltransfer4 (median) 94Keller 2010 71 Multicentre, Germany Mean age 61, 920 (66%) male Aged 18–85 years, with anginapectoris or equivalent symptomsTrauma or major surgery within thelast 4 weeks, pregnancy, intravenousdrug abuse, and anaemia57.6%< 6 hours1386Li 2010 73 Multicentre, China Mean age 64, 163 (72%) male Chest pain for > 30 minutesand < 12 hours, suspected ofMINo other criteria reported 4 (median) 227McCann 2008 76 Multicentre, NorthernIrelandMean age 63, 281 (68%) male Ischaemic-type chest painwithin 24 hoursAge < 18 years, interhospitaltransfer, and previous participationin the study5.3 (median) 415Naroo 2009 78 Single centre, UnitedArab EmiratesAge not reported, 627 (79%)maleTypical chest pain within12 hoursSTEMI, known renal disease NR 791Reichlin 2009 19 Multicentre, international Median age 64, 471 (66%)maleChest pain within 12 hours Terminal kidney failure requiringdialysisNR 718Valle 2008 82 Multicentre, Spain Mean age 65, 287 (68%) male Suspected ACS with symptomsbetween 20 minutes and180 minutes of presentationNo other criteria reported 1.2 (mean) 41922NIHR Journals Library