Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Study Study typePopulation: age (years) andsex Inclusion criteria Exclusion criteriaTime fromsymptoms(hours)No. ofpatientsGuo 2006 66 Single centre, China Median age 72,237(47%) maleChest pain within 0.5–24 hours NR 4 (median) 502Ilva 2009 50 Single centre, Finland Mean age 67, 181 (62%) male Chest pain suggestingmyocardial ischaemiaUncertain or > 24-hour delay fromsymptom onset4.7 (median) 293Keating 2006 70 Multicentre, UK Median age 61, 251/399eligible (63%) malePossible ischaemic cardiac chestpain and normal ECGPain for > 8 hours on admission,pain ceased > 2 hours previously,pregnant, renal replacementtherapy, jaundiceNot stated 277Keller 2009 20 Multicentre, Germany Mean age 61, 1208 (66.4%)maleNew-onset chest painpresenting at chest pain unitMajor surgery or trauma withinthe previous 4 weeks, pregnancy,obvious intravenous drug abuse andanaemia with haemoglobin level of< 10 g/dl59.5%< 6 hours1818LeFevre 2007 72 Multicentre, France Mean age 61, 71/100 male Not specified Not specified 5.9 (median) 75Liao 2009 74 Single centre, China Mean age 69, 54 (73%) male Chest pain and/or dyspnoealasting for at least 20 minuteswithin the last 3 hoursNone reported 2.2 (median) 74Mion 2007 77 Single centre, Italy Mean age 63, 88 (67%) male Non-consecutive patients withchest painNone reported 3.8 (median) 132Reichlin 2009 19 Multicentre, international Median age 64471 (66%) maleChest pain within 12 hours Terminal kidney failure requiringdialysisNR 718Rudolph 2010 81 Single centre, Germany Mean age 64, 192 (70%) male Chest pain presenting to the ED NR 4.5 (median) 274AMI, acute myocardial infarction; LBBB, left bundle branch block; NR, not reported.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.21