Systematic review, meta-analysis and economic modelling of ...

More documents

Recommendations

Info

Assessment of diagnostic and prognostic accuracyTABLE 3 Population characteristics of studies of TnIStudy Study typePopulation: age (years) andsex Inclusion criteria Exclusion criteriaTime fromsymptoms(hours)No. ofpatientsAmodio 2007 52 Single centre, Italy Mean age 61, 308 (60%) male Chest pain with suspectedclinical angina or AMISTEMI, new-onset LBBB 5.0 (median) 516Apple 2008 53 Multicentre, USA andFranceNR Symptoms suggestive of ACS NR NR 545Apple 2008 54 Single centre, USA Mean age 57, 223 (60%) male Symptoms indicative of ACS NR 5.1 (median) 371Apple 2009 55 Single centre, USA Mean age 54, 260 (57%) male Symptoms suggestive of ACSwithin 12 hoursNR 3.1 (median) 457Bassan 2005 56 Single centre, Brazil Mean age 67, 343 male Chest pain < 12 hours due topossible acute cardiac ischaemiaST segment elevation 2.0 (median) 631Body 2011 57 Single centre, UK Mean age 59, 430 (61%) male Suspected cardiac chest painoccurring within the previous24 hoursChest trauma, renal failurerequiring dialysis, medical conditionnecessitating admission, pregnancy3.5 (median) 705Charpentier Single centre, France Mean age 57, 454 (67%) male Chest pain due to suspected2010 59 within 12 hoursST elevation, traumatic cause,previous severe renal impairment orsevere communication problems2.9 (median) 677Collinson 2006 62 Multicentre, UK Median age 60, 150 (70%)maleChest pain due to suspectedACS within 24 hoursSTEMI 3 (median) 213Collinson 2006 48 Single centre, UK Median age 52, 335 (62%)maleUndifferentiated chest pain ECG changes of ACS, unstableangina, comorbidity requiringadmission, clearly non-cardiac pain6 (median) 539Di Serio 2005 63 Single centre, Italy Mean age: female 79, male 65;23 (77%) maleNot specified ST elevation 3.4 (mean) 30Ecollan 2007 64 Mobile units, France Mean age 68, 68 (63%) male Consecutive emergencies withchest painPatients with cardiogenic shock orthose with any evidence of a recentchest trauma2.3 (median) 108Garcia-Valdecasas Single centre, France Mean age 67, 114 (69%) male Chest pain > 20 minutes‘2011 49 duration within 6 hoursChest trauma NR 16520NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Study Study typePopulation: age (years) andsex Inclusion criteria Exclusion criteriaTime fromsymptoms(hours)No. ofpatientsGuo 2006 66 Single centre, China Median age 72,237(47%) maleChest pain within 0.5–24 hours NR 4 (median) 502Ilva 2009 50 Single centre, Finland Mean age 67, 181 (62%) male Chest pain suggestingmyocardial ischaemiaUncertain or > 24-hour delay fromsymptom onset4.7 (median) 293Keating 2006 70 Multicentre, UK Median age 61, 251/399eligible (63%) malePossible ischaemic cardiac chestpain and normal ECGPain for > 8 hours on admission,pain ceased > 2 hours previously,pregnant, renal replacementtherapy, jaundiceNot stated 277Keller 2009 20 Multicentre, Germany Mean age 61, 1208 (66.4%)maleNew-onset chest painpresenting at chest pain unitMajor surgery or trauma withinthe previous 4 weeks, pregnancy,obvious intravenous drug abuse andanaemia with haemoglobin level of< 10 g/dl59.5%< 6 hours1818LeFevre 2007 72 Multicentre, France Mean age 61, 71/100 male Not specified Not specified 5.9 (median) 75Liao 2009 74 Single centre, China Mean age 69, 54 (73%) male Chest pain and/or dyspnoealasting for at least 20 minuteswithin the last 3 hoursNone reported 2.2 (median) 74Mion 2007 77 Single centre, Italy Mean age 63, 88 (67%) male Non-consecutive patients withchest painNone reported 3.8 (median) 132Reichlin 2009 19 Multicentre, international Median age 64471 (66%) maleChest pain within 12 hours Terminal kidney failure requiringdialysisNR 718Rudolph 2010 81 Single centre, Germany Mean age 64, 192 (70%) male Chest pain presenting to the ED NR 4.5 (median) 274AMI, acute myocardial infarction; LBBB, left bundle branch block; NR, not reported.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.21
Page 1: Health Technology AssessmentVOLUME
Page 7: DOI: 10.3310/hta17010 Health Techno
Page 10 and 11: ContentsAppendix 5 Expected discoun
Page 13 and 14: DOI: 10.3310/hta17010 Health Techno
Page 19: DOI: 10.3310/hta17010 Health Techno
Page 22 and 23: BackgroundTABLE 1 Hospital admissio
Page 24 and 25: Background2. investigation of the c
Page 26 and 27: BackgroundComputed tomographic coro
Page 28 and 29: Research questionsiii. the diagnost
Page 30 and 31: Assessment of diagnostic and progno
Page 91 and 92:
DOI: 10.3310/hta17010 Health Techno
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125:
Page 128 and 129:
Discussionspecificity were 62% (95%
Page 130 and 131:
Discussionneed for revascularisatio
Page 132 and 133:
Discussionchanges in sensitivity an
Page 134 and 135:
Discussionuncertainty about these p
Page 136 and 137:
Discussiontroponin assays have bett
Page 138 and 139:
ConclusionsSuggested research prior
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151:
Page 154 and 155:
Appendix 144. heart-type fatty acid
Page 156 and 157:
Appendix 1135. interleukin 33.mp. (
Page 158 and 159:
Appendix 147. 37 and 45 (529)48. li
Page 161:
Page 164 and 165:
Appendix 313. Fernandez Portales JG
Page 166 and 167:
Appendix 346. Luscher MS, Ravkilde
Page 168 and 169:
Appendix 316. Rao SV, Ohman EM, Gra
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195:
Page 198 and 199:
Appendix 9Clinical diagnosis of NST
Page 200 and 201:
Appendix 9respectively. Exercise EC
Page 202 and 203:
Appendix 93. Two reviewers will mak
Page 204 and 205:
Appendix 9The methodology used in t
Page 206 and 207:
Appendix 9ES (Information Resources
Page 208:
Appendix 923. Westwood ME, Whiting
show all

Systematic review, meta-analysis and economic modelling of ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?