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Appendix 414. Coles DR, Wilde P, Rogers C, Oberhoff M, Karsch KR, Baumbach A. Diagnostic accuracy of noninvasivecoronary angiography with multislice computed tomography in patients presenting withacute chest pain. Heart 2005;91:A15–16.15. Cox JL, Teskey RJ, Lalonde LD, Iles SE. Noninvasive Testing in Women Presenting with Chest Pain –Evidence for Diagnostic Uncertainty. Can J Cardiol 1995;11:885–90.16. Davin LL. Diagnostic accuracy of computed tomography coronary angiography in routine practice.Acta Cardiol 2007;62:339–44.17. Devine PJ, V. Real-world application of coronary computed tomography angiography and itspotential effect on downstream resource utilization in evaluating angina. J Cardiovasc ComputTomogr 2008;2:214–19.18. Feldman CL, MacCallum G, Hartley LH. Comparison of the standard ECG with the EASIcardiogram(c) for ischemia detection during exercise monitoring. Conference Proceeding. Brigham andWomen’s Hospital, Boston, MA, October 1997. DOI:10.1109/CIC.1997.647903.19. Flukinger T, White CS. Multidetector computed tomography in the evaluation of chest pain in theemergency department. Semin Roentgenol 2008;43:136–44.20. Gallagher MJR. The diagnostic accuracy of 64-Slice computed tomography coronary angiographycompared with stress nuclear imaging in emergency department low-risk chest pain patients. AnnEmerg Med 2007;49:125–36.21. Geluk CA, Dikkers R, Perik PJ, Tio RA, Götte MJ, Hillege HL, et al. Measurement of coronary calciumscores by electron beam computed tomography or exercise testing as initial diagnostic tool in lowriskpatients with suspected coronary artery disease. Eur Radiol 2008;18:244–52.22. Georgiou D, Budoff MJ, Kaufer E, Kennedy JM, Lu B, Brundage BH. Screening patients with chestpain in the emergency department using electron beam tomography: a follow-up study. J Am CollCardiol 2001;38:105–10.23. Halpern EJ, Levin DC, Zhang S, Takakuwa KM, Halpern EJ, Levin DC, et al. Comparison of imagequality and arterial enhancement with a dedicated coronary CTA protocol versus a triple rule-outcoronary CTA protocol. Acad Radiol 2009;16:1039–48.24. Hansen MG. The value of dual-source 64-slice CT coronary angiography in the assessment ofpatients presenting to an acute chest pain service. Heart Lung Circ 2010;19:213–18.25. Hendel RC, Hendel RC. Is computed tomography coronary angiography the most accurate andeffective noninvasive imaging tool to evaluate patients with acute chest pain in the emergencydepartment? CT coronary angiography is the most accurate and effective noninvasive imagingtool for evaluating patients presenting with chest pain to the emergency department: antagonistviewpoint. Circ Cardiovasc Imaging 2009;2:264–75.26. Hermann LK, Weingart SD, Duvall WL, Henzlova MJ. The limited utility of routine cardiac stresstesting in emergency department chest pain patients younger than 40 years. Ann Emerg Med2009;54:12–16.27. Hoffmann U, Bamberg F, Chae CU, Nichols JH, Rogers IS, Seneviratne SK, et al. Coronary computedtomography angiography for early triage of patients with acute chest pain: the ROMICAT(Rule Out Myocardial Infarction using Computer Assisted Tomography) trial. J Am Coll Cardiol2009;53:1642–50.28. Hoffmann U, Nagurney JT, Moselewski F, Pena A, Ferencik M, Chae CU, et al. Coronary multidetectorcomputed tomography in the assessment of patients with acute chest pain. Circ Cardiovasc Imaging2006;114:2251–60.152NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 129. Hoffmann U, Bamberg F. CT Coronary angiography is the most accurate and effective noninvasiveimaging tool for evaluating patients presenting with chest pain to the emergency department. CircCardiovascr Imaging 2009;2:251–63.30. Hollander JE, Litt HI, Chase M, Brown AM, Kim W, Baxt WG, et al. Computed tomography coronaryangiography for rapid disposition of low-risk emergency department patients with chest painsyndromes. Acad Emerg Med 2007;14:112–16.31. Huber S, Huber M, Dees D, Redmond FA, Wilson JM, Flamm SD. Usefulness of multislice spiralcomputed tomography coronary angiography in patients with acute chest pain in the emergencydepartment. J Cardiovasc Comput Tomogr 2007;1:29–37.32. Jeetley P, Burden L, Stoykova B, Senior R, Jeetley P, Burden L, et al. Clinical and economic impact ofstress echocardiography compared with exercise electrocardiography in patients with suspectedacute coronary syndrome but negative troponin: a prospective randomized controlled study. EurHeart J 2007;28:204–11.33. Jeetley P, Burden L, Greaves K, Senior R, Jeetley P, Burden L, et al. Prognostic value of myocardialcontrast echocardiography in patients presenting to hospital with acute chest pain and negativetroponin. Am J Cardiol 2007;99:1369–73.34. Jeetley PB. Stress echocardiography is superior to exercise ECG in the risk stratification of patientspresenting with acute chest pain with negative Troponin. Eur J Echocardiogr 2006;7:155–64.35. Jelinkova AH. New indexes in the diagnostics of coronary artery disease in females by means ofexercise ECG. Scripta Medica 1997;70:45–50.36. Johnson TRC, Nikolaou K, Becker A, Leber AW, Rist C, Wintersperger BJ, et al. Dual-source CT forchest pain assessment. Eur Radiol 2008;18:773–80.37. Johnson TRC, Nikolaou K, Fink C, Becker A, Knez A, Rist C, et al. Dual-source CT in chest paindiagnosis. Radiologe 2007;47:301–9.38. Khare R, Lee T, Powell E, Courtney D. Cost effectiveness of CT coronary angiography compared toother strategies for evaluating chest pain in patients in the emergency department. Proceedingsof the 2007 Society for Academic Emergency Medicine Annual Meeting. Acad Emerg Med2007;14:S37–8.39. Khare RK, Courtney DM, Powell ES, Venkatesh AK, Lee TA. Sixty-four-slice computed tomographyof the coronary arteries: cost-effectiveness analysis of patients presenting to the emergencydepartment with low-risk chest pain. Acad Emerg Med 2008;15:623–32.40. Kim JL. Efficacy and safety of the computed tomography coronary angiography based approach forpatients with acute chest pain at an emergency department: one month clinical follow-up study. JKorean Med Sci 2010;25:466–71.41. Kuntz KMF. Cost-effectiveness of diagnostic strategies for patients with chest pain. Ann Intern Med1999;130:709–18.42. Langer C, Wiemer M, Peterschroder A, Franzke K, Mellwig KP, van Buuren F, et al. Stratificationfor noninvasive coronary angiography: patient preselection considering atypical angina pectoris,conventional cardiovascular risk assessment, and calcium scoring. Eur J Cardiovasc Prev Rehabil2009;16:201–9.43. Lau J, Ioannidis JP, Balk E, Milch C, Chew P, Terrin N, et al. Evaluation of technologies for identifyingacute cardiac ischemia in emergency departments. AHRQ 2001;315.44. Laudon DA, Vukov LF, Breen JF, Rumberger JA, Wollan PC, Sheedy PF, II. Use of electron-beamcomputed tomography in the evaluation of chest pain patients in the emergency department. AnnEmerg Med 1999;33:15–21.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.153
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Health Technology AssessmentVOLUME
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DOI: 10.3310/hta17010 Health Techno
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ContentsAppendix 5 Expected discoun
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BackgroundTABLE 1 Hospital admissio
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Background2. investigation of the c
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BackgroundComputed tomographic coro
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Research questionsiii. the diagnost
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Assessment of diagnostic and progno
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Page 128 and 129: Discussionspecificity were 62% (95%
Page 130 and 131: Discussionneed for revascularisatio
Page 132 and 133: Discussionchanges in sensitivity an
Page 134 and 135: Discussionuncertainty about these p
Page 136 and 137: Discussiontroponin assays have bett
Page 138 and 139: ConclusionsSuggested research prior
Page 154 and 155: Appendix 144. heart-type fatty acid
Page 156 and 157: Appendix 1135. interleukin 33.mp. (
Page 158 and 159: Appendix 147. 37 and 45 (529)48. li
Page 164 and 165: Appendix 313. Fernandez Portales JG
Page 166 and 167: Appendix 346. Luscher MS, Ravkilde
Page 168 and 169: Appendix 316. Rao SV, Ohman EM, Gra
Page 198 and 199: Appendix 9Clinical diagnosis of NST
Page 200 and 201: Appendix 9respectively. Exercise EC
Page 202 and 203: Appendix 93. Two reviewers will mak
Page 204 and 205: Appendix 9The methodology used in t
Page 206 and 207: Appendix 9ES (Information Resources
Page 208: Appendix 923. Westwood ME, Whiting
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