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Appendix 316. Rao SV, Ohman EM, Granger CB, Armstrong PW, Gibler WB, Christenson RH, et al. Prognosticvalue of isolated troponin elevation across the spectrum of chest pain syndromes. Am J Cardiol2003;91:936–40.17. Solymoss BC, Bourassa MG, Fortier A, roux P, Solymoss BC, Bourassa MG, et al. Evaluation and riskstratification of acute coronary syndromes using a low cut-off level of cardiac troponin T, combinedwith CK-MB mass determination. Clin Biochem 2004;37:286–92.18. Wilcox G, Archer PD, Bailey M, Dziukas L, Lim CF, Schneider HG, et al. Measurement of cardiactroponin I levels in the emergency department: predictive value for cardiac and all-cause mortality.Med J Aust 2001;174:170–3.Wrong outcomes for this review (n = 5)1. Kurata AW. Clinical usefulness of heart-type fatty acid binding protein as an early marker ofmyocardial damage. Jpn J Interv Cardiol 2003;18:463–9.2. Liyan C, Jie Z, Xiaozhou H. Prognostic value of combination of heart-type fatty acid-binding proteinand ischemia-modified albumin in patients with acute coronary syndromes and normal troponin Tvalues. J Clin Lab Anal 2009;23:14–18.3. Lozano T, Ena J, Almenar V, Graells M, Molina J, Antorrena I, et al. Evaluation of patients with acutechest pain of uncertain origin by means of serial measurements high-sensitivity C-reactive protein.Rev Esp Cardiol 2007;60:817–24.4. Ruzgar O, Bilge AK, Bugra Z, Umman S, Yilmaz E, Ozben B, et al. The use of human heart-type fattyacid-binding protein as an early diagnostic biochemical marker of myocardial necrosis in patientswith acute coronary syndrome, and its comparison with troponin-T and creatine kinase-myocardialband. Heart Ves 2006;21:309–14.5. Sypniewska GS. The use of biochip cardiac array technology for early diagnosis of acute coronarysyndromes. J Med Biochem 2009;28:293–9.Not available (n = 4)1. Ellenius J, Groth T, Lindahl B, Ellenius J, Groth T, Lindahl B. Neural network analysis of biochemicalmarkers for early assessment of acute myocardial infarction. Stud Health Technol Inform1997;43:382–5.2. Higuchi K, Abe S, Matsuoka T, Nakajima H, Toda H, Akazaki Y, et al. [Usefulness of rapid quantitativecardiac troponin T and myoglobin assays for the diagnosis of acute myocardial infarction.] J Cardiol2003;41:55–62.3. Ogawa M, Abe S, Saigo M, Kozono T, Yamaguchi K, Toda H, et al. [Usefulness of rapidbedside cardiac troponin T assay for the diagnosis of acute myocardial infarction.] J Cardiol2000;35:157–64.4. Viggiano MS. Prehospital diagnosis and direction of patients suspected of acute coronarysyndrome. Feasibility of the combined evaluation of a single blood sample value of cardiactroponin-I, myoglobin, and creatine phosphokinase MB. JEUR 2000;13:229–34.148NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Issues with timing of index and reference tests (n = 4)1. Collinson PO, Gaze DC, Morris F, Morris B, Price A, Goodacre S, et al. Comparison of biomarkerstrategies for rapid rule out of myocardial infarction in the emergency department using ACC/ESCdiagnostic criteria. Ann Clin Biochem 2006;43:273–80.2. Goodacre S, Locker T, Arnold J, Angelin K, Morris F. Which diagnostic tests are most useful in achest pain unit protocol? BMC Emerg Med 2005;5:6.3. Januzzi JL, Bamberg F, Lee H, Truong QA, Nichols JH, Karakas M, et al. High-sensitivity troponinT concentrations in acute chest pain patients evaluated with cardiac computed tomography.Circulation 2010;121:1227–34.4. Kavsak PA, MacRae AR, Lustig V, Bhargava R, Vandersluis R, Palomaki GE, et al. The impact of theESC/ACC redefinition of myocardial infarction and new sensitive troponin assays on the frequency ofacute myocardial infarction. Am Heart J 2006;152:118–25.Less than 80% of sample received tests (n = 1)1. Straface AL, Myers JH, Kirchick HJ, Blick KE, Straface AL, Myers JH, et al. A rapid point-of-carecardiac marker testing strategy facilitates the rapid diagnosis and management of chest painpatients in the emergency department. Am J Clin Pathol 2008;129:788–95.Language issues (n = 1)1. Rembek M, Goch A, Chizynski K, Goch JH, Rembek M, Goch A, et al. [Estimation of clinical reliabilityand diagnostic usefulness of human fatty acid-binding protein in acute coronary syndromes.] PolMerkuriusz Lek 2006;21:418–22.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.149
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ContentsAppendix 5 Expected discoun
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BackgroundTABLE 1 Hospital admissio
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Background2. investigation of the c
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BackgroundComputed tomographic coro
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Research questionsiii. the diagnost
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Assessment of diagnostic and progno
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Page 128 and 129: Discussionspecificity were 62% (95%
Page 130 and 131: Discussionneed for revascularisatio
Page 132 and 133: Discussionchanges in sensitivity an
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Page 136 and 137: Discussiontroponin assays have bett
Page 138 and 139: ConclusionsSuggested research prior
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Page 156 and 157: Appendix 1135. interleukin 33.mp. (
Page 158 and 159: Appendix 147. 37 and 45 (529)48. li
Page 164 and 165: Appendix 313. Fernandez Portales JG
Page 166 and 167: Appendix 346. Luscher MS, Ravkilde
Page 198 and 199: Appendix 9Clinical diagnosis of NST
Page 200 and 201: Appendix 9respectively. Exercise EC
Page 202 and 203: Appendix 93. Two reviewers will mak
Page 204 and 205: Appendix 9The methodology used in t
Page 206 and 207: Appendix 9ES (Information Resources
Page 208: Appendix 923. Westwood ME, Whiting
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