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Appendix 346. Luscher MS, Ravkilde J, Thygesen K, scher MS, Ravkilde J, Thygesen K. Clinical application of twonovel rapid bedside tests for the detection of cardiac troponin T and creatine kinase-MB mass/myoglobin in whole blood in acute myocardial infarction. Cardiology 1998;89:222–8.47. Schuchert A, Hamm C, Scholz J, Klimmeck S, Goldmann B, Meinertz T, et al. Prehospital testing fortroponin T in patients with suspected acute myocardial infarction. Am Heart J 1999;138:45–8.48. Seino Y, Tomita Y, Takano T, Ohbayashi K, Tokyo Rapid-Test Office Cardiologists (Tokyo-ROC) Study,Seino Y, et al. Office cardiologists cooperative study on whole blood rapid panel tests in patientswith suspicious acute myocardial infarction: comparison between heart-type fatty acid-bindingprotein and troponin T tests. Circ J 2004;68:144–8.49. Seino Y, Ogata K, Takano T, Ishii J, Hishida H, Morita H, et al. Use of a whole blood rapid panel testfor heart-type fatty acid-binding protein in patients with acute chest pain: comparison with rapidtroponin T and myoglobin tests. Am J Med 2003;115:185–90.50. Sobki SH, Saadeddin SM, Habbab MA, Sobki SH, Saadeddin SM, Habbab MA. Cardiac markers usedin the detection of myocardial injury. Saudi Med J 2000;21:843–6.51. Stokke M, Gronvold T, Siebke AM, Skjaeggestad O, Stromme JH, Stokke M, et al. Serialmeasurements of cardiac markers to rule in or out acute myocardial damage less than 3 h afteradmission in acute chest pain patients without ECG-signs of acute myocardial infarction. Scand JClin Lab Invest 1998;58:331–8.52. Stork TG. Suspected acute coronary syndrome in patients without ST-segment elevation: Rule-outinfarction, value of clinical decision-making and non-coronary diagnoses. Dtsch Med Wochenschr2002;127:260–5.53. Stork TV, Wu AHB, Muller-Bardorff M, Gareis R, Muller R, Hombach V, et al. Diagnostic andprognostic role of myoglobin in patients with suspected acute coronary syndrome. Am J Cardiol2000;86:1371.54. Suzuki M, Hori S, Fujishima S, Takatsuki S, Nakamura I, Kimura H, et al. Diagnostic value of abedside test for cardiac troponin T in the patient with chest pain presenting to the emergencyroom. Keio J Med 2000;49:74–9.55. Walter S, Carlsson J, Cuneo A, Tebbe U, Walter S, Carlsson J, et al. [Leading symptoms of chestpain in the emergency room. Using cardiac markers for risk stratification.] Dtsch Med Wochenschr2001;126:771–8.56. Zarich S, Bradley K, Seymour J, Ghali W, Traboulsi A, Mayall ID, et al. Impact of troponin Tdeterminations on hospital resource utilization and costs in the evaluation of patients withsuspected myocardial ischemia. Am J Cardiol 2001;88:732–6.57. Zarich SW, Qamar AU, Werdmann MJ, Lizak LS, McPherson CA, Bernstein LH, et al. Value of a singletroponin T at the time of presentation as compared to serial CK-MB determinations in patients withsuspected myocardial ischemia. Clin Chim Acta 2002;326:185–92.58. Zhang PZ. A comparison of different combination regimens of biochemical markers in diagnosingacute myocardial infarction. Chin J Evid-Based Med 2006;6:777–82.59. Zimmerman J, Fromm R, Meyer D, Boudreaux A, Wun CC, Smalling R, et al. Diagnostic markercooperative study for the diagnosis of myocardial infarction. Circulation 1999;99:1671–7.146NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Prognosis-only studies that analyse only troponin and/or creatine kinaseMB isoenzyme as variables (n = 18)1. Christ M, Popp S, et al. Implementation of High Sensitivity Cardiac Troponin T Measurement in theEmergency Department. Am J Med 2010;123:1134–42.2. deFilippi CR, Tocchi M, Parmar RJ, Rosanio S, Abreo G, Potter MA, et al. Cardiac troponin T in chestpain unit patients without ischemic electrocardiographic changes: angiographic correlates andlong-term clinical outcomes. J Am Coll Cardiol 2000;35:1827–34.3. deFilippi CR, Parmar RJ, Potter MA, Tocchi M, deFilippi CR, Parmar RJ, et al. Diagnostic accuracy,angiographic correlates and long-term risk stratification with the troponin T ultra sensitive RapidAssay in chest pain patients at low risk for acute myocardial infarction. Eur Heart J 1998;(Suppl.19):42–7.4. Goodacre S, Locker T. Which diagnostic tests are most useful in a chest pain unit protocol? BMCEmerg Med 2005;5:6.5. Herkner H, Waldenhofer U, Laggner AN, llner M, Oschatz E, Spitzauer S, et al. Clinical applicationof rapid quantitative determination of cardiac troponin-T in an emergency department setting.Resuscitation 2001;49:259–64.6. Kontos MC, Shah R, Fritz LM, Anderson FP, Tatum JL, Ornato JP, et al. Implication of different cardiactroponin I levels for clinical outcomes and prognosis of acute chest pain patients. J Am Coll Cardiol2004;43:958–65.7. Kontos MCA. Ability of troponin I to predict cardiac events in patients admitted from theemergency department. J Am Coll Cardiol 2000;36:1818–23.8. Koukkunen H, Penttil K, Kemppainen A, Penttil I, et al. Ruling out myocardial infarction withtroponin T and creatine kinase MB mass: diagnostic and prognostic aspects. Scand Cardiovasc J2001;35:302–6.9. Limkakeng A, Jr, Gibler WB, Pollack C, Hoekstra JW, Sites F, Shofer FS, et al. Combination ofGoldman risk and initial cardiac troponin I for emergency department chest pain patient riskstratification. Acad Emerg Med 2001;8:696–702.10. Meyer T, Binder L, Graeber T, Luthe H, Kreuzer H, Oellerich M, et al. Superiority of combined CK-MBand troponin I measurements for the early risk stratification of unselected patients presenting withacute chest pain. Cardiology 1998;90:286–94.11. Mills NL. Implementation of a sensitive troponin i assay and risk of recurrent myocardial infarctionand death in patients with suspected acute coronary syndrome. JAMA 2011;305:1210–16.12. Muscholl MW, Oswald M, Mayer C, von SW, Muscholl MW, Oswald M, et al. Prognostic value of2D echocardiography in patients presenting with acute chest pain and non-diagnostic ECG forST-elevation myocardial infarction. Int J Cardiol 2002;84:217–25.13. Newby LK, Kaplan AL, Granger BB, Sedor F, Califf RM, Ohman EM. Comparison of cardiac troponinT versus creatine kinase-MB for risk stratification in a chest pain evaluation unit. Am J Cardiol2000;85:801–5.14. Noeller TP, Meldon SW, Peacock WF, Emerman CL, McErlean ES, Vanlente F, et al. Troponin T inelders with suspected acute coronary syndromes. Am J Emerg Med 2003;21:293–7.15. Peacock WF IV, Emerman CL, McErlean ES, Deluca SA, Van LF, Rao JS, et al. Prediction of shortandlong-term outcomes by troponin T levels in low-risk patients evaluated for acute coronarysyndromes. Ann Emerg Med 2000;35:213–20.© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.147
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Health Technology AssessmentVOLUME
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ContentsAppendix 5 Expected discoun
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BackgroundTABLE 1 Hospital admissio
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Background2. investigation of the c
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BackgroundComputed tomographic coro
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Research questionsiii. the diagnost
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Assessment of diagnostic and progno
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Page 128 and 129: Discussionspecificity were 62% (95%
Page 130 and 131: Discussionneed for revascularisatio
Page 132 and 133: Discussionchanges in sensitivity an
Page 134 and 135: Discussionuncertainty about these p
Page 136 and 137: Discussiontroponin assays have bett
Page 138 and 139: ConclusionsSuggested research prior
Page 154 and 155: Appendix 144. heart-type fatty acid
Page 156 and 157: Appendix 1135. interleukin 33.mp. (
Page 158 and 159: Appendix 147. 37 and 45 (529)48. li
Page 164 and 165: Appendix 313. Fernandez Portales JG
Page 168 and 169: Appendix 316. Rao SV, Ohman EM, Gra
Page 198 and 199: Appendix 9Clinical diagnosis of NST
Page 200 and 201: Appendix 9respectively. Exercise EC
Page 202 and 203: Appendix 93. Two reviewers will mak
Page 204 and 205: Appendix 9The methodology used in t
Page 206 and 207: Appendix 9ES (Information Resources
Page 208: Appendix 923. Westwood ME, Whiting
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