Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Appendix 2 Methodology checklist: the modifiedQUADAS tool for studies of diagnostic test accuracyChecklist completed by:Circle one option for each questionWas the spectrum of participants representative of the patients who willreceive the test in practice? (i.e. patients presenting to the emergency servicesor department with chest pain and suspected ACS)Was the reference standard likely to classify the target condition correctly? (i.e.was it based on the universal definition of MI?)Was the period between performance of the reference standard and the indextest short enough to be reasonably sure that the target condition did notchange between the two tests? (i.e. were the two tests both conducted withinthe 12-hour time frame required for the reference standard?)Did the whole sample or a random selection of the sample receive verificationusing the reference standard?Did participants receive the same reference standard regardless of the indextest result?Was the reference standard independent of the index test? (i.e. the index testdid not form part of the reference standard)Were the index test results interpreted without knowledge of the results of thereference standard?Were the reference standard results interpreted without knowledge of theresults of the index test?Yes No Unclear N/AYes No Unclear N/AYes No Unclear N/AYes No Unclear N/AYes No Unclear N/AYes No Unclear N/AYes No Unclear N/AYes No Unclear N/AWere uninterpretable, indeterminate or intermediate test results reported? a Yes No Unclear N/AN/A, not applicable.a This criterion was included in the quality assessment of the CTCA/ETT studies, as there was a risk of uninterpretableresults from imaging in this review, which did not apply to the biomarkers review.Adapted from Whiting et al. 28© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.141