Systematic review, meta-analysis and economic modelling of ...

DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 13. chest-pain.mp. (21,868)4. (cardiac adj pain).mp. (359)5. (thora* adj pain).mp. (1021)6. Acute Coronary Syndrome/ (3225)7. acute coronary syndrome.mp. (7796)8. (acute adj coronary adj syndrome).mp. (7796)9. Angina, Unstable/ (7731)10. unstable angina.mp. (9938)11. (unstable adj2 angina).mp. (13,062)12. Myocardial Infarction/ (126,097)13. myocardial.mp. (307,231)14. infarct*.mp. (222,416)15. (myocardial adj infarction).mp. (163,611)16. heart attack.mp. (2541)17. (heart adj (arrest$or attack*)).mp. (29,168)18. (preinfarction or pre-infarction or (pre adj infarction)).mp. (408)19. or/1–18 (417,635)Coronary computed tomography angiography terms20. Coronary computed tomography angiography.mp. (132)21. CCTA.mp. (152)22. ((CT or comput$tomog$) adj3 coronary angiogra$).mp. (992)23. ((electrocard$or ecg) adj2 exercise).mp. [mp=title, original title, abstract, name of substance word,subject heading word, unique identifier] (2885)24. (treadmill or stress or exercise adj2 test).tw25. 20 or 21 or 22 or 23 (4104)Comparator terms26. coronary angiography/ (40,511)27. coronary angiogra$.mp. (49,249)28. reference standards/ (27,529)29. reference standard$.mp. (32,859)30. gold standard.mp. (22,845)31. Major adverse event*.mp. (805)32. (major cardiac adj events).mp. (497)33. or/25–31 (105,094)34. 24 and 33 (2029)Human-only studies35. human/ (11,609,245)36. animal/ (4,746,107)37. 34 not (35 and 34) (10,378,871)38. 19 and 24 and 33 and 36 (1066)Diagnostics filter39. exp “Sensitivity and Specificity”/ (327,472)40. sensitivity.tw. (425,433)41. specificity.tw. (267,723)42. ((pre-test or pretest) adj probability).tw. (932)43. post-test probability.tw. (258)44. predictive value$.tw. (52,099)45. likelihood ratio$.tw. (6262)46. 38 or 39 or 40 or 41 or 42 or 43 or 44 (834,065)© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.137