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Appendix 144. heart-type fatty acid binding protein.mp. (196)45. H-FABP.mp. (312)46. (co-peptin or co?peptin or copeptin).mp. (116)47. adrenomedullin.mp. or Adrenomedullin/ (2412)48. ST-2.mp. (181)49. interleukin 33.mp. (104)50. galectin 3.mp. or Galectin 3/ (1455)51. Matrix Metalloproteinase 9/or matrix metalloproteinase 9.mp. (10,074)52. pregnancy-associated plasma protein.mp. (1164)53. pregnancy associated plasma protein A.mp. (1145)54. PAPP-A.mp. (853)55. Ischaemia Modified Albumin.mp. (38)56. early troponin.mp. (7)57. troponin at presentation.mp. (0)58. initial troponin.mp. (18)59. or/20–58 (114,505)Troponin and reference standard terms60. Troponin T/or Troponin I/ (6449)61. (troponin T or troponin I).mp. (9156)62. cardiac troponin T.mp. (1573)63. cardiac troponin I.mp. (2114)64. ctnt.mp. (986)65. reference standards/ (27,529)66. reference standard$.mp. (32,855)67. gold standard.mp. (22,828)68. Major adverse event*.mp. (803)69. (major cardiac adj events).mp. (497)70. or/60–69 (65,727)Human-only studies71. human/ (11,609,100)72. animal/ (4,746,079)73. 71 not (71 and 72) (10,378,731)74. 19 and 59 and 70 and 73 (2306)75. exp “Sensitivity and Specificity”/ (327,463)76. sensitivity.tw. (425,187)77. specificity.tw. (267,581)78. ((pre-test or pretest) adj probability).tw. (932)79. post-test probability.tw. (258)80. predictive value$.tw. (52,063)81. likelihood ratio$.tw. (6258)82. or/75–81 (833,726)83. 74 and 82 (974)Not case–control studies84. Case-Control Studies/ (131,351)85. 83 not 84 (947)Date limit86. limit 85 to yr=“1995 -Current” (911)134NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 1Biomarkers review prognostic accuracy search: a MEDLINE exampleChest pain population terms87. exp Chest Pain/ (43,381)88. (chest adj (pain or discomfort or tight* or pressure)).mp. (23,091)89. chest-pain.mp. (21,852)90. (cardiac adj pain).mp. (359)91. (thora* adj pain).mp. (1021)92. Acute Coronary Syndrome/ (3223)93. acute coronary syndrome.mp. (7783)94. (acute adj coronary adj syndrome).mp. (7783)95. Angina, Unstable/ (7731)96. unstable angina.mp. (9934)97. (unstable adj2 angina).mp. (13,058)98. Myocardial Infarction/ (126,095)99. myocardial.mp. (307,141)100. infarct*.mp. (222,338)101. (myocardial adj infarction).mp. (163,555)102. heart attack.mp. (2540)103. (heart adj (arrest$or attack*)).mp. (29,166)104. (preinfarction or pre-infarction or (pre adj infarction)).mp. (408)105. or/1–18 (417,505)Biomarker terms106. creatine kinase.mp. or Creatine Kinase/ (27,627)107. ((creatine adj kinase) or (creatine adj phosphokinase)).mp. (29,176)108. creatine kinase MB.mp. (2589)109. creatine kinase MB isoenzyme.mp. (288)110. creatine kinase isoenzyme 2.mp. (8)111. creatine kinase 2.mp. (40)112. CK-2.mp. (161)113. CK-MB.mp. (2903)114. myoglobin.mp. or Myoglobin/ (11,827)115. C-Reactive Protein/ (22,195)116. (c-reactive protein or c reactive protein).mp. (33,427)117. CRP.mp. (18,869)118. myeloperoxidase.mp. (12,827)119. mpo.mp. (6279)120. b-type natriuretic peptide.mp. (2624)121. type b natriuretic peptide.mp. (47)122. Natriuretic Peptides/ (847)123. (brain adj natriuretic peptide).mp. (5237)124. N terminal B type natriuretic peptide.mp. (36)125. BNP.mp. (4976)126. N-terminal-pro-natriuretic peptide.mp. (6)127. NTproBNP.mp. (99)128. NT-proBNP.mp. (1688)129. heart type fatty acid binding protein.mp. (196)130. heart-type fatty acid binding protein.mp. (196)131. H-FABP.mp. (312)132. (co-peptin or co?peptin or copeptin).mp. (116)133. adrenomedullin.mp. or Adrenomedullin/ (2412)134. ST-2.mp. (181)© Queen’s Printer and Controller of HMSO 2013. This work was produced by Goodacre et al. under the terms of a commissioning contract issued by the Secretary of Statefor Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journalsprovided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton SciencePark, Southampton SO16 7NS, UK.135
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Health Technology AssessmentVOLUME
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DOI: 10.3310/hta17010 Health Techno
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ContentsAppendix 5 Expected discoun
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BackgroundTABLE 1 Hospital admissio
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Background2. investigation of the c
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BackgroundComputed tomographic coro
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Research questionsiii. the diagnost
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Assessment of diagnostic and progno
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Page 128 and 129: Discussionspecificity were 62% (95%
Page 130 and 131: Discussionneed for revascularisatio
Page 132 and 133: Discussionchanges in sensitivity an
Page 134 and 135: Discussionuncertainty about these p
Page 136 and 137: Discussiontroponin assays have bett
Page 138 and 139: ConclusionsSuggested research prior
Page 156 and 157: Appendix 1135. interleukin 33.mp. (
Page 158 and 159: Appendix 147. 37 and 45 (529)48. li
Page 164 and 165: Appendix 313. Fernandez Portales JG
Page 166 and 167: Appendix 346. Luscher MS, Ravkilde
Page 168 and 169: Appendix 316. Rao SV, Ohman EM, Gra
Page 198 and 199: Appendix 9Clinical diagnosis of NST
Page 200 and 201: Appendix 9respectively. Exercise EC
Page 202 and 203: Appendix 93. Two reviewers will mak
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Appendix 9The methodology used in t
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Appendix 9ES (Information Resources
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Appendix 923. Westwood ME, Whiting
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