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References114. Newby LK, Storrow AB, Gibler WB, Garvey JL, Tucker JF, Kaplan AL, et al. Beside multimarkertesting for risk stratification in chest pain units: the Chest Pain Evaluation by Creatine Kinase-MB,Myoglobin, and Troponin I (CHECKMATE) study. Circulation 2001;103:1832–7.115. Ordonez-Llanos JS-B. Risk stratification of chest pain patients by point-of-care cardiac troponin Tand myoglobin measured in the emergency department. Clin Chim Acta 2006;365:93–7.116. Ponitz VB-A. Activated factor XII type A and B-type natriuretic peptide are complementary andincremental predictors of mortality in patients following admission with acute coronary syndrome.Blood Coagul Fibrinolysis 2009;20:652–60.117. Sonel A, Sasseen BM, Fineberg N, Bang N, Wilensky RL, Sonel A, et al. Prospective study correlatingfibrinopeptide A, troponin I, myoglobin, and myosin light chain levels with early and late ischemicevents in consecutive patients presenting to the emergency department with chest pain. Circulation2000;102:1107–13.118. Svensson L, Axelsson C, Nordlander R, Herlitz J, Svensson L, Axelsson C, et al. Prognostic valueof biochemical markers, 12-lead ECG and patient characteristics amongst patients calling for anambulance due to a suspected acute coronary syndrome. J Intern Med 2004;255:469–77.119. Szymanski FM, Grabowski M, Filipiak KJ, Karpinski G, Hrynkiewicz A, Stolarz P, et al. Prognosticimplications of myocardial necrosis triad markers’ concentration measured at admission in patientswith suspected acute coronary syndrome. Am J Emerg Med 2007;25:65–8.120. van Domburg RT, Cobbaert C, Kimman GJ, Zerback R, Simoons ML, van Domburg RT, et al. Longtermprognostic value of serial troponin T bedside tests in patients with acute coronary syndromes.Am J Cardiol 2000;86:623–7.121. Viswanathan K, Kilcullen N, Morrell C, Thistlethwaite SJ, Sivananthan MU, Hassan TB, et al.Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutivepatients with suspected acute coronary syndrome who are troponin-negative. J Am Coll Cardiol2010;55:2590–8.122. Yamashita T, Seino Y, Ogawa A, Ogata K, Fukushima M, Tanaka K, et al. N-terminal pro-BNP is anovel biomarker for integrated cardio-renal burden and early risk stratification in patients admittedfor cardiac emergency. J Cardiol 2010;55:377–83.123. Casciani E, Polettini E, Bertini L, Rotolo F, Truscelli G, Pittalis A, et al. 16-MDCT angiography coronaryartery in the emergency department for patients with acute coronary syndrome (NSTEMI-UA). ClinTer 2008;159:5–12.124. Coles DRW. Multislice computed tomography coronary angiography in patients admitted with asuspected acute coronary syndrome. Int J Cardiovasc Imag 2007;23:603–14.125. Ghersin E, Litmanovich D. 16-MDCT coronary angiography versus invasive coronary angiography inacute chest pain syndrome: a blinded prospective study. AJR Am J Roentgenol 2006;186:177–84.126. Henneman MM, Schuijf JD, Pundziute G, van Werkhoven JM, van der Wall EE, Jukema JW, etal. Noninvasive evaluation with multislice computed tomography in suspected acute coronarysyndrome: plaque morphology on multislice computed tomography versus coronary calcium score.J Am Coll Cardiol 2008;52:216–22.127. Minocha G, Khurana P, Minocha VA, Manocha S, Srivastava S, Agarwal P, et al. Diagnostic accuracyof multislice CT coronary angiography in patients presenting with non diagnostic chest pain. J AmColl Cardiol 2006;47:127A.128. Olivetti L, Mazza G, Volpi D, Costa F, Ferrari O, Pirelli S. Multislice CT in emergency roommanagement of patients with chest pain and medium-low probability of acute coronary syndrome.Radiol Med 2006;111:1054–63.128NIHR Journals Library
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Health Technology AssessmentVOLUME
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DOI: 10.3310/hta17010 Health Techno
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ContentsAppendix 5 Expected discoun
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BackgroundTABLE 1 Hospital admissio
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Background2. investigation of the c
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BackgroundComputed tomographic coro
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Research questionsiii. the diagnost
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Assessment of diagnostic and progno
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Page 128 and 129: Discussionspecificity were 62% (95%
Page 130 and 131: Discussionneed for revascularisatio
Page 132 and 133: Discussionchanges in sensitivity an
Page 134 and 135: Discussionuncertainty about these p
Page 136 and 137: Discussiontroponin assays have bett
Page 138 and 139: ConclusionsSuggested research prior
Page 154 and 155: Appendix 144. heart-type fatty acid
Page 156 and 157: Appendix 1135. interleukin 33.mp. (
Page 158 and 159: Appendix 147. 37 and 45 (529)48. li
Page 164 and 165: Appendix 313. Fernandez Portales JG
Page 166 and 167: Appendix 346. Luscher MS, Ravkilde
Page 168 and 169: Appendix 316. Rao SV, Ohman EM, Gra
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Appendix 9Clinical diagnosis of NST
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Appendix 9respectively. Exercise EC
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Appendix 93. Two reviewers will mak
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Appendix 9The methodology used in t
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Appendix 9ES (Information Resources
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Appendix 923. Westwood ME, Whiting
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