References83. Venge P, Johnston N, Lindahl B, James S. Normal plasma levels <strong>of</strong> cardiac troponin I measured bythe high-sensitivity cardiac troponin I access prototype assay <strong>and</strong> the impact on the diagnosis <strong>of</strong>myocardial ischemia. J Am Coll Cardiol 2009;54:1165–72.84. Wallace TW, Abdullah SM, Drazner MH, Das SR, Khera A, McGuire DK, et al. Prevalence <strong>and</strong>determinants <strong>of</strong> troponin T elevation in the general population. Circulation 2006;113:1958–65.85. Eggers KM, Dellborg M, Oldgren J, Swahn E, Venge P, Lindahl B, et al. Risk prediction inchest pain patients by biochemical markers including estimates <strong>of</strong> renal function. Int J Cardiol2008;128:207–13.86. Mockel MD. Development <strong>of</strong> an optimized multimarker strategy for early risk assessment <strong>of</strong> patientswith acute coronary syndromes. Clin Chim Acta 2008;393:103–9.87. Apple FS, Pearce LA, Chung A, Ler R, Murakami MM, Apple FS, et al. Multiple biomarker use fordetection <strong>of</strong> adverse events in patients presenting with symptoms suggestive <strong>of</strong> acute coronarysyndrome. Clin Chem 2007;53:874–81.88. Apple FS, Smith SW, Pearce LA, Schulz KM, Ler R, Murakami MAM, et al. Myeloperoxidase improvesrisk stratification in patients with ischemia <strong>and</strong> normal cardiac troponin I concentrations. Clin Chem2011;57:603–8.89. Bholasingh R, Cornel JH, Kamp O, Van Straalen JP, S<strong>and</strong>ers GT, Dijksman L, et al. The prognosticvalue <strong>of</strong> markers <strong>of</strong> inflammation in patients with troponin T-negative chest pain before dischargefrom the emergency department. Am J Med 2003;115:521–8.90. Blum AS. The prognostic value <strong>of</strong> high-sensitive C-reactive protein <strong>and</strong> cardiac troponin T in young<strong>and</strong> middle-aged patients with chest pain without ECG changes. Eur J Intern Med 2003;14:310–14.91. Brennan ML, Penn MS, Van LF, Nambi V, Shishehbor MH, Aviles RJ, et al. Prognostic value <strong>of</strong>myeloperoxidase in patients with chest pain. N Engl J Med 2003;349:1595–604.92. Brown AM, Sease KL, Robey JL, Sh<strong>of</strong>er FS, Holl<strong>and</strong>er JE. The impact <strong>of</strong> B-type natriuretic peptide inaddition to troponin I, creatine kinase-MB, <strong>and</strong> myoglobin on the risk stratification <strong>of</strong> emergencydepartment chest pain patients with potential acute coronary syndrome. Ann Emerg Med2007;49:153–63.93. Brugger-Andersen TP. B-type natriuretic peptide is a long-term predictor <strong>of</strong> all-cause mortality,whereas high-sensitive C-reactive protein predicts recurrent short-term troponin T positive cardiacevents in chest pain patients: A prognostic study. BMC Cardiovasc Disord 2008;8:34.94. Cameron SJ, Sokoll LJ, Laterza OF, Shah S, Green GB, Cameron SJ, et al. A multi-marker approachfor the prediction <strong>of</strong> adverse events in patients with acute coronary syndromes. Clin Chim Acta2007;376:168–73.95. Consuegra-Sanchez LB-M. Ischemia-modified albumin predicts short-term outcome <strong>and</strong> 1-yearmortality in patients attending the emergency department for acute ischemic chest pain. HeartVessels 2008;23:174–80.96. De Winter RJ, Koster RW, Schotveld JH, Sturk A, Van Straalen JP, S<strong>and</strong>ers GT, et al. Prognostic value<strong>of</strong> troponin T, myoglobin, <strong>and</strong> CK-MB mass in patients presenting with chest pain without acutemyocardial infarction. Heart 1996;75:235–9.97. Eggers KM, Kempf T, Allh<strong>of</strong>f T, Lindahl B, Wallentin L, Wollert KC, et al. Growth-differentiationfactor-15 for early risk stratification in patients with acute chest pain. Eur Heart J 2008;29:2327–35.98. Fromm R, Meyer D, Zimmerman J, Boudreaux A, Wun CC, Smalling R, et al. A double-blind,multicentered study comparing the accuracy <strong>of</strong> diagnostic markers to predict short- <strong>and</strong> long-termclinical events <strong>and</strong> their utility in patients presenting with chest pain. Clin Cardiol 2001;24:516–20.126NIHR Journals Library
DOI: 10.3310/hta17010 Health Technology Assessment 2013 Vol. 17 No. 199. Green GB, Skarbek-Borowski GW, Chan DW, Kelen GD, Green GB, Skarbek-Borowski GW, et al.Myoglobin for early risk stratification <strong>of</strong> emergency department patients with possible myocardialischemia. Acad Emerg Med 2000;7:625–36.100. Hillis GS, Taggart P, Hillis L, Zhao N, Dalsey WC, Mangione A, et al. Biochemical <strong>and</strong> clinicalpredictors <strong>of</strong> long-term outcome in patients with nonspecific chest pain <strong>and</strong> nondiagnosticelectrocardiograms. Am Heart J 200;145:88–94.101. Jaffery Z, Nowak R, Khoury N, Tokarski G, Lanfear DE, Jacobsen G, et al. Myoglobin <strong>and</strong> troponinI elevation predict 5-year mortality in patients with undifferentiated chest pain in the emergencydepartment. Am Heart J 2008;156:939–45.102. Jernberg T, Stridsberg M, Venge P, Lindahl B, Jernberg T, Stridsberg M, et al. N-terminal pro brainnatriuretic peptide on admission for early risk stratification <strong>of</strong> patients with chest pain <strong>and</strong> noST-segment elevation. J Am Coll Cardiol 2002;40:437–45.103. Kavsak PA, Wang XS, Henderson M, Ko DT, MacRae AR, Jaffe AS. PAPP-A as a marker <strong>of</strong> increasedlong-term risk in patients with chest pain. Clin Biochem 2009;42:1012–18.104. Kontos MC, Garg R, Anderson FP, Roberts CS, Ornato JP, Tatum JL, et al. Ability <strong>of</strong> myoglobin topredict mortality in patients admitted for exclusion <strong>of</strong> myocardial infarction. Am J Emerg Med2007;25:873–9.105. Laterza OF, Cameron SJ, Chappell D, Sokoll LJ, Green GB, Laterza OF, et al. Evaluation <strong>of</strong> pregnancyassociatedplasma protein A as a prognostic indicator in acute coronary syndrome patients. ClinChim Acta 2004;348:163–9.106. Lim J, Hawkins RC, Ng K, Chan SP, Cheng A, Ng KS, et al. A preliminary study <strong>of</strong> the utility <strong>of</strong>combined cardiac markers in the evaluation <strong>of</strong> patients presenting early with suspected acutecoronary syndrome. Ann Acad Med Singapore 2002;31:772–6.107. Lund J, Qin Q, Ilva T, Pettersson K, Voipio-Pulkki L, Porela P, et al. Circulating pregnancy-associatedplasma protein A predicts outcome in patients with acute coronary syndrome but no troponin Ielevation. Circulation 2003;108:1924–6.108. Manini AF, Ilgen J, Noble VE, Bamberg F, Koenig W, Bohan JS, et al. Derivation <strong>and</strong> validation<strong>of</strong> a sensitive IMA cutpoint to predict cardiac events in patients with chest pain. Emerg Med J2009;26:791–6.109. Markovic M, Ignjatovic S, Dajak M, Majkic-Singh N, Markovic M, Ignjatovic S, et al. Utility<strong>of</strong> placental growth factor for prediction <strong>of</strong> 30-day adverse event in emergency departmentpopulation with non-ST elevation acute coronary syndrome. Clin Lab 2010;56:215–22.110. Mathew T, Menown I, Smith B, Smye M, Nesbitt S, Young I, et al. Diagnosis <strong>and</strong> risk stratification <strong>of</strong>patients with anginal pain <strong>and</strong> non-diagnostic electrocardiograms. QJM 1999;92:565–71.111. McCann CJ, Glover BM, Menown IB, Moore MJ, McEneny J, Owens CG, et al. Prognostic value <strong>of</strong>a multimarker approach for patients presenting to hospital with acute chest pain. Am J Cardiol2009;103:22–8.112. McCord J, Nowak RM, Hudson MP, McCullough PA, Tomlanovich MC, Jacobsen G, et al. Theprognostic significance <strong>of</strong> serial myoglobin troponin I, <strong>and</strong> creatine kinase-MB measurements inpatients evaluated in the emergency department for acute coronary syndrome. Ann Emerg Med2003;42:343–50.113. Menown IB, Mathew TP, Gracey HM, Nesbitt GS, Murray P, Young IS, et al. Prediction <strong>of</strong> recurrentevents by D-Dimer <strong>and</strong> inflammatory markers in patients with normal cardiac troponin I (PREDICT).Study. Am Heart J 2003;145:986–92.© Queen’s Printer <strong>and</strong> Controller <strong>of</strong> HMSO 2013. This work was produced by Goodacre et al. under the terms <strong>of</strong> a commissioning contract issued by the Secretary <strong>of</strong> Statefor Health. This issue may be freely reproduced for the purposes <strong>of</strong> private research <strong>and</strong> study <strong>and</strong> extracts (or indeed, the full report) may be included in pr<strong>of</strong>essional journalsprovided that suitable acknowledgement is made <strong>and</strong> the reproduction is not associated with any form <strong>of</strong> advertising. Applications for commercial reproduction should beaddressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials <strong>and</strong> Studies Coordinating Centre, Alpha House, University <strong>of</strong> Southampton SciencePark, Southampton SO16 7NS, UK.127