Cornea - ARVO

ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - Corneayears). Female gender imparted a 1.7 fold increased risk of disease asdefined by the DEQ5 (95% CI 0.92-3.31, p-value 0.09). OSD basedon clinical signs was seen at a frequency of 91%; 69% of patients hadan MGD score >1. The use of a duodenal ulcer medication was foundto be a risk factor for OSD using both the DEQ-5 and OSDIdefinitions (OR 2.8 and 13.1, p values < 0.05). Patients with diabetesmellitus had less OSD by the DEQ5 definition compared to theircounterparts without diabetes (OR 0.12, 95% CI 0.02-0.98, p-value0.047).Conclusions: This is the first study to demonstrate the frequency ofsymptomatic and clinical OSD in a tertiary care ophthalmologycenter in Mexico. The frequency of OSD in our population rangedfrom 28% using a symptomatic definition to 91% using objectivemeasures.Commercial Relationships: Jaime D. Martinez, None; NallelyRamos-Betancourt, None; Anat Galor, None; Francisco Beltran,None; Jorge Ozorno-Zarate, None; Valeria Sánchez Huerta,None; Marco Antonio Torres Vera, None; Everardo Hernandez-Quintela, NoneProgram Number: 962 Poster Board Number: B0267Presentation Time: 1:00 PM - 2:45 PMBlink and Extended Blinks in a Dry Eye PopulationAshley M. LaFond, Patrick Johnston, John D. Rodriguez, Keith J.Lane, Endri Angjeli. Ora, Inc., Andover, MA.Purpose: The tracking of spontaneous blink activity has been shownto permit an investigator to gather important information on theclinical state of a dry eye subject. Previous research has shown thatthe majority of blinks are incomplete with zero lid contact durationtime. During a complete blink, lid duration contact time may varyfrom less than 10ms to 80ms. Eyelid closures of up to multipleseconds, which we refer to as "extended blinks", may also beobserved. Here we investigate the relative incidence of incompleteand extended blinks in a dry eye population.Methods: We consider a sample population of 11 non-MGD dry eyesubjects and a control group of 10 normal subjects. Blink informationwas obtained using video analysis of each subject viewing a 10minute nature documentary. Incomplete blinks were tracked bypercent of palpebral fissure closure as ¼, ½ and 3/4. Extended blinksof multiple seconds were classified per the cutpoints(sec) = (0, 0.1,1).Results: Total number of blinks observed for all subjects was 4990(1414 normal, 3756 dry eye). Of total blinks, 50.6% were incomplete(dry eye) versus 52% (normal). Dry eye subjects were over 10 timesmore likely than normals to exhibit blinks of one second duration orlonger (2.3% vs 0.2% of total respective blinks, p=0.023). Mean lidclosure duration for dry eye subjects was 7.074 (p