Cornea - ARVO

More documents

Recommendations

Info

ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - CorneaCommercial Relationships: Anna McKinney, None; William L.Miller, Contamac (F); Norman E. Leach, None; Cristina Polizzi,None; Eef van der Worp, Contamac (F); Jan P. Bergmanson,Contamac (F)Support: NIH/NEI grant T35EY00708 and Contamac USProgram Number: 5484 Poster Board Number: A0183Presentation Time: 8:30 AM - 10:15 AMDesigning Multifocal Contact Lenses using a Novel Through-Focus Image Quality Metric Highly Correlated with ClinicalVisual AcuityNishant Mohan, Amanda C. Kingston, Ian G. Cox. Bausch and Lomb,Rochester, NY.Purpose: The aim of this study was to validate the design process ofmultifocal contact lenses using a new through-focus image qualitymetric shown to correlate highly with clinical visual acuity.Methods: Individual eye models were created in commerciallyavailable optical design software (Zemax TM Bellevue, WA) andshown to correlate highly with baseline clinical through-focus visualacuity (R 2 = 0.85). For validation of predictability, 64 advancedpresbyopic eye models were used to predict through-focus imagequality of (5) multifocal contact lens designs. In Zemax TM , each ofthe (5) designs were inserted onto the anterior surface of the corneaand an over-refraction was done for each eye. Defocus wasminimized and the closest 0.25D lens was used to obtain peak imagequality at distance. Through-focus predicted logMAR wasdetermined for each eye model with each of the (5) multifocal lensesin place. To compare directly with clinical measurements of visualacuity, image quality with the contact lens on eye was subtractedfrom baseline values representing the individual eye's acuity withoutany corrective lens in place. This gives predicted normalizedlogMAR acuity. The same (7) object distances were used forcomputer modeling as in the actual clinical study. Normalized visualacuity for 24 mature presbyopes, tested monocularly, was measuredwith each of the (5) manufactured multifocals on-eye. Correlation ofclinical and predicted through-focus normalized acuity wasdetermined.Results: At all object distances, each multifocal had less than oneline difference on average between predicted and clinical normalizedlogMAR acuity. The Zemax TM models with predicted logMAR hadhigh correlation with through-focus visual acuity from the clinic (R 2between 0.90 and 0.97) for all multifocal lens designs.Conclusions: When multifocal contact lens designs were modeled onindividual computer eyes and normalized predicted logMAR wasused to determine how lenses would perform clinically, a highcorrelation was found between the computer database and averageclinical acuity results with all (5) multifocal contact lenses. Thisdesign process is highly effective in predicting on-eye performance.With this high level of predictability more design options can beexplored in the computer to optimize though-focus performancebefore a lens is manufactured and tested clinically.Commercial Relationships: Nishant Mohan, Bausch + Lomb (E);Amanda C. Kingston, Bausch & Lomb (E); Ian G. Cox, Bausch +Lomb (E)Program Number: 5485 Poster Board Number: A0184Presentation Time: 8:30 AM - 10:15 AMProsthetic Replacement of the Ocular Surface Ecosystem(PROSE) Treatment: A Partner Clinic ExperienceKira L. Segal 1 , Michelle N. Lee 2 , Kristin O. Chapman 2 , MarkRosenblatt 2 , Kimberly C. Sippel 2 , Christopher E. Starr 2 , JessicaCiralsky 2 . 1 Medicine, Memorial Sloan Kettering Cancer Center, NewYork, NY; 2 Ophthalmology, NewYork-Presbyterian, New York, NY.Purpose: PURPOSE: To evaluate demographics, clinical course, andoutcomes of patients who received the PROSE device at a partnerclinic.Methods: METHODS: Retrospective chart review of 37 consecutivepatients (66 eyes) fit with the PROSE device.Results: RESULTS: Indications for PROSE treatment includedectasia in 17 eyes (25.8%) and ocular surface disease in 49 eyes(74.2%). The average follow-up time was 4.76 months (2.4-9.35).Visual acuity improved with the PROSE device a statisticallysignificant amount (p=0.002). All patients had improved ocularsymptoms and decreased reliance on topical lubricants.Conclusions: CONCLUSIONS: PROSE is an effective treatmentoption for many patients with complex corneal diseases.Commercial Relationships: Kira L. Segal, None; Michelle N. Lee,None; Kristin O. Chapman, None; Mark Rosenblatt, None;Kimberly C. Sippel, None; Christopher E. Starr, None; JessicaCiralsky, NoneProgram Number: 5486 Poster Board Number: A0185Presentation Time: 8:30 AM - 10:15 AMEffect of Static and Non-Static in-vitro Techniques on LipidPenetration Into SiHy Contact LensesJean T. Jacob 1, 2 , Rebecca Frederick 1, 2 , Caitlin Tucker 1, 3 , LeaannLove 1, 4 . 1 Department of Ophthalmology, LSU Health SciencesCenter, New Orleans, LA; 2 Biomedical Engineering, TulaneUniversity, New Orleans, LA; 3 University of New Orleans, NewOrleans, LA; 4 Xavier University, New Orleans, LA.Purpose: We investigated the effect of replenishing the artificial tearfluid (ATF) over the study period on the lipid penetration profile intosilicone hydrogel lenses.Methods: We compared the lipid biofouling penetration profiles offive contact lens materials after 12 hours of exposure to static ATFdaily wear conditions and daily wear conditions where the ATF wasreplaced hourly using fluorescently-labeled phosphatidylcholine andcholesterol. Lipid penetration differences between the central 6 mmand the peripheral edges of the lenses were imaged with confocalmicroscopy.Results: The non-static method allowed for more adsorption andpenetration of both phosphatidylcholine and cholesterol into alllenses types tested (p=0.0001). There was approximately a 2-foldincrease in the amount of cholesterol found in all the lenses with thenon-static method as compared to the static. While there was also anincrease in the amount of PC within all lenses with the non-staticmethod compared to the static method is was not as significant as thecholesterol. The non-static method also showed more significantdifferences between the lipid penetration profiles for the lens typescompared to the static method. The non-static method showed moresurface penetration of PC in the periphery of the lens as compared tothe center for Acuvue Oasys, Biofinity and PureVision 2 than AirOptix and AirOptix Aqua which was not seen with the static method.However, the penetration profile for cholesterol did not changesignificantly between the non-static and the static methods for any ofthe lenses tested.Conclusions: The non-static method provided better differentialanalysis of lipid penetration into contact lens materials than the staticmethod. Specific differences based on lipid type and material surface©2013, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permissionto reproduce any abstract, contact the ARVO Office at arvo@arvo.org.
ARVO 2013 Annual Meeting Abstracts by Scientific Section/Group - Corneastructure were able to be identified that were not seen with the staticmethod. Future studies on contact lenses biofouling should use nonstaticmethodologies to more accurately mimic the in vivoenvironment.Commercial Relationships: Jean T. Jacob, 4,865,601 (P),5,282,851 (P); Rebecca Frederick, None; Caitlin Tucker, None;Leaann Love, NoneSupport: Unrestricted grant Research to Prevent BlindnessProgram Number: 5487 Poster Board Number: A0186Presentation Time: 8:30 AM - 10:15 AMVisual Performance and Optical Quality with New SiliconehydrogelSoft Contact Lenses for KeratoconusAsaki Suzaki 1 , Naoyuki Maeda 2 , Mutsumi Fuchihata 2 , Shizuka Koh 2 ,Kohji Nishida 2 , Takashi Fujikado 1 . 1 Applied Visual Science, OsakaUniversity Graduate School of Medicine, Suita, Japan;2 Ophthalmology, Osaka University Graduate School of Medicine,Suita, Japan.Purpose: To study the visual performances of a novel siliconehydrogelsoft contact lens (Si-SCL), which was designed to correct arefractive vertical asymmetry in keratoconic eyes.Methods: Fifty eyes of 37 subjects with mild keratoconus wererecruited for the study. Measurements included corneal anterioroptical coherence tomography (SS-1000, Tomey), wavefrontaberrometry (KR-1W, Topcon), subjective refraction, visual acuity(VA), visual clarity with visual analog scale (VAS). Study lenseswere made by molding method and were consisted of 6 types, inwhich asymmetrical power distribution (2D, 4D, 6D, 8D, 10D, 12D)was created to correct vertical irregular astigmatism. Based on thetopography and aberrometry data, the type of lenses was selected andfitted to the subjects. Evaluation of the on-eye performance of thelens was carried out, including wavefront aberrometry (4mm pupil,root mean square), over-refraction, VA, visual clarity with VAS.Results: Monocular visual performance with a Si-SCL improvedfrom -0.03±0.13 to -0.08±0.08 LogMAR in VA (p
Page 2 and 3:
ARVO 2013 Annual Meeting Abstracts
Page 4 and 5:
Page 6 and 7:
Page 8 and 9:
Page 10:
Page 13 and 14:
Page 16 and 17:
Page 18 and 19:
Page 20 and 21:
Page 22 and 23:
Page 24 and 25:
Page 26 and 27:
Page 28 and 29:
Page 30 and 31:
Page 32 and 33:
Page 34 and 35:
Page 36 and 37:
Page 38 and 39:
Page 40 and 41:
Page 42 and 43:
Page 44 and 45:
Page 46 and 47:
Page 48 and 49:
Page 50 and 51:
Page 52 and 53:
Page 54 and 55:
Page 56 and 57:
Page 58 and 59:
Page 60 and 61:
Page 62 and 63:
Page 64 and 65:
Page 66 and 67:
Page 68 and 69:
Page 70 and 71:
Page 72 and 73:
Page 74 and 75:
Page 76 and 77:
Page 78 and 79:
Page 80 and 81:
Page 82 and 83:
Page 84 and 85:
Page 86 and 87:
Page 88 and 89:
Page 90 and 91:
Page 92 and 93:
Page 94 and 95:
Page 96 and 97:
Page 98 and 99:
Page 100 and 101:
Page 102 and 103:
Page 104 and 105:
Page 106 and 107:
Page 108 and 109:
Page 110 and 111:
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
Page 118 and 119:
Page 120 and 121:
Page 122 and 123:
Page 124 and 125:
Page 126 and 127:
Page 128 and 129:
Page 130 and 131:
Page 132 and 133:
Page 134 and 135:
Page 136 and 137:
Page 138 and 139:
Page 140 and 141:
Page 142 and 143:
Page 144 and 145:
Page 146 and 147:
Page 148 and 149:
Page 150 and 151:
Page 152 and 153:
Page 154 and 155:
Page 156 and 157:
Page 158 and 159:
Page 160 and 161:
Page 162 and 163:
Page 164 and 165:
Page 166 and 167:
Page 168 and 169:
Page 170 and 171:
Page 172 and 173:
Page 174 and 175:
Page 176 and 177:
Page 178 and 179:
Page 180 and 181:
Page 182 and 183:
Page 184 and 185:
Page 186 and 187:
Page 188 and 189:
Page 190 and 191:
Page 192 and 193:
Page 194 and 195:
Page 196 and 197:
Page 198 and 199:
Page 200 and 201:
Page 202 and 203:
Page 204 and 205:
Page 206 and 207:
Page 208 and 209:
Page 210 and 211:
Page 212 and 213:
Page 214 and 215:
Page 216 and 217:
Page 218 and 219:
Page 220 and 221:
Page 222 and 223:
Page 224 and 225:
Page 226 and 227:
Page 228 and 229:
Page 230 and 231:
Page 232 and 233:
Page 234 and 235:
Page 236 and 237:
Page 238 and 239:
Page 240 and 241:
Page 242 and 243:
Page 244 and 245:
Page 246 and 247:
Page 248 and 249:
Page 250 and 251:
Page 252 and 253:
Page 254 and 255:
Page 256 and 257:
Page 258 and 259:
Page 260 and 261:
Page 262 and 263:
Page 264 and 265:
Page 266 and 267:
Page 268 and 269:
Page 270 and 271:
Page 272 and 273:
Page 274 and 275:
Page 276 and 277:
Page 278 and 279:
Page 280 and 281:
Page 282 and 283:
Page 284 and 285:
Page 286 and 287:
Page 288 and 289:
Page 290 and 291:
Page 292 and 293:
Page 294 and 295:
Page 296 and 297:
Page 298 and 299:
Page 300 and 301:
Page 302 and 303:
Page 304 and 305:
Page 306 and 307: ARVO 2013 Annual Meeting Abstracts
show all

Cornea - ARVO

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?